transcription factor 7-like 2 (T-cell specific, HMG-box)

詳細情報を見る

同義遺伝子名

Transcription factor 7-like 2, T-cell-specific transcription factor 4, TCF4, hTCF-4, TCF7L2, TCF-4, HMG box transcription factor 4

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:2.40 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:17.60 動脈:- 静脈:- リンパ節:10.10 末梢血:18.20 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:12.80 皮膚:-
GeneChip 大脳:5.64 小脳:4.33 脳幹:4.99 脳梁:5.15 松果体:- 末梢神経:5.47 脊柱:5.18 網膜:- 目:- 動脈:5.87 静脈:5.72 リンパ節:4.76 末梢血:- 脾臓:5.45 胸腺:4.90 骨髄:4.16 脂肪:6.45 骨:- 皮膚:5.92
CAGE 大脳:3.86 小脳:- 脳幹:3.35 脳梁:4.30 松果体:4.42 末梢神経:- 脊柱:4.34 網膜:- 目:- 動脈:5.09 静脈:3.71 リンパ節:3.89 末梢血:- 脾臓:4.87 胸腺:3.34 骨髄:- 脂肪:4.86 骨:- 皮膚:-
RNA-seq 大脳:0.10 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.85 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:37.30 精巣:- 心臓:25.50 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:19.60    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:6.77 胎盤:6.07 前立腺:6.09 卵巣:6.96 精巣:5.28 心臓:5.44 骨格筋:4.95 食道:5.21 胃:6.08 腸:5.70 結腸:6.55 肝臓:5.69 肺:5.87 膀胱:- 腎臓:5.55 下垂体:5.01 甲状腺:5.80 副腎:5.33 膵臓:4.51 乳腺:6.59 唾液腺:5.46
CAGE 子宮:4.93 胎盤:4.67 前立腺:4.30 卵巣:4.51 精巣:4.04 心臓:4.13 骨格筋:4.08 食道:4.12 胃:- 腸:5.22 結腸:5.19     肝臓:4.53    肺:4.79 膀胱:4.62 腎臓:3.81 下垂体:4.62 甲状腺:4.07 副腎:- 膵臓:4.14 乳腺:5.41 唾液腺:4.08
RNA-seq 子宮:- 胎盤:- 前立腺:0.74 卵巣:0.47 精巣:0.01 心臓:0.00 骨格筋:0 食道:- 胃:- 腸:- 結腸:0.10     肝臓:1.41        肺:0.01    膀胱:- 腎臓:0.74 下垂体:- 甲状腺:1.45 副腎:0.05 膵臓:- 乳腺:1.43 唾液腺:-

IDs

Refseq ID NM_001146274
Gene ID 6934
Unigene ID Hs.593995
Probe set ID 216511_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000148737
GTEx ID ENSG00000148737

オーソログ対応遺伝子

マウス[32]  NM_001142918, NM_001142919, NM_001142920, NM_001142921, NM_001142922, NM_001142923, NM_001142924, NM_009333
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0001568  blood vessel development
GO:0030282  bone mineralization
GO:0007420  brain development
GO:0007050  cell cycle arrest
GO:0008283  cell proliferation
GO:0048557  embryonic digestive tract morphogenesis
GO:0030538  embryonic genitalia morphogenesis
GO:0048619  embryonic hindgut morphogenesis
GO:0060325  face morphogenesis
GO:0045444  fat cell differentiation
GO:0048699  generation of neurons
GO:0042593  glucose homeostasis
GO:0043570  maintenance of DNA repeat elements
GO:0048625  myoblast cell fate commitment
GO:0030514  negative regulation of BMP signaling pathway
GO:0045599  negative regulation of fat cell differentiation
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0046621  negative regulation of organ growth
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0021915  neural tube development
GO:0022008  neurogenesis
GO:0042475  odontogenesis of dentine-containing tooth
GO:0014003  oligodendrocyte development
GO:0031016  pancreas development
GO:0021983  pituitary gland development
GO:0043065  positive regulation of apoptosis
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010909  positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0032024  positive regulation of insulin secretion
GO:0032092  positive regulation of protein binding
GO:0046827  positive regulation of protein export from nucleus
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0032350  regulation of hormone metabolic process
GO:0031641  regulation of myelination
GO:0048713  regulation of oligodendrocyte differentiation
GO:0048641  regulation of skeletal muscle tissue development
GO:0048660  regulation of smooth muscle cell proliferation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0009749  response to glucose stimulus
GO:0032252  secretory granule localization
GO:0043588  skin development
GO:0035019  somatic stem cell maintenance
GO:0006351  transcription, DNA-dependent
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0070369  beta-catenin-TCF7L2 complex
GO:0000790  nuclear chromatin
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0016605  PML body
GO:0032993  protein-DNA complex
GO:0005667  transcription factor complex

Molecular Function

GO:0070016  armadillo repeat domain binding
GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0044212  DNA regulatory region binding
GO:0045295  gamma-catenin binding
GO:0035257  nuclear hormone receptor binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding