receptor (TNFRSF)-interacting serine-threonine kinase 1

詳細情報を見る

同義遺伝子名

Receptor-interacting protein, Cell death protein RIP, RIPK1, Serine/threonine-protein kinase RIP, FLJ39204

正常組織・臓器 40分類
細胞株・初代培養細胞・成体組織・胎児組織 (FANTOM5 CAGE)

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:34.40

小脳:88.20

脳幹:-

脳梁:29.20

松果体:-

末梢神経:-

脊柱:-

網膜:118.60

目:76.40

動脈:89.90

静脈:-

リンパ節:80.90

末梢血:-

脾臓:18.90

胸腺:25.80

骨髄:59

脂肪:-

骨:25.60

皮膚:14.40

GeneChip

大脳:5.02

小脳:5.22

脳幹:5.06

脳梁:5.08

松果体:-

末梢神経:5.32

脊柱:5.32

網膜:-

目:-

動脈:5.63

静脈:5.52

リンパ節:5.40

末梢血:-

脾臓:5.64

胸腺:5.85

骨髄:5.86

脂肪:5.92

骨:-

皮膚:6.22

CAGE

大脳:2.20

小脳:-

脳幹:2.42

脳梁:2.52

松果体:2.65

末梢神経:-

脊柱:2.60

網膜:-

目:-

動脈:3.21

静脈:3.06

リンパ節:3.19

末梢血:-

脾臓:3.06

胸腺:2.93

骨髄:-

脂肪:3.43

骨:-

皮膚:-

RNA-seq

大脳:2.28

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:3.07

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:3.48

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:18.20

胎盤:65.60

前立腺:112.60

卵巣:149.10

精巣:26

心臓:-

骨格筋:-

食道:-

胃:21.20

腸:97.20

結腸:59.40

肝臓:10.60

肺:44

膀胱:251.20

腎臓:31.20

下垂体:-

甲状腺:-

副腎:-

膵臓:53.30

乳腺:37.20

唾液腺:-

GeneChip

子宮:5.81

胎盤:6.24

前立腺:6.01

卵巣:5.65

精巣:4.91

心臓:5.31

骨格筋:5.26

食道:5.63

胃:5.89

腸:5.53

結腸:5.82

肝臓:5.43

肺:5.97

膀胱:-

腎臓:5.33

下垂体:5.43

甲状腺:5.42

副腎:4.99

膵臓:5.44

乳腺:5.81

唾液腺:5.34

CAGE

子宮:3.10

胎盤:3.29

前立腺:3.16

卵巣:2.83

精巣:2.55

心臓:3.06

骨格筋:2.67

食道:2.82

胃:-

腸:3.37

結腸:3.00

肝臓:3.61

肺:3.05

膀胱:2.82

腎臓:3.03

下垂体:3.20

甲状腺:3.06

副腎:-

膵臓:3.10

乳腺:3.58

唾液腺:2.93

RNA-seq

子宮:-

胎盤:-

前立腺:3.27

卵巣:3.36

精巣:2.83

心臓:2.06

骨格筋:2.19

食道:-

胃:-

腸:-

結腸:2.72

肝臓:3.29

肺:2.37

膀胱:-

腎臓:3.44

下垂体:-

甲状腺:3.38

副腎:4.02

膵臓:-

乳腺:3.42

唾液腺:-

IDs

Refseq ID	NM_003804
Gene ID	8737
Unigene ID	Hs.519842
Probe set ID	209941_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000137275
GTEx ID	ENSG00000137275

オーソログ対応遺伝子

マウス[2]	NM_009068
ラット [0]

染色体

6p25.2 [3,064,092 - 3,115,421]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR000488	Death
IPR011029	DEATH-like
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0007257	activation of JUN kinase activity
GO:0006915	apoptosis
GO:0044257	cellular protein catabolic process
GO:0071356	cellular response to tumor necrosis factor
GO:0060555	induction of necroptosis by extracellular signals
GO:0045087	innate immune response
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043065	positive regulation of apoptosis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032757	positive regulation of interleukin-8 production
GO:0046330	positive regulation of JNK cascade
GO:0045651	positive regulation of macrophage differentiation
GO:0060545	positive regulation of necroptosis
GO:0010940	positive regulation of necrotic cell death
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0043068	positive regulation of programmed cell death
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032481	positive regulation of type I interferon production
GO:0046777	protein amino acid autophosphorylation
GO:0051291	protein heterooligomerization
GO:0051260	protein homooligomerization
GO:0070926	regulation of ATP:ADP antiporter activity
GO:0034612	response to tumor necrosis factor
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0033209	tumor necrosis factor-mediated signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0045121	membrane raft
GO:0005739	mitochondrion
GO:0043235	receptor complex

Molecular Function

GO:0005524	ATP binding
GO:0070513	death domain binding
GO:0005123	death receptor binding
GO:0042802	identical protein binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity

receptor (TNFRSF)-interacting serine-threonine kinase 1

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function