synuclein, alpha (non A4 component of amyloid precursor)

詳細情報を見る

同義遺伝子名

MGC110988, SNCA, Non-A4 component of amyloid precursor, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:3.60 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:61.30 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:4.80
GeneChip 大脳:8.81 小脳:9.30 脳幹:9.53 脳梁:8.32 松果体:- 末梢神経:8.73 脊柱:8.18 網膜:- 目:- 動脈:5.77 静脈:6.16 リンパ節:5.23 末梢血:- 脾臓:5.74 胸腺:5 骨髄:10.77 脂肪:5.83 骨:- 皮膚:6.36
CAGE 大脳:4.70 小脳:- 脳幹:4.65 脳梁:3.82 松果体:3.22 末梢神経:- 脊柱:4.08 網膜:- 目:- 動脈:2.74 静脈:1.65 リンパ節:1.43 末梢血:- 脾臓:1.69 胸腺:1.12 骨髄:- 脂肪:1.90 骨:- 皮膚:-
RNA-seq 大脳:5.69 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.75 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.64 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:6.54 胎盤:7.94 前立腺:6.57 卵巣:6.31 精巣:4.73 心臓:5.84 骨格筋:4.81 食道:5.99 胃:5.20 腸:5.83 結腸:6.71 肝臓:4.72 肺:5.72 膀胱:- 腎臓:5.11 下垂体:6.85 甲状腺:6.06 副腎:4.83 膵臓:5.24 乳腺:5.69 唾液腺:5.88
CAGE 子宮:2.92 胎盤:3.39 前立腺:1.81 卵巣:2.72 精巣:1.39 心臓:2.39 骨格筋:0.52 食道:2.43 胃:- 腸:1.46 結腸:1.80     肝臓:0.78    肺:2.49 膀胱:2.58 腎臓:1.51 下垂体:3.25 甲状腺:1.96 副腎:- 膵臓:1.21 乳腺:2.11 唾液腺:1.82
RNA-seq 子宮:- 胎盤:- 前立腺:1.68 卵巣:2.46 精巣:2.10 心臓:0.78 骨格筋:0.05 食道:- 胃:- 腸:- 結腸:3.26     肝臓:0.05        肺:3.74    膀胱:- 腎臓:1.51 下垂体:- 甲状腺:1.45 副腎:1.52 膵臓:- 乳腺:1.49 唾液腺:-

IDs

Refseq ID NM_000345
Gene ID 6622
Unigene ID Hs.21374
Probe set ID 204466_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000145335
GTEx ID ENSG00000145335

オーソログ対応遺伝子

マウス[4]  NM_001042451, NM_009221
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0008344  adult locomotory behavior
GO:0007568  aging
GO:0048148  behavioral response to cocaine
GO:0055074  calcium ion homeostasis
GO:0071280  cellular response to copper ion
GO:0034599  cellular response to oxidative stress
GO:0042416  dopamine biosynthetic process
GO:0051583  dopamine uptake
GO:0006631  fatty acid metabolic process
GO:0043206  fibril organization
GO:0060291  long-term synaptic potentiation
GO:0001774  microglial cell activation
GO:0042775  mitochondrial ATP synthesis coupled electron transport
GO:0007006  mitochondrial membrane organization
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0045963  negative regulation of dopamine metabolic process
GO:0051585  negative regulation of dopamine uptake
GO:0045920  negative regulation of exocytosis
GO:0035067  negative regulation of histone acetylation
GO:0031115  negative regulation of microtubule polymerization
GO:0032769  negative regulation of monooxygenase activity
GO:0043524  negative regulation of neuron apoptosis
GO:0051622  negative regulation of norepinephrine uptake
GO:0010642  negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0051612  negative regulation of serotonin uptake
GO:0070495  negative regulation of thrombin receptor signaling pathway
GO:0032410  negative regulation of transporter activity
GO:0006638  neutral lipid metabolic process
GO:0055114  oxidation reduction
GO:0006644  phospholipid metabolic process
GO:0045807  positive regulation of endocytosis
GO:0060732  positive regulation of inositol phosphate biosynthetic process
GO:0001956  positive regulation of neurotransmitter secretion
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0001921  positive regulation of receptor recycling
GO:0051281  positive regulation of release of sequestered calcium ion into cytosol
GO:0031648  protein destabilization
GO:0031623  receptor internalization
GO:0050812  regulation of acyl-CoA biosynthetic process
GO:0014059  regulation of dopamine secretion
GO:0060079  regulation of excitatory postsynaptic membrane potential
GO:0014048  regulation of glutamate secretion
GO:0040012  regulation of locomotion
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0043030  regulation of macrophage activation
GO:0010517  regulation of phospholipase activity
GO:0042493  response to drug
GO:0034341  response to interferon-gamma
GO:0070555  response to interleukin-1
GO:0010040  response to iron(II) ion
GO:0032496  response to lipopolysaccharide
GO:0032026  response to magnesium ion
GO:0050808  synapse organization
GO:0048488  synaptic vesicle endocytosis

Cellular Component

GO:0015629  actin cytoskeleton
GO:0030424  axon
GO:0005938  cell cortex
GO:0030054  cell junction
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005576  extracellular region
GO:0043205  fibril
GO:0005794  Golgi apparatus
GO:0030426  growth cone
GO:0016234  inclusion body
GO:0005739  mitochondrion
GO:0005640  nuclear outer membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0031092  platelet alpha granule membrane
GO:0005840  ribosome
GO:0005791  rough endoplasmic reticulum
GO:0008021  synaptic vesicle
GO:0043195  terminal button

Molecular Function

GO:0043014  alpha-tubulin binding
GO:0048487  beta-tubulin binding
GO:0005509  calcium ion binding
GO:0043027  caspase inhibitor activity
GO:0005507  copper ion binding
GO:0045502  dynein binding
GO:0005504  fatty acid binding
GO:0008198  ferrous iron binding
GO:0042393  histone binding
GO:0030544  Hsp70 protein binding
GO:0042802  identical protein binding
GO:0019894  kinesin binding
GO:0000287  magnesium ion binding
GO:0008017  microtubule binding
GO:0016491  oxidoreductase activity
GO:0043274  phospholipase binding
GO:0060961  phospholipase D inhibitor activity
GO:0005543  phospholipid binding
GO:0051219  phosphoprotein binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0047485  protein N-terminus binding
GO:0048156  tau protein binding
GO:0008270  zinc ion binding