activin A receptor, type IB

 詳細情報を見る

同義遺伝子名

ALK-4, ACVRLK4, ACVR1B, Activin receptor type 1B precursor, Activin receptor-like kinase 4, ALK4, activin A receptor, type IB, Serine/threonine-protein kinase receptor R2, SKR2, ACTR-IB, ACTRIB

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:83 小脳:37.80 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:52.90 動脈:- 静脈:- リンパ節:10.10 末梢血:18.20 脾臓:18.90 胸腺:25.80 骨髄:59 脂肪:- 骨:- 皮膚:76.80
GeneChip 大脳:4.52 小脳:4.41 脳幹:4.59 脳梁:4.29 松果体:- 末梢神経:4.36 脊柱:4.35 網膜:- 目:- 動脈:4.57 静脈:4.73 リンパ節:4.28 末梢血:- 脾臓:4.31 胸腺:4.23 骨髄:4.58 脂肪:4.59 骨:- 皮膚:4.57
CAGE 大脳:2.90 小脳:- 脳幹:2.24 脳梁:2.14 松果体:2.90 末梢神経:- 脊柱:2.21 網膜:- 目:- 動脈:2.95 静脈:2.11 リンパ節:2.55 末梢血:- 脾臓:2.23 胸腺:1.75 骨髄:- 脂肪:2.61 骨:- 皮膚:-
RNA-seq 大脳:0.37 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:0.27 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:0.49 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:9.10 胎盤:18.20 前立腺:56.30 卵巣:37.30 精巣:47.60 心臓:25.50 骨格筋:20.10 食道:- 胃:85 腸:- 結腸:93.30     肝臓:10.60        肺:29.30    膀胱:- 腎臓:135.20 下垂体:- 甲状腺:- 副腎:- 膵臓:53.30 乳腺:195.20 唾液腺:-
GeneChip 子宮:4.32 胎盤:4.19 前立腺:4.32 卵巣:4.36 精巣:4.54 心臓:4.54 骨格筋:4.66 食道:4.51 胃:4.45 腸:4.44 結腸:4.76 肝臓:4.40 肺:4.37 膀胱:- 腎臓:4.59 下垂体:4.48 甲状腺:4.30 副腎:4.37 膵臓:4.58 乳腺:4.41 唾液腺:4.45
CAGE 子宮:2.34 胎盤:1.39 前立腺:2.66 卵巣:2.43 精巣:2.73 心臓:2.43 骨格筋:2.64 食道:2.79 胃:- 腸:3.33 結腸:3.37     肝臓:3.18    肺:2.61 膀胱:2.55 腎臓:3.43 下垂体:2.87 甲状腺:2.65 副腎:- 膵臓:3.78 乳腺:3.02 唾液腺:3.45
RNA-seq 子宮:- 胎盤:- 前立腺:0.08 卵巣:0.54 精巣:0.73 心臓:0.05 骨格筋:0.00 食道:- 胃:- 腸:- 結腸:0.05     肝臓:0.00        肺:0.21    膀胱:- 腎臓:0.42 下垂体:- 甲状腺:0.59 副腎:0.29 膵臓:- 乳腺:0.19 唾液腺:-

詳細情報

IDs

Refseq ID NM_020328
Gene ID 91
Unigene ID Hs.438918
Probe set ID 208218_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135503
GTEx ID ENSG00000135503

オーソログ対応遺伝子

マウス[1]  NM_007395
ラット [0]  

染色体

12q13.13  [52,345,451  -  52,390,862]

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7791754
7890768
8058741
8196624
8397373
8612709
8622651
9032295
9202237
9501322
9738003
9884026
9892009
10652306
11117535
11248065
11266516
11278302
11279102
11356828
11389842
11909953
11969340
12023024
12032389
12065756
12112843
12364468
12477932
12639945
12651901
12665502
12857866
12919325
14517293
15123686
15196700
15459392
15489334
15611116
15908921
16720724
17906079
18039968
19035567
19322201
19758997
19953087
20226172
20347265
20379614
20596523
20663871
20734064
20819778
21063444
21377836
21791611
21988832
22267736
22939624
23010638
23159635
23211491
23263486

遺伝子オントロジー  (GO ID)

Biological Process

GO:0032924  activin receptor signaling pathway
GO:0007417  central nervous system development
GO:0046545  development of primary female sexual characteristics
GO:0000082  G1/S transition of mitotic cell cycle
GO:0001942  hair follicle development
GO:0001701  in utero embryonic development
GO:0030308  negative regulation of cell growth
GO:0018107  peptidyl-threonine phosphorylation
GO:0032927  positive regulation of activin receptor signaling pathway
GO:0045648  positive regulation of erythrocyte differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0006355  regulation of transcription, DNA-dependent
GO:0007165  signal transduction
GO:0007178  transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0048185  activin binding
GO:0017002  activin receptor activity
GO:0016361  activin receptor activity, type I
GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0034711  inhibin binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0004702  receptor signaling protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0005024  transforming growth factor beta receptor activity
GO:0004675  transmembrane receptor protein serine/threonine kinase activity
GO:0031625  ubiquitin protein ligase binding