sphingosine kinase 1

詳細情報を見る

同義遺伝子名

sphingosine kinase 1, Sphingosine kinase 1, SPHK1, SPK 1, SPHK, SK 1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST nodata
GeneChip 大脳:6.38 小脳:6.24 脳幹:6.54 脳梁:6.32 松果体:- 末梢神経:7.01 脊柱:6.42 網膜:- 目:- 動脈:7.21 静脈:7.10 リンパ節:7.05 末梢血:- 脾臓:6.18 胸腺:6.31 骨髄:6.84 脂肪:6.90 骨:- 皮膚:6.94
CAGE 大脳:0.85 小脳:- 脳幹:1.27 脳梁:1.06 松果体:1.15 末梢神経:- 脊柱:0.76 網膜:- 目:- 動脈:1.97 静脈:1.61 リンパ節:1.85 末梢血:- 脾臓:0.71 胸腺:0.94 骨髄:- 脂肪:1.37 骨:- 皮膚:-
RNA-seq 大脳:0.09 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:1.07 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.60 骨:- 皮膚:-
EST nodata
GeneChip 子宮:6.42 胎盤:6.07 前立腺:6.06 卵巣:6.21 精巣:6.56 心臓:6.62 骨格筋:6.17 食道:7.43 胃:6.39 腸:6.58 結腸:6.61 肝臓:6.49 肺:7.13 膀胱:- 腎臓:6.28 下垂体:6.62 甲状腺:6.80 副腎:6.55 膵臓:6.38 乳腺:7.04 唾液腺:6.74
CAGE 子宮:0.86 胎盤:1.43 前立腺:1.03 卵巣:1.18 精巣:0.99 心臓:1.66 骨格筋:0.68 食道:1.48 胃:- 腸:1.24 結腸:0.90     肝臓:0.14    肺:1.62 膀胱:1.18 腎臓:0.62 下垂体:0 甲状腺:1.60 副腎:- 膵臓:1.59 乳腺:2.27 唾液腺:0.83
RNA-seq 子宮:- 胎盤:- 前立腺:0.78 卵巣:0.32 精巣:0.13 心臓:0.10 骨格筋:0 食道:- 胃:- 腸:- 結腸:0.00     肝臓:0.38        肺:2.18    膀胱:- 腎臓:0.00 下垂体:- 甲状腺:0.47 副腎:1.91 膵臓:- 乳腺:0.69 唾液腺:-

IDs

Refseq ID NM_001142602
Gene ID 8877
Unigene ID -
Probe set ID 219257_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000176170
GTEx ID ENSG00000176170

オーソログ対応遺伝子

マウス[2]  NM_001172472, NM_001172473, NM_001172475, NM_011451, NM_025367
ラット[1]  NM_133386, NM_001172473, NM_001172475, NM_011451, NM_025367

染色体

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

遺伝子オントロジー  (GO ID)

Biological Process

GO:0051084  'de novo' posttranslational protein folding
GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0001568  blood vessel development
GO:0007420  brain development
GO:0019722  calcium-mediated signaling
GO:0044267  cellular protein metabolic process
GO:0006954  inflammatory response
GO:0043066  negative regulation of apoptosis
GO:0045766  positive regulation of angiogenesis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0048146  positive regulation of fibroblast proliferation
GO:0045931  positive regulation of mitotic cell cycle
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0031398  positive regulation of protein ubiquitination
GO:0045987  positive regulation of smooth muscle contraction
GO:0006457  protein folding
GO:0032651  regulation of interleukin-1 beta production
GO:0010803  regulation of tumor necrosis factor-mediated signaling pathway
GO:0007165  signal transduction
GO:0046521  sphingoid catabolic process
GO:0030148  sphingolipid biosynthetic process
GO:0006665  sphingolipid metabolic process
GO:0006670  sphingosine metabolic process

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0017050  D-erythro-sphingosine kinase activity
GO:0004143  diacylglycerol kinase activity
GO:0003677  DNA binding
GO:0000287  magnesium ion binding
GO:0005515  protein binding
GO:0051721  protein phosphatase 2A binding
GO:0008481  sphinganine kinase activity