nucleotide-binding oligomerization domain containing 2

詳細情報を見る

同義遺伝子名

caspase recruitment domain family, member 15, Caspase recruitment domain-containing protein 15, ACUG, NOD2B, Protein Nod2, CARD15, NOD2, BLAU, PSORAS1, IBD1, Inflammatory bowel disease protein 1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:1.20 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:18.90 胸腺:- 骨髄:39.40 脂肪:- 骨:- 皮膚:4.80
GeneChip 大脳:3.67 小脳:3.69 脳幹:3.68 脳梁:3.59 松果体:- 末梢神経:3.78 脊柱:3.65 網膜:- 目:- 動脈:4.01 静脈:3.73 リンパ節:4.45 末梢血:- 脾臓:4.51 胸腺:3.73 骨髄:5.11 脂肪:4.18 骨:- 皮膚:5.65
CAGE 大脳:0.22 小脳:- 脳幹:0.44 脳梁:0.29 松果体:0.26 末梢神経:- 脊柱:0.74 網膜:- 目:- 動脈:1.10 静脈:0.70 リンパ節:1.47 末梢血:- 脾臓:1.06 胸腺:0.28 骨髄:- 脂肪:0.78 骨:- 皮膚:-
RNA-seq 大脳:0.20 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.57 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.27 骨:- 皮膚:-
EST 子宮:- 胎盤:7.30 前立腺:- 卵巣:- 精巣:- 心臓:12.80 骨格筋:- 食道:- 胃:- 腸:- 結腸:8.50     肝臓:-        肺:4.90    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:4.07 胎盤:3.87 前立腺:3.74 卵巣:3.79 精巣:3.65 心臓:3.76 骨格筋:3.75 食道:5.59 胃:3.89 腸:4.09 結腸:3.95 肝臓:3.65 肺:4.47 膀胱:- 腎臓:3.62 下垂体:3.54 甲状腺:3.66 副腎:3.77 膵臓:3.78 乳腺:4.18 唾液腺:4.52
CAGE 子宮:0.71 胎盤:0.81 前立腺:0.62 卵巣:0.47 精巣:0.38 心臓:0.78 骨格筋:0.24 食道:1.85 胃:- 腸:0.07 結腸:0.18     肝臓:0.46    肺:1.54 膀胱:1.02 腎臓:0.27 下垂体:0.19 甲状腺:0.23 副腎:- 膵臓:0 乳腺:0 唾液腺:1.00
RNA-seq 子宮:- 胎盤:- 前立腺:0.28 卵巣:0.57 精巣:0.39 心臓:0.16 骨格筋:0.36 食道:- 胃:- 腸:- 結腸:0.11     肝臓:0.10        肺:1.67    膀胱:- 腎臓:0.27 下垂体:- 甲状腺:0.22 副腎:0.68 膵臓:- 乳腺:0.18 唾液腺:-

IDs

Refseq ID NM_022162
Gene ID 64127
Unigene ID Hs.592072
Probe set ID 220066_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000167207
GTEx ID ENSG00000167207

オーソログ対応遺伝子

マウス[1]  NM_145857
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

7809109
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0071224  cellular response to peptidoglycan
GO:0002367  cytokine production during immune response
GO:0006952  defense response
GO:0042742  defense response to bacterium
GO:0050830  defense response to Gram-positive bacterium
GO:0016045  detection of bacterium
GO:0009595  detection of biotic stimulus
GO:0032498  detection of muramyl dipeptide
GO:0002381  immunoglobulin production during immune response
GO:0045087  innate immune response
GO:0002227  innate immune response in mucosa
GO:0007254  JNK cascade
GO:0002282  microglial cell activation during immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0044130  negative regulation of growth of symbiont in host
GO:0002862  negative regulation of inflammatory response to antigenic stimulus
GO:0032689  negative regulation of interferon-gamma production
GO:0032695  negative regulation of interleukin-12 production
GO:0032701  negative regulation of interleukin-18 production
GO:0032703  negative regulation of interleukin-2 production
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0002710  negative regulation of T cell mediated immunity
GO:0034136  negative regulation of toll-like receptor 2 signaling pathway
GO:0032720  negative regulation of tumor necrosis factor production
GO:0070431  nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0052033  pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
GO:0050871  positive regulation of B cell activation
GO:0006965  positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0002606  positive regulation of dendritic cell antigen processing and presentation
GO:0002732  positive regulation of dendritic cell cytokine production
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046645  positive regulation of gamma-delta T cell activation
GO:0002925  positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032731  positive regulation of interleukin-1 beta production
GO:0050718  positive regulation of interleukin-1 beta secretion
GO:0032733  positive regulation of interleukin-10 production
GO:0032735  positive regulation of interleukin-12 production
GO:0032740  positive regulation of interleukin-17 production
GO:0032755  positive regulation of interleukin-6 production
GO:0046330  positive regulation of JNK cascade
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0045747  positive regulation of Notch signaling pathway
GO:0051353  positive regulation of oxidoreductase activity
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766  positive regulation of phagocytosis
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0060585  positive regulation of prostaglandin-endoperoxidase synthase activity
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0002830  positive regulation of T-helper 2 type immune response
GO:0032760  positive regulation of tumor necrosis factor production
GO:0051259  protein oligomerization
GO:0050727  regulation of inflammatory response
GO:0090022  regulation of neutrophil chemotaxis
GO:0043330  response to exogenous dsRNA
GO:0032496  response to lipopolysaccharide
GO:0032495  response to muramyl dipeptide
GO:0007584  response to nutrient
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0008180  signalosome
GO:0031982  vesicle

Molecular Function

GO:0005524  ATP binding
GO:0050700  CARD domain binding
GO:0019899  enzyme binding
GO:0032500  muramyl dipeptide binding
GO:0042834  peptidoglycan binding
GO:0005515  protein binding
GO:0019901  protein kinase binding