mitogen-activated protein kinase kinase 1

同義遺伝子名

MAP kinase kinase 1, mitogen-activated protein kinase kinase 1, MAPK/ERK kinase 1, ERK activator kinase 1, MAPKK1, MEK1, PRKMK1, MAPKK 1, MKK1, MAP2K1

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:39.10

小脳:12.60

脳幹:-

脳梁:58.30

松果体:148.30

末梢神経:61.30

脊柱:112.30

網膜:-

目:35.30

動脈:89.90

静脈:66.60

リンパ節:151.70

末梢血:72.90

脾臓:37.80

胸腺:51.50

骨髄:137.80

脂肪:-

骨:38.40

皮膚:72

GeneChip

大脳:8.93

小脳:8.94

脳幹:8.25

脳梁:7.72

松果体:-

末梢神経:8.58

脊柱:8.40

網膜:-

目:-

動脈:7.59

静脈:8.20

リンパ節:8.19

末梢血:-

脾臓:8.02

胸腺:7.96

骨髄:8.23

脂肪:8.49

骨:-

皮膚:7.66

CAGE

大脳:4.64

小脳:-

脳幹:3.69

脳梁:3.45

松果体:3.85

末梢神経:-

脊柱:4.27

網膜:-

目:-

動脈:4.24

静脈:3.76

リンパ節:3.91

末梢血:-

脾臓:3.87

胸腺:3.64

骨髄:-

脂肪:4.18

骨:-

皮膚:-

RNA-seq

大脳:5.53

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:4.79

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:4.16

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:109.40

胎盤:10.90

前立腺:67.60

卵巣:-

精巣:26

心臓:76.60

骨格筋:-

食道:-

胃:42.50

腸:32.40

結腸:76.30

肝臓:52.80

肺:73.30

膀胱:-

腎臓:31.20

下垂体:116

甲状腺:-

副腎:101.60

膵臓:44.50

乳腺:55.80

唾液腺:-

GeneChip

子宮:7.72

胎盤:7.18

前立腺:8.13

卵巣:7.72

精巣:7.19

心臓:7.96

骨格筋:9

食道:8.73

胃:7.73

腸:7.96

結腸:7.77

肝臓:8.53

肺:8.23

膀胱:-

腎臓:8.02

下垂体:7.83

甲状腺:7.67

副腎:7.73

膵臓:7.46

乳腺:7.81

唾液腺:7.78

CAGE

子宮:3.44

胎盤:3.28

前立腺:3.55

卵巣:3.59

精巣:2.96

心臓:4.14

骨格筋:4.54

食道:3.77

胃:-

腸:3.48

結腸:3.65

肝臓:4.12

肺:4.10

膀胱:3.88

腎臓:3.72

下垂体:3.82

甲状腺:3.44

副腎:-

膵臓:3.67

乳腺:4.46

唾液腺:3.27

RNA-seq

子宮:-

胎盤:-

前立腺:4.31

卵巣:4.02

精巣:4.00

心臓:3.89

骨格筋:4.11

食道:-

胃:-

腸:-

結腸:4.07

肝臓:4.03

肺:4.83

膀胱:-

腎臓:4.41

下垂体:-

甲状腺:4.05

副腎:4.03

膵臓:-

乳腺:5.05

唾液腺:-

IDs

Refseq ID	NM_002755
Gene ID	5604
Unigene ID	Hs.145442
Probe set ID	202670_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000169032
GTEx ID	ENSG00000169032

オーソログ対応遺伝子

マウス[1]	NM_008927
ラット [0]

染色体

15q22.31 [66,679,155 - 66,783,882]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0000186	activation of MAPKK activity
GO:0007411	axon guidance
GO:0007050	cell cycle arrest
GO:0048870	cell motility
GO:0008283	cell proliferation
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0048313	Golgi inheritance
GO:0045087	innate immune response
GO:0008286	insulin receptor signaling pathway
GO:0030216	keratinocyte differentiation
GO:0060711	labyrinthine layer development
GO:0000165	MAPKKK cascade
GO:0032402	melanosome transport
GO:0007067	mitosis
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0034111	negative regulation of homotypic cell-cell adhesion
GO:0048011	nerve growth factor receptor signaling pathway
GO:0060674	placenta blood vessel development
GO:0045597	positive regulation of cell differentiation
GO:0030335	positive regulation of cell migration
GO:0032320	positive regulation of Ras GTPase activity
GO:0046579	positive regulation of Ras protein signal transduction
GO:0032968	positive regulation of RNA elongation from RNA polymerase II promoter
GO:0051291	protein heterooligomerization
GO:0007265	Ras protein signal transduction
GO:0090170	regulation of Golgi inheritance
GO:0032872	regulation of stress-activated MAPK cascade
GO:0003056	regulation of vascular smooth muscle contraction
GO:0048678	response to axon injury
GO:0051384	response to glucocorticoid stimulus
GO:0006979	response to oxidative stress
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0051403	stress-activated MAPK cascade
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0047496	vesicle transport along microtubule

Cellular Component

GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0032839	dendrite cytoplasm
GO:0005769	early endosome
GO:0005925	focal adhesion
GO:0005794	Golgi apparatus
GO:0005770	late endosome
GO:0005739	mitochondrion
GO:0005634	nucleus
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0005816	spindle pole body

Molecular Function

GO:0005524	ATP binding
GO:0004708	MAP kinase kinase activity
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0043539	protein serine/threonine kinase activator activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0017016	Ras GTPase binding
GO:0004728	receptor signaling protein tyrosine phosphatase activity

mitogen-activated protein kinase kinase 1

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function