caspase 8, apoptosis-related cysteine peptidase

 詳細情報を見る

同義遺伝子名

Apoptotic protease Mch-5, FADD-like ICE, CASP8, MCH5, MGC78473, MORT1-associated CED-3 homolog, MACH, CASP-8, caspase 8, apoptosis-related cysteine peptidase, ICE-like apoptotic protease 5, Caspase-8 precursor, FLICE, Apoptotic cysteine protease, FADD-homologous ICE/CED-3-like protease, CAP4

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:3.64 小脳:3.58 脳幹:3.72 脳梁:4.01 松果体:- 末梢神経:3.99 脊柱:3.89 網膜:- 目:- 動脈:4.51 静脈:4.40 リンパ節:6.96 末梢血:- 脾臓:7.61 胸腺:7.54 骨髄:6.34 脂肪:5.65 骨:- 皮膚:5.41
CAGE 大脳:1.28 小脳:- 脳幹:1.98 脳梁:2.17 松果体:1.65 末梢神経:- 脊柱:2.37 網膜:- 目:- 動脈:2.56 静脈:3.68 リンパ節:4.17 末梢血:- 脾臓:4.23 胸腺:4.24 骨髄:- 脂肪:3.31 骨:- 皮膚:-
RNA-seq 大脳:0.27 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:3.44 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:1.12 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:5.34 胎盤:5.77 前立腺:5.12 卵巣:5.56 精巣:3.62 心臓:4.56 骨格筋:3.75 食道:5.60 胃:5.61 腸:5.64 結腸:5.83 肝臓:5.52 肺:6.09 膀胱:- 腎臓:5.29 下垂体:4.21 甲状腺:4.62 副腎:5.12 膵臓:4.24 乳腺:5.65 唾液腺:4.41
CAGE 子宮:2.93 胎盤:3.09 前立腺:3.02 卵巣:2.81 精巣:2.14 心臓:2.02 骨格筋:1.79 食道:3.15 胃:- 腸:4.15 結腸:3.29     肝臓:3.20    肺:3.44 膀胱:2.95 腎臓:3.43 下垂体:2.58 甲状腺:2.29 副腎:- 膵臓:2.41 乳腺:3.06 唾液腺:2.69
RNA-seq 子宮:- 胎盤:- 前立腺:1.87 卵巣:2.26 精巣:1.44 心臓:0.78 骨格筋:0.18 食道:- 胃:- 腸:- 結腸:0.96     肝臓:1.58        肺:1.41    膀胱:- 腎臓:2.23 下垂体:- 甲状腺:0.52 副腎:2.84 膵臓:- 乳腺:1.22 唾液腺:-

詳細情報

IDs

Refseq ID NM_033356
Gene ID 841
Unigene ID Hs.599762
Probe set ID 213373_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000064012
GTEx ID ENSG00000064012

オーソログ対応遺伝子

マウス[2]  NM_001080126, NM_009812
ラット[1]  NM_022277, NM_009812

染色体

2q33.1  [202,098,166  -  202,152,434]
LRG_34  [4,986  -  59,254]

遺伝子ファミリー (Interpro ID)

IPR001875  Death effector
IPR011029  DEATH-like
IPR011600  Peptidase C14, caspase catalytic
IPR015917  Peptidase C14, caspase precursor p45, core

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0006921  cell structure disassembly during apoptosis
GO:0071260  cellular response to mechanical stimulus
GO:0007507  heart development
GO:0045087  innate immune response
GO:0030225  macrophage differentiation
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0043124  negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0001841  neural tube formation
GO:0070423  nucleotide-binding oligomerization domain containing signaling pathway
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045651  positive regulation of macrophage differentiation
GO:0045862  positive regulation of proteolysis
GO:0051291  protein heterooligomerization
GO:0006508  proteolysis
GO:0051603  proteolysis involved in cellular protein catabolic process
GO:0046677  response to antibiotic
GO:0032025  response to cobalt ion
GO:0009409  response to cold
GO:0032355  response to estradiol stimulus
GO:0045471  response to ethanol
GO:0032496  response to lipopolysaccharide
GO:0034612  response to tumor necrosis factor
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0019048  virus-host interaction

Cellular Component

GO:0031265  CD95 death-inducing signaling complex
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0031264  death-inducing signaling complex
GO:0045121  membrane raft
GO:0005741  mitochondrial outer membrane
GO:0005739  mitochondrion
GO:0043005  neuron projection
GO:0030690  Noc1p-Noc2p complex
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0004197  cysteine-type endopeptidase activity
GO:0008234  cysteine-type peptidase activity
GO:0042802  identical protein binding
GO:0002020  protease binding
GO:0005515  protein binding
GO:0005164  tumor necrosis factor receptor binding