protein kinase C, alpha

 詳細情報を見る

同義遺伝子名

PKCA, PKC-A, protein kinase C, alpha, Protein kinase C alpha type, MGC129901, AAG6, MGC129900, PRKCA, PRKACA, PKC-alpha

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:79.40 小脳:50.40 脳幹:- 脳梁:29.20 松果体:- 末梢神経:122.70 脊柱:336.90 網膜:118.60 目:129.30 動脈:- 静脈:- リンパ節:80.90 末梢血:- 脾臓:132.30 胸腺:- 骨髄:59 脂肪:40.30 骨:38.40 皮膚:67.20
GeneChip 大脳:3.72 小脳:3.59 脳幹:3.88 脳梁:3.72 松果体:- 末梢神経:3.69 脊柱:3.77 網膜:- 目:- 動脈:3.55 静脈:3.97 リンパ節:3.51 末梢血:- 脾臓:3.41 胸腺:3.48 骨髄:3.83 脂肪:3.62 骨:- 皮膚:3.60
CAGE 大脳:4.33 小脳:- 脳幹:4.13 脳梁:4.51 松果体:3.00 末梢神経:- 脊柱:4.47 網膜:- 目:- 動脈:2.53 静脈:2.57 リンパ節:3.37 末梢血:- 脾臓:2.77 胸腺:1.65 骨髄:- 脂肪:2.35 骨:- 皮膚:-
RNA-seq 大脳:4.82 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:2.48 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:2.22 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:72.90 胎盤:14.60 前立腺:78.90 卵巣:74.50 精巣:17.30 心臓:51.10 骨格筋:- 食道:- 胃:42.50 腸:32.40 結腸:381.60     肝臓:158.30        肺:39.10    膀胱:- 腎臓:104 下垂体:- 甲状腺:- 副腎:152.40 膵臓:8.90 乳腺:102.20 唾液腺:-
GeneChip 子宮:3.49 胎盤:3.78 前立腺:3.42 卵巣:3.50 精巣:3.48 心臓:3.87 骨格筋:3.78 食道:3.51 胃:3.59 腸:3.69 結腸:3.80 肝臓:3.92 肺:3.59 膀胱:- 腎臓:3.73 下垂体:3.53 甲状腺:3.29 副腎:3.67 膵臓:4.16 乳腺:3.38 唾液腺:3.60
CAGE 子宮:3.49 胎盤:2.01 前立腺:3.93 卵巣:3.30 精巣:2.93 心臓:2.40 骨格筋:2.19 食道:2.51 胃:- 腸:3.88 結腸:3.90     肝臓:2.80    肺:2.82 膀胱:3.45 腎臓:3.22 下垂体:3.21 甲状腺:1.93 副腎:- 膵臓:2.76 乳腺:2.79 唾液腺:2.17
RNA-seq 子宮:- 胎盤:- 前立腺:3.36 卵巣:3.07 精巣:2.61 心臓:1.60 骨格筋:2.61 食道:- 胃:- 腸:- 結腸:3.04     肝臓:1.95        肺:2.00    膀胱:- 腎臓:2.98 下垂体:- 甲状腺:1.98 副腎:1.84 膵臓:- 乳腺:1.12 唾液腺:-

詳細情報

IDs

Refseq ID NM_002737
Gene ID 5578
Unigene ID Hs.531704
Probe set ID 206923_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000154229
GTEx ID ENSG00000154229

オーソログ対応遺伝子

マウス[2]  NM_011101
ラット[1]  NM_001105713

染色体

17q24.2  [64,298,944  -  64,801,114]

遺伝子ファミリー (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000008  C2 calcium-dependent membrane targeting
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR018029  C2 membrane targeting protein
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0007190  activation of adenylate cyclase activity
GO:0007202  activation of phospholipase C activity
GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0007155  cell adhesion
GO:0006874  cellular calcium ion homeostasis
GO:0071322  cellular response to carbohydrate stimulus
GO:0002062  chondrocyte differentiation
GO:0006112  energy reserve metabolic process
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0030198  extracellular matrix organization
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0010467  gene expression
GO:0000188  inactivation of MAPK activity
GO:0050930  induction of positive chemotaxis
GO:0045087  innate immune response
GO:0016071  mRNA metabolic process
GO:0007194  negative regulation of adenylate cyclase activity
GO:0008285  negative regulation of cell proliferation
GO:0034351  negative regulation of glial cell apoptosis
GO:0046325  negative regulation of glucose import
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0048011  nerve growth factor receptor signaling pathway
GO:0030593  neutrophil chemotaxis
GO:0007603  phototransduction, visible light
GO:0030168  platelet activation
GO:0045766  positive regulation of angiogenesis
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0045785  positive regulation of cell adhesion
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0050729  positive regulation of inflammatory response
GO:0031666  positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045651  positive regulation of macrophage differentiation
GO:0045931  positive regulation of mitotic cell cycle
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0050796  regulation of insulin secretion
GO:0006937  regulation of muscle contraction
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0022400  regulation of rhodopsin mediated signaling pathway
GO:0002026  regulation of the force of heart contraction
GO:0070555  response to interleukin-1
GO:0016056  rhodopsin mediated signaling pathway
GO:0016070  RNA metabolic process
GO:0007165  signal transduction
GO:0007268  synaptic transmission

Cellular Component

GO:0043025  cell soma
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0030425  dendrite
GO:0005783  endoplasmic reticulum
GO:0031966  mitochondrial membrane
GO:0005654  nucleoplasm
GO:0048471  perinuclear region of cytoplasm
GO:0001750  photoreceptor outer segment
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004698  calcium-dependent protein kinase C activity
GO:0019899  enzyme binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004697  protein kinase C activity
GO:0008270  zinc ion binding