mitogen-activated protein kinase 8

 詳細情報を見る

同義遺伝子名

JNK1, JNK21B1/2, c-Jun N-terminal kinase 1, PRKM8, JNK-46, JNK, mitogen-activated protein kinase 8, Mitogen-activated protein kinase 8, Stress-activated protein kinase JNK1, JNK1A2, SAPK1, MAPK8

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:84.10 小脳:25.20 脳幹:- 脳梁:58.30 松果体:- 末梢神経:30.70 脊柱:- 網膜:118.60 目:35.30 動脈:30 静脈:- リンパ節:40.40 末梢血:18.20 脾臓:18.90 胸腺:25.80 骨髄:19.70 脂肪:- 骨:25.60 皮膚:52.80
GeneChip 大脳:5.67 小脳:5.87 脳幹:5.75 脳梁:5.74 松果体:- 末梢神経:5.44 脊柱:5.60 網膜:- 目:- 動脈:5.37 静脈:5.60 リンパ節:5.30 末梢血:- 脾臓:5.38 胸腺:5.36 骨髄:5.69 脂肪:5.62 骨:- 皮膚:5.38
CAGE 大脳:3.96 小脳:- 脳幹:3.88 脳梁:3.52 松果体:3.64 末梢神経:- 脊柱:3.67 網膜:- 目:- 動脈:3.36 静脈:3.35 リンパ節:3.43 末梢血:- 脾臓:3.19 胸腺:3.74 骨髄:- 脂肪:3.23 骨:- 皮膚:-
RNA-seq 大脳:2.67 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.00 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.00 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:54.70 胎盤:21.90 前立腺:33.80 卵巣:- 精巣:38.90 心臓:12.80 骨格筋:- 食道:- 胃:21.20 腸:- 結腸:67.80     肝臓:21.10        肺:78.20    膀胱:- 腎臓:31.20 下垂体:- 甲状腺:- 副腎:- 膵臓:26.70 乳腺:120.80 唾液腺:-
GeneChip 子宮:5.40 胎盤:5.69 前立腺:5.13 卵巣:5.47 精巣:5.91 心臓:5.84 骨格筋:5.83 食道:5.65 胃:5.63 腸:5.57 結腸:5.89 肝臓:5.52 肺:5.35 膀胱:- 腎臓:5.63 下垂体:5.63 甲状腺:5.35 副腎:5.60 膵臓:6.10 乳腺:5.33 唾液腺:5.76
CAGE 子宮:3.45 胎盤:3.27 前立腺:3.28 卵巣:3.27 精巣:3.89 心臓:3.29 骨格筋:3.17 食道:3.04 胃:- 腸:3.75 結腸:3.56     肝臓:3.37    肺:3.39 膀胱:2.93 腎臓:3.34 下垂体:4.00 甲状腺:3.11 副腎:- 膵臓:3.16 乳腺:3.43 唾液腺:3.70
RNA-seq 子宮:- 胎盤:- 前立腺:0.50 卵巣:0.15 精巣:1.41 心臓:0.04 骨格筋:0.47 食道:- 胃:- 腸:- 結腸:1.30     肝臓:0.00        肺:0.00    膀胱:- 腎臓:0.00 下垂体:- 甲状腺:0.00 副腎:0.78 膵臓:- 乳腺:0.00 唾液腺:-

詳細情報

IDs

Refseq ID NM_002750
Gene ID 5599
Unigene ID Hs.138211
Probe set ID 210477_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000107643
GTEx ID ENSG00000107643

オーソログ対応遺伝子

マウス[2]  NM_016700
ラット[2]  NM_016700

染色体

10q11.22  [49,514,698  -  49,647,403]

遺伝子ファミリー (Interpro ID)

IPR008351  JNK MAP kinase
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0071260  cellular response to mechanical stimulus
GO:0045087  innate immune response
GO:0007254  JNK cascade
GO:0007258  JUN phosphorylation
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0032091  negative regulation of protein binding
GO:0048011  nerve growth factor receptor signaling pathway
GO:0001503  ossification
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0090045  positive regulation of deacetylase activity
GO:0010628  positive regulation of gene expression
GO:0031063  regulation of histone deacetylation
GO:0032880  regulation of protein localization
GO:0051090  regulation of transcription factor activity
GO:0046686  response to cadmium ion
GO:0006950  response to stress
GO:0009411  response to UV
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0005524  ATP binding
GO:0042826  histone deacetylase binding
GO:0035033  histone deacetylase regulator activity
GO:0004705  JUN kinase activity
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity