epidermal growth factor receptor

詳細情報を見る

同義遺伝子名

epidermal growth factor receptor, wa-2, Erbb, 9030024J15Rik, AI552599, Epidermal growth factor receptor precursor, Egfr, Errp, Wa5, wa2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:4.71 小脳:4.95 脳幹:- 脳梁:- 松果体:- 末梢神経:4.61 脊柱:4.82 網膜:4.40 目:6.75 動脈:- 静脈:7.07 リンパ節:4.99 末梢血:- 脾臓:4.44 胸腺:- 骨髄:4.07 脂肪:6.85 骨:4.73 皮膚:8.46
CAGE 大脳:2.48 小脳:- 脳幹:2.85 脳梁:- 松果体:- 末梢神経:- 脊柱:2.60 網膜:- 目:- 動脈:3.42 静脈:- リンパ節:2.76 末梢血:- 脾臓:1.41 胸腺:2.70 骨髄:- 脂肪:- 骨:2.19 皮膚:4.96
RNA-seq 大脳:2.05 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:7.35 胎盤:7.63 前立腺:6.40 卵巣:6.99 精巣:4.14 心臓:5.13 骨格筋:6.68 食道:- 胃:6.78 腸:6.93 結腸:- 肝臓:10.78 肺:6.81 膀胱:6.91 腎臓:7.36 下垂体:5.66 甲状腺:- 副腎:4.74 膵臓:4.81 乳腺:7.07 唾液腺:6.75
CAGE 子宮:3.88 胎盤:3.75 前立腺:3.64 卵巣:4.03 精巣:0.99 心臓:- 骨格筋:- 食道:- 胃:3.25 腸:2.96 結腸:3.39     肝臓:6.02    肺:3.24 膀胱:3.79 腎臓:- 下垂体:3.38 甲状腺:- 副腎:2.64 膵臓:3.53 乳腺:3.52 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:2.09 食道:- 胃:- 腸:- 結腸:-     肝臓:27.72        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_207655
Gene ID 13649
Unigene ID Mm.420648
Probe set ID 1424932_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020122

オーソログ対応遺伝子

ヒト[11]  NM_005228, NM_201282, NM_201283, NM_201284
ラット [0]  

染色体

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遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1311971
1321343
1349581
1408137
1426645
1459205
1477476
1633114
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0000186  activation of MAPKK activity
GO:0048143  astrocyte activation
GO:0000902  cell morphogenesis
GO:0008283  cell proliferation
GO:0007166  cell surface receptor linked signal transduction
GO:0016337  cell-cell adhesion
GO:0021795  cerebral cortex cell migration
GO:0048546  digestive tract morphogenesis
GO:0001892  embryonic placenta development
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008544  epidermis development
GO:0001942  hair follicle development
GO:0010960  magnesium ion homeostasis
GO:0060571  morphogenesis of an epithelial fold
GO:0007275  multicellular organismal development
GO:0043066  negative regulation of apoptosis
GO:0045930  negative regulation of mitotic cell cycle
GO:0042177  negative regulation of protein catabolic process
GO:0048812  neuron projection morphogenesis
GO:0042698  ovulation cycle
GO:0016310  phosphorylation
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0031659  positive regulation of cyclin-dependent protein kinase activity during G1/S
GO:0045739  positive regulation of DNA repair
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0050729  positive regulation of inflammatory response
GO:0043406  positive regulation of MAP kinase activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0042327  positive regulation of phosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0032930  positive regulation of superoxide release
GO:0051968  positive regulation of synaptic transmission, glutamatergic
GO:0045907  positive regulation of vasoconstriction
GO:0045909  positive regulation of vasodilation
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0042127  regulation of cell proliferation
GO:0050999  regulation of nitric-oxide synthase activity
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0051592  response to calcium ion
GO:0070141  response to UV-A
GO:0007435  salivary gland morphogenesis
GO:0007165  signal transduction
GO:0006412  translation
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway

Cellular Component

GO:0016324  apical plasma membrane
GO:0016323  basolateral plasma membrane
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0030139  endocytic vesicle
GO:0005783  endoplasmic reticulum
GO:0005768  endosome
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005622  intracellular
GO:0016020  membrane
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0051015  actin filament binding
GO:0005524  ATP binding
GO:0019899  enzyme binding
GO:0048408  epidermal growth factor binding
GO:0005006  epidermal growth factor receptor activity
GO:0001948  glycoprotein binding
GO:0042802  identical protein binding
GO:0005178  integrin binding
GO:0016301  kinase activity
GO:0030235  nitric-oxide synthase regulator activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0019903  protein phosphatase binding
GO:0004713  protein tyrosine kinase activity
GO:0005102  receptor binding
GO:0004716  receptor signaling protein tyrosine kinase activity
GO:0004871  signal transducer activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004888  transmembrane receptor activity
GO:0004714  transmembrane receptor protein tyrosine kinase activity