protein tyrosine phosphatase, non-receptor type 6

詳細情報を見る

同義遺伝子名

protein tyrosine phosphatase, non-receptor type 6, SH-PTP1, Hematopoietic cell protein-tyrosine phosphatase, Tyrosine-protein phosphatase non-receptor type 6, PTP1C, PTP-1C, HCPH, SHP1, SHP-1, PTPN6, SHP-1L, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, HPTP1C

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:10.70 小脳:- 脳幹:- 脳梁:29.20 松果体:148.30 末梢神経:- 脊柱:- 網膜:- 目:17.60 動脈:- 静脈:- リンパ節:273 末梢血:291.50 脾臓:1304.50 胸腺:399.40 骨髄:413.30 脂肪:40.30 骨:179.10 皮膚:81.60
GeneChip 大脳:4.99 小脳:4.75 脳幹:5.30 脳梁:5.46 松果体:- 末梢神経:5.26 脊柱:5.48 網膜:- 目:- 動脈:5.61 静脈:5.74 リンパ節:8.48 末梢血:- 脾臓:8.93 胸腺:8.07 骨髄:8.24 脂肪:6.23 骨:- 皮膚:6.30
CAGE 大脳:1.72 小脳:- 脳幹:2.23 脳梁:2.57 松果体:1.52 末梢神経:- 脊柱:2.13 網膜:- 目:- 動脈:2.22 静脈:4.54 リンパ節:4.77 末梢血:- 脾臓:4.58 胸腺:4.08 骨髄:- 脂肪:2.82 骨:- 皮膚:-
RNA-seq 大脳:0.04 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.53 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.18 骨:- 皮膚:-
EST 子宮:45.60 胎盤:54.60 前立腺:45.10 卵巣:- 精巣:- 心臓:25.50 骨格筋:- 食道:- 胃:42.50 腸:259.20 結腸:50.90     肝臓:42.20        肺:161.30    膀胱:251.20 腎臓:41.60 下垂体:- 甲状腺:327.50 副腎:50.80 膵臓:35.60 乳腺:83.60 唾液腺:-
GeneChip 子宮:5.68 胎盤:5.99 前立腺:6 卵巣:5.77 精巣:5.11 心臓:5.31 骨格筋:5.07 食道:6 胃:6.28 腸:6.25 結腸:6.45 肝臓:6.27 肺:7.69 膀胱:- 腎臓:5.87 下垂体:5.72 甲状腺:6.18 副腎:5.87 膵臓:6 乳腺:6.32 唾液腺:5.84
CAGE 子宮:2.15 胎盤:2.80 前立腺:2.51 卵巣:1.89 精巣:1.38 心臓:1.77 骨格筋:0.98 食道:2.85 胃:- 腸:3.01 結腸:3.07     肝臓:2.52    肺:3.87 膀胱:1.81 腎臓:2.60 下垂体:1.95 甲状腺:2.13 副腎:- 膵臓:2.76 乳腺:1.68 唾液腺:2.72
RNA-seq 子宮:- 胎盤:- 前立腺:0.05 卵巣:0.04 精巣:0.07 心臓:0.04 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:0.12     肝臓:0.00        肺:0.76    膀胱:- 腎臓:0.24 下垂体:- 甲状腺:0.32 副腎:1.09 膵臓:- 乳腺:0.05 唾液腺:-

IDs

Refseq ID NM_080549
Gene ID 5777
Unigene ID Hs.63489
Probe set ID 206687_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000111679
GTEx ID ENSG00000111679

オーソログ対応遺伝子

マウス[3]  NM_001077705, NM_013545
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1639416
1652101
1732748
1736296
7512963
7518460
7528577
7539038
7539106
7618087
7629131
7665165
7673163
7684496
7716523
7781604
7889566
8114715
8125298
8246974
8524272
8541543
8574854
8627166
8632004
8638162
8647855
8692915
8760799
8780698
8790380
8943344
8943354
9029147
9045636
9064344
9074930
9148918
9151699
9162089
9211920
9244303
9254654
9261115
9285411
9285412
9305905
9368621
9379041
9405464
9482905
9485206
9507021
9520455
9528781
9531263
9590210
9632636
9632768
9712903
9733788
9740800
9765283
9774441
9774457
9788431
9813145
9842885
9867848
9890995
9973385
10072516
10082557
10206955
10228003
10229828
10350061
10457220
10458769
10488096
10497187
10506221
10506573
10521452
10574931
10585470
10617656
10640770
10660565
10660620
10747947
10764762
10772872
10790433
10800945
10835420
10903717
10903736
10940933
11001933
11027300
11042209
11114375
11160222
11162587
11171044
11178971
11266449
11278955
11294838
11328818
11337495
11356834
11414741
11489943
11511520
11544253
11551923
11714803
11723252
11786908
11812650
11826756
11858824
11895767
11907066
11920268
11964172
11986327
11987243
12051764
12130517
12145285
12145687
12163025
12176037
12176909
12196526
12198247
12361947
12393607
12438221
12459556
12468540
12468645
12477932
12482860
12571228
12591278
12646642
12705885
12734331
12774026
12791978
12796776
12832410
12882840
12917349
14500659
14551136
14630083
14662855
14672952
14691303
14976049
15070900
15184070
15187115
15197735
15269224
15339845
15456853
15489334
15549731
15557341
15574429
15579525
15588985
15701718
15746253
15831474
15870198
16169070
16326706
16341674
16344560
16453023
16482509
16501054
17046078
17079228
17142110
17143285
17218319
17227821
17239936
17272397
17404032
17561098
17579069
18029348
18086677
18174230
18209728
18377662
18441283
18502033
18543080
18604210
18729074
18802077
18948549
18952289
19056867
19096001
19104650
19147543
19166311
19167335
19204726
19234487
19379557
19398961
19542910
19543515
19551406
19561639
19591923
19619438
19749791
19789387
19838216
19874234
19950550
20068065
20117097
20130595
20196786
20351292
20398180
20424160
20687222
20696858
20840866
21291405
21357539
21406173
21465528
21505184
21505186
21536801
21604205
21719561
21799016
21806449
21818116
21821701
21890473
21900501
21906983
21964525
22043923
22180308
22210881
22258937
22371396
22458809
22458980
22488585
22505724
22539788
22589543
22730659
22738830
22939629
22960265
23074279
23391724
23406209
23766558
23842094
23979523
24100145
24510345
24816145

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0050853  B cell receptor signaling pathway
GO:0007596  blood coagulation
GO:0030154  cell differentiation
GO:0008283  cell proliferation
GO:0019221  cytokine-mediated signaling pathway
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0050900  leukocyte migration
GO:0042267  natural killer cell mediated cytotoxicity
GO:0008285  negative regulation of cell proliferation
GO:0002924  negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043407  negative regulation of MAP kinase activity
GO:0050732  negative regulation of peptidyl-tyrosine phosphorylation
GO:0042130  negative regulation of T cell proliferation
GO:0050860  negative regulation of T cell receptor signaling pathway
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0008284  positive regulation of cell proliferation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0006470  protein amino acid dephosphorylation
GO:0045577  regulation of B cell differentiation
GO:0070372  regulation of ERK1 and ERK2 cascade
GO:0060334  regulation of interferon-gamma-mediated signaling pathway
GO:0060338  regulation of type I interferon-mediated signaling pathway
GO:0031295  T cell costimulation
GO:0060337  type I interferon-mediated signaling pathway

Cellular Component

GO:0042105  alpha-beta T cell receptor complex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0016020  membrane
GO:0005634  nucleus

Molecular Function

GO:0001784  phosphotyrosine binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity
GO:0042169  SH2 domain binding
GO:0017124  SH3 domain binding
GO:0005001  transmembrane receptor protein tyrosine phosphatase activity