B-cell CLL/lymphoma 2

詳細情報を見る

同義遺伝子名

BCL 2, Bcl-2, BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:28.40 小脳:12.60 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:112.30 網膜:118.60 目:5.90 動脈:30 静脈:- リンパ節:50.60 末梢血:54.70 脾臓:18.90 胸腺:38.70 骨髄:236.20 脂肪:121 骨:38.40 皮膚:86.40
GeneChip 大脳:5.32 小脳:5.23 脳幹:5.21 脳梁:5.43 松果体:- 末梢神経:5.25 脊柱:5.44 網膜:- 目:- 動脈:5.25 静脈:5.45 リンパ節:5.17 末梢血:- 脾臓:5.18 胸腺:5.14 骨髄:5.49 脂肪:5.41 骨:- 皮膚:5.04
CAGE 大脳:2.90 小脳:- 脳幹:3.15 脳梁:3.26 松果体:2.29 末梢神経:- 脊柱:3.43 網膜:- 目:- 動脈:3.30 静脈:3.98 リンパ節:3.66 末梢血:- 脾臓:3.80 胸腺:3.77 骨髄:- 脂肪:3.59 骨:- 皮膚:-
RNA-seq 大脳:2.56 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.77 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:3.62 骨:- 皮膚:-
EST 子宮:27.30 胎盤:167.60 前立腺:45.10 卵巣:447.20 精巣:30.30 心臓:51.10 骨格筋:20.10 食道:- 胃:233.70 腸:- 結腸:33.90     肝臓:21.10        肺:34.20    膀胱:- 腎臓:93.60 下垂体:- 甲状腺:163.70 副腎:- 膵臓:8.90 乳腺:204.40 唾液腺:-
GeneChip 子宮:5.18 胎盤:5.86 前立腺:4.90 卵巣:5.20 精巣:4.85 心臓:5.25 骨格筋:5.71 食道:5.08 胃:5 腸:5.29 結腸:5.15 肝臓:4.95 肺:4.97 膀胱:- 腎臓:5.16 下垂体:5.40 甲状腺:5.68 副腎:5.10 膵臓:5.64 乳腺:5.16 唾液腺:5.22
CAGE 子宮:3.81 胎盤:4.00 前立腺:3.13 卵巣:3.36 精巣:2.50 心臓:2.77 骨格筋:1.85 食道:2.61 胃:- 腸:2.79 結腸:3.14     肝臓:1.21    肺:2.73 膀胱:3.05 腎臓:2.78 下垂体:2.74 甲状腺:4.03 副腎:- 膵臓:1.21 乳腺:4.15 唾液腺:1.95
RNA-seq 子宮:- 胎盤:- 前立腺:2.94 卵巣:3.39 精巣:2.39 心臓:1.58 骨格筋:2.41 食道:- 胃:- 腸:- 結腸:3.18     肝臓:0.56        肺:1.90    膀胱:- 腎臓:2.48 下垂体:- 甲状腺:3.82 副腎:3.48 膵臓:- 乳腺:4.00 唾液腺:-

IDs

Refseq ID NM_000633
Gene ID 596
Unigene ID Hs.150749
Probe set ID 203684_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000171791
GTEx ID ENSG00000171791

オーソログ対応遺伝子

マウス[2]  NM_009741, NM_177410
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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24088574
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24448706
24491548
24503791
24516200
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24706857
24745187

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007015  actin filament organization
GO:0006915  apoptosis
GO:0070059  apoptosis in response to endoplasmic reticulum stress
GO:0031103  axon regeneration
GO:0007409  axonogenesis
GO:0001782  B cell homeostasis
GO:0002326  B cell lineage commitment
GO:0042100  B cell proliferation
GO:0050853  B cell receptor signaling pathway
GO:0001662  behavioral fear response
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0043375  CD8-positive, alpha-beta T cell lineage commitment
GO:0007569  cell aging
GO:0008219  cell death
GO:0016049  cell growth
GO:0016337  cell-cell adhesion
GO:0071310  cellular response to organic substance
GO:0021747  cochlear nucleus development
GO:0051607  defense response to virus
GO:0048589  developmental growth
GO:0048546  digestive tract morphogenesis
GO:0043583  ear development
GO:0032469  endoplasmic reticulum calcium ion homeostasis
GO:0007565  female pregnancy
GO:0048041  focal adhesion formation
GO:0000082  G1/S transition of mitotic cell cycle
GO:0022612  gland morphogenesis
GO:0032835  glomerulus development
GO:0031069  hair follicle morphogenesis
GO:0048873  homeostasis of number of cells within a tissue
GO:0006959  humoral immune response
GO:0008625  induction of apoptosis via death domain receptors
GO:0045087  innate immune response
GO:0002320  lymphoid progenitor cell differentiation
GO:0008584  male gonad development
GO:0006582  melanin metabolic process
GO:0030318  melanocyte differentiation
GO:0014031  mesenchymal cell development
GO:0001656  metanephros development
GO:0043066  negative regulation of apoptosis
GO:0010507  negative regulation of autophagy
GO:0010523  negative regulation of calcium ion transport into cytosol
GO:0030308  negative regulation of cell growth
GO:0030336  negative regulation of cell migration
GO:0032848  negative regulation of cellular pH reduction
GO:0051902  negative regulation of mitochondrial depolarization
GO:0045930  negative regulation of mitotic cell cycle
GO:0033033  negative regulation of myeloid cell apoptosis
GO:0043524  negative regulation of neuron apoptosis
GO:0030279  negative regulation of ossification
GO:0033689  negative regulation of osteoblast proliferation
GO:0046671  negative regulation of retinal cell programmed cell death
GO:0051402  neuron apoptosis
GO:0048599  oocyte development
GO:0035265  organ growth
GO:0001503  ossification
GO:0001541  ovarian follicle development
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0048753  pigment granule organization
GO:0030890  positive regulation of B cell proliferation
GO:0043085  positive regulation of catalytic activity
GO:0030307  positive regulation of cell growth
GO:0045636  positive regulation of melanocyte differentiation
GO:0040018  positive regulation of multicellular organism growth
GO:0014042  positive regulation of neuron maturation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0048743  positive regulation of skeletal muscle fiber development
GO:0014911  positive regulation of smooth muscle cell migration
GO:0009791  post-embryonic development
GO:0006470  protein amino acid dephosphorylation
GO:0000209  protein polyubiquitination
GO:0051924  regulation of calcium ion transport
GO:0001952  regulation of cell-matrix adhesion
GO:0010559  regulation of glycoprotein biosynthetic process
GO:0046902  regulation of mitochondrial membrane permeability
GO:0051881  regulation of mitochondrial membrane potential
GO:0006808  regulation of nitrogen utilization
GO:0043497  regulation of protein heterodimerization activity
GO:0043496  regulation of protein homodimerization activity
GO:0031647  regulation of protein stability
GO:0022898  regulation of transmembrane transporter activity
GO:0045069  regulation of viral genome replication
GO:0001836  release of cytochrome c from mitochondria
GO:0003014  renal system process
GO:0001101  response to acid
GO:0034097  response to cytokine stimulus
GO:0006974  response to DNA damage stimulus
GO:0042493  response to drug
GO:0009605  response to external stimulus
GO:0010332  response to gamma radiation
GO:0051384  response to glucocorticoid stimulus
GO:0042542  response to hydrogen peroxide
GO:0010039  response to iron ion
GO:0035094  response to nicotine
GO:0009314  response to radiation
GO:0009636  response to toxin
GO:0010224  response to UV-B
GO:0048536  spleen development
GO:0033077  T cell differentiation in the thymus
GO:0043029  T cell homeostasis
GO:0048538  thymus development

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0016020  membrane
GO:0005741  mitochondrial outer membrane
GO:0005739  mitochondrion
GO:0043209  myelin sheath
GO:0031965  nuclear membrane
GO:0005634  nucleus
GO:0046930  pore complex

Molecular Function

GO:0051434  BH3 domain binding
GO:0015267  channel activity
GO:0016248  channel inhibitor activity
GO:0042802  identical protein binding
GO:0002020  protease binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0051721  protein phosphatase 2A binding
GO:0043565  sequence-specific DNA binding
GO:0008134  transcription factor binding
GO:0031625  ubiquitin protein ligase binding