epidermal growth factor receptor

同義遺伝子名

epidermal growth factor receptor, wa-2, Erbb, 9030024J15Rik, AI552599, Epidermal growth factor receptor precursor, Egfr, Errp, Wa5, wa2

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:41.70

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:30.40

動脈:-

静脈:-

リンパ節:-

末梢血:14.40

脾臓:13.20

胸腺:19.80

骨髄:-

脂肪:212.70

骨:-

皮膚:87.10

GeneChip

大脳:7.39

小脳:7.50

脳幹:-

脳梁:-

松果体:-

末梢神経:7.33

脊柱:7.56

網膜:7.13

目:7.60

動脈:-

静脈:7.96

リンパ節:7.45

末梢血:-

脾臓:7.44

胸腺:-

骨髄:7.52

脂肪:8.23

骨:7.71

皮膚:8.50

CAGE

大脳:2.48

小脳:-

脳幹:2.85

脳梁:-

松果体:-

末梢神経:-

脊柱:2.60

網膜:-

目:-

動脈:3.42

静脈:-

リンパ節:2.76

末梢血:-

脾臓:1.41

胸腺:2.70

骨髄:-

脂肪:-

骨:2.19

皮膚:4.96

RNA-seq

大脳:2.05

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:55.20

前立腺:-

卵巣:126.40

精巣:36.90

心臓:18.60

骨格筋:-

食道:-

胃:-

腸:-

結腸:17.60

肝臓:181

肺:20.10

膀胱:-

腎臓:40.30

下垂体:12.90

甲状腺:-

副腎:-

膵臓:37.50

乳腺:35.90

唾液腺:-

GeneChip

子宮:7.94

胎盤:8.78

前立腺:7.98

卵巣:7.89

精巣:7.75

心臓:8.16

骨格筋:8.53

食道:-

胃:8.31

腸:8.06

結腸:-

肝臓:11.73

肺:8.05

膀胱:7.95

腎臓:8.62

下垂体:8.07

甲状腺:-

副腎:7.75

膵臓:8.65

乳腺:8.25

唾液腺:8.39

CAGE

子宮:3.88

胎盤:3.75

前立腺:3.64

卵巣:4.03

精巣:0.99

心臓:-

骨格筋:-

食道:-

胃:3.25

腸:2.96

結腸:3.39

肝臓:6.02

肺:3.24

膀胱:3.79

腎臓:-

下垂体:3.38

甲状腺:-

副腎:2.64

膵臓:3.53

乳腺:3.52

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:2.09

食道:-

胃:-

腸:-

結腸:-

肝臓:27.72

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_007912
Gene ID	13649
Unigene ID	Mm.8534
Probe set ID	1460420_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000020122

オーソログ対応遺伝子

ヒト[11]	NM_005228, NM_201282, NM_201283, NM_201284
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0000186	activation of MAPKK activity
GO:0048143	astrocyte activation
GO:0000902	cell morphogenesis
GO:0008283	cell proliferation
GO:0007166	cell surface receptor linked signal transduction
GO:0016337	cell-cell adhesion
GO:0021795	cerebral cortex cell migration
GO:0048546	digestive tract morphogenesis
GO:0001892	embryonic placenta development
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0001942	hair follicle development
GO:0010960	magnesium ion homeostasis
GO:0060571	morphogenesis of an epithelial fold
GO:0007275	multicellular organismal development
GO:0043066	negative regulation of apoptosis
GO:0045930	negative regulation of mitotic cell cycle
GO:0042177	negative regulation of protein catabolic process
GO:0048812	neuron projection morphogenesis
GO:0042698	ovulation cycle
GO:0016310	phosphorylation
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0031659	positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0045739	positive regulation of DNA repair
GO:0045740	positive regulation of DNA replication
GO:0050679	positive regulation of epithelial cell proliferation
GO:0048146	positive regulation of fibroblast proliferation
GO:0050729	positive regulation of inflammatory response
GO:0043406	positive regulation of MAP kinase activity
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0042327	positive regulation of phosphorylation
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0032930	positive regulation of superoxide release
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0045907	positive regulation of vasoconstriction
GO:0045909	positive regulation of vasodilation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0007243	protein kinase cascade
GO:0042127	regulation of cell proliferation
GO:0050999	regulation of nitric-oxide synthase activity
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0051592	response to calcium ion
GO:0070141	response to UV-A
GO:0007435	salivary gland morphogenesis
GO:0007165	signal transduction
GO:0006412	translation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0016324	apical plasma membrane
GO:0016323	basolateral plasma membrane
GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0030139	endocytic vesicle
GO:0005783	endoplasmic reticulum
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0016021	integral to membrane
GO:0005622	intracellular
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0051015	actin filament binding
GO:0005524	ATP binding
GO:0019899	enzyme binding
GO:0048408	epidermal growth factor binding
GO:0005006	epidermal growth factor receptor activity
GO:0001948	glycoprotein binding
GO:0042802	identical protein binding
GO:0005178	integrin binding
GO:0016301	kinase activity
GO:0030235	nitric-oxide synthase regulator activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0004713	protein tyrosine kinase activity
GO:0005102	receptor binding
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0004888	transmembrane receptor activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity

epidermal growth factor receptor

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function