bone morphogenetic protein 4

 詳細情報を見る

同義遺伝子名

Bmp2b1, Bmp-4, Bone morphogenetic protein 4 precursor, Bmp4, BMP-2B, Dvr-4, bone morphogenetic protein 4, Bmp2b-1, Bmp2b, BMP-4

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:5.20 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:32.40 末梢血:57.50 脾臓:302.80 胸腺:247 骨髄:153.90 脂肪:- 骨:- 皮膚:23.80
GeneChip 大脳:5.74 小脳:5.64 脳幹:- 脳梁:- 松果体:- 末梢神経:5.53 脊柱:5.80 網膜:7.31 目:6.95 動脈:- 静脈:9.26 リンパ節:6.16 末梢血:- 脾臓:7.05 胸腺:- 骨髄:6.21 脂肪:6.46 骨:6.33 皮膚:8.79
CAGE 大脳:0.10 小脳:- 脳幹:0.55 脳梁:- 松果体:- 末梢神経:- 脊柱:0.44 網膜:- 目:- 動脈:2.14 静脈:- リンパ節:0.23 末梢血:- 脾臓:0.29 胸腺:0.27 骨髄:- 脂肪:- 骨:0.63 皮膚:2.29
RNA-seq 大脳:1.14 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:- 前立腺:- 卵巣:195.30 精巣:29.60 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:30.10    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:6.50 唾液腺:-
GeneChip 子宮:7.72 胎盤:7.58 前立腺:7.87 卵巣:6.93 精巣:5.94 心臓:6.90 骨格筋:6.95 食道:- 胃:8.79 腸:8.30 結腸:- 肝臓:6.20 肺:9.49 膀胱:9.34 腎臓:9.29 下垂体:5.53 甲状腺:- 副腎:7.53 膵臓:6.10 乳腺:6.15 唾液腺:7.64
CAGE 子宮:1.10 胎盤:1.10 前立腺:1.23 卵巣:0.54 精巣:0 心臓:- 骨格筋:- 食道:- 胃:2.44 腸:1.05 結腸:1.72     肝臓:0.64    肺:3.00 膀胱:2.44 腎臓:- 下垂体:0.52 甲状腺:- 副腎:1.02 膵臓:0.84 乳腺:0 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.70 食道:- 胃:- 腸:- 結腸:-     肝臓:1.29        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_007554
Gene ID 12159
Unigene ID Mm.68134
Probe set ID 1422912_at  [Mouse430_2]
Ensembl ID ENSMUSG00000021835

オーソログ対応遺伝子

ヒト[3]  NM_001202, NM_130850, NM_130851
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0048646  anatomical structure formation involved in morphogenesis
GO:0001525  angiogenesis
GO:0009948  anterior/posterior axis specification
GO:0001568  blood vessel development
GO:0002043  blood vessel endothelial cell proliferation during sprouting angiogenesis
GO:0030509  BMP signaling pathway
GO:0003130  BMP signaling pathway involved in heart induction
GO:0060348  bone development
GO:0060441  branching involved in lung morphogenesis
GO:0060442  branching involved in prostate gland morphogenesis
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0048754  branching morphogenesis of a tube
GO:0060433  bronchus development
GO:0060503  bud dilation involved in lung branching
GO:0060449  bud elongation involved in lung branching
GO:0043010  camera-type eye development
GO:0048593  camera-type eye morphogenesis
GO:0055007  cardiac muscle cell differentiation
GO:0051216  cartilage development
GO:0030154  cell differentiation
GO:0045165  cell fate commitment
GO:0071363  cellular response to growth factor stimulus
GO:0002062  chondrocyte differentiation
GO:0007182  common-partner SMAD protein phosphorylation
GO:0060363  cranial suture morphogenesis
GO:0021904  dorsal/ventral neural tube patterning
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0042733  embryonic digit morphogenesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0030326  embryonic limb morphogenesis
GO:0048598  embryonic morphogenesis
GO:0060272  embryonic skeletal joint morphogenesis
GO:0048706  embryonic skeletal system development
GO:0048704  embryonic skeletal system morphogenesis
GO:0001958  endochondral ossification
GO:0060502  epithelial cell proliferation involved in lung morphogenesis
GO:0060684  epithelial-mesenchymal cell signaling
GO:0060429  epithelium development
GO:0030218  erythrocyte differentiation
GO:0001654  eye development
GO:0030900  forebrain development
GO:0007281  germ cell development
GO:0040007  growth
GO:0007507  heart development
GO:0002244  hemopoietic progenitor cell differentiation
GO:0001759  induction of an organ
GO:0060113  inner ear receptor cell differentiation
GO:0048392  intermediate mesodermal cell differentiation
GO:0001822  kidney development
GO:0060235  lens induction in camera-type eye
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060425  lung morphogenesis
GO:0002320  lymphoid progenitor cell differentiation
GO:0030225  macrophage differentiation
GO:0060592  mammary gland formation
GO:0003337  mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0001707  mesoderm formation
GO:0048333  mesodermal cell differentiation
GO:0007500  mesodermal cell fate determination
GO:0001656  metanephros development
GO:0030224  monocyte differentiation
GO:0007275  multicellular organismal development
GO:0043066  negative regulation of apoptosis
GO:0090191  negative regulation of branching involved in ureteric bud morphogenesis
GO:0045786  negative regulation of cell cycle
GO:0060548  negative regulation of cell death
GO:0008285  negative regulation of cell proliferation
GO:0032331  negative regulation of chondrocyte differentiation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010629  negative regulation of gene expression
GO:0090194  negative regulation of glomerulus development
GO:0033088  negative regulation of immature T cell proliferation in the thymus
GO:0043407  negative regulation of MAP kinase activity
GO:0045839  negative regulation of mitosis
GO:0045662  negative regulation of myoblast differentiation
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0042326  negative regulation of phosphorylation
GO:0060686  negative regulation of prostatic bud formation
GO:0045843  negative regulation of striated muscle tissue development
GO:0033085  negative regulation of T cell differentiation in the thymus
GO:0070244  negative regulation of thymocyte apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0001843  neural tube closure
GO:0048663  neuron fate commitment
GO:0042476  odontogenesis
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001503  ossification
GO:0001649  osteoblast differentiation
GO:0001541  ovarian follicle development
GO:0003323  pancreatic B cell development
GO:0021983  pituitary gland development
GO:0050918  positive chemotaxis
GO:0043065  positive regulation of apoptosis
GO:0030513  positive regulation of BMP signaling pathway
GO:0030501  positive regulation of bone mineralization
GO:0090190  positive regulation of branching involved in ureteric bud morphogenesis
GO:0055020  positive regulation of cardiac muscle fiber development
GO:0010942  positive regulation of cell death
GO:0045597  positive regulation of cell differentiation
GO:0008284  positive regulation of cell proliferation
GO:0032967  positive regulation of collagen biosynthetic process
GO:0045603  positive regulation of endothelial cell differentiation
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010628  positive regulation of gene expression
GO:0090184  positive regulation of kidney development
GO:0045666  positive regulation of neuron differentiation
GO:0045778  positive regulation of ossification
GO:0045669  positive regulation of osteoblast differentiation
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0009791  post-embryonic development
GO:0060512  prostate gland morphogenesis
GO:0034504  protein localization in nucleus
GO:0060687  regulation of branching involved in prostate gland morphogenesis
GO:0045595  regulation of cell differentiation
GO:0001936  regulation of endothelial cell proliferation
GO:0010468  regulation of gene expression
GO:0060688  regulation of morphogenesis of a branching structure
GO:0042487  regulation of odontogenesis of dentine-containing tooth
GO:0060393  regulation of pathway-restricted SMAD protein phosphorylation
GO:0051150  regulation of smooth muscle cell differentiation
GO:0048660  regulation of smooth muscle cell proliferation
GO:0003014  renal system process
GO:0003139  secondary heart field specification
GO:0001501  skeletal system development
GO:0060395  SMAD protein signal transduction
GO:0051145  smooth muscle cell differentiation
GO:0048745  smooth muscle tissue development
GO:0010159  specification of organ position
GO:0043401  steroid hormone mediated signaling pathway
GO:0021537  telencephalon development
GO:0021978  telencephalon regionalization
GO:0009888  tissue development
GO:0060438  trachea development
GO:0060440  trachea formation
GO:0001657  ureteric bud development
GO:0001944  vasculature development

Cellular Component

GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0031988  membrane-bounded vesicle
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0070700  BMP receptor binding
GO:0042056  chemoattractant activity
GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0008201  heparin binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity