v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

同義遺伝子名

c-erbB2, Erbb-2, Neu oncogene, HER2, Kiaa3023, HER-2, C-erbB-2, Receptor tyrosine-protein kinase erbB-2 precursor, ErbB-2, NEU proto-oncogene, mKIAA3023, Erbb2, c-neu, p185erbB2, Neu

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:27.80

小脳:18.40

脳幹:-

脳梁:-

松果体:-

末梢神経:19.10

脊柱:-

網膜:32.10

目:15.20

動脈:-

静脈:-

リンパ節:10.80

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:50.10

皮膚:39.60

GeneChip

大脳:5.49

小脳:5.71

脳幹:-

脳梁:-

松果体:-

末梢神経:6.18

脊柱:5.55

網膜:5.55

目:6.76

動脈:-

静脈:7.21

リンパ節:5.76

末梢血:-

脾臓:5.66

胸腺:-

骨髄:5.46

脂肪:6.44

骨:5.32

皮膚:8.39

CAGE

大脳:0.94

小脳:-

脳幹:0.68

脳梁:-

松果体:-

末梢神経:-

脊柱:1.33

網膜:-

目:-

動脈:1.89

静脈:-

リンパ節:1.03

末梢血:-

脾臓:0.93

胸腺:0.27

骨髄:-

脂肪:-

骨:0

皮膚:4.05

RNA-seq

大脳:23.07

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:41.40

前立腺:-

卵巣:11.50

精巣:14.80

心臓:18.60

骨格筋:-

食道:-

胃:130.90

腸:-

結腸:88.10

肝臓:27.20

肺:40.20

膀胱:-

腎臓:64.50

下垂体:12.90

甲状腺:-

副腎:-

膵臓:-

乳腺:169.80

唾液腺:-

GeneChip

子宮:8.03

胎盤:5.94

前立腺:8.20

卵巣:7.02

精巣:5.89

心臓:6.51

骨格筋:6.11

食道:-

胃:8.43

腸:8.76

結腸:-

肝臓:5.37

肺:7.03

膀胱:7.56

腎臓:7.67

下垂体:5.97

甲状腺:-

副腎:5.93

膵臓:5.93

乳腺:6.82

唾液腺:7.75

CAGE

子宮:3.47

胎盤:1.95

前立腺:3.14

卵巣:2.87

精巣:0.45

心臓:-

骨格筋:-

食道:-

胃:3.32

腸:3.68

結腸:4.16

肝臓:1.12

肺:2.93

膀胱:3.31

腎臓:-

下垂体:1.40

甲状腺:-

副腎:1.42

膵臓:1.30

乳腺:2.54

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:5.01

食道:-

胃:-

腸:-

結腸:-

肝臓:1.50

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_001003817
Gene ID	13866
Unigene ID	Mm.290822
Probe set ID	1424919_at [Mouse430_2]
Ensembl ID	ENSMUSG00000062312

オーソログ対応遺伝子

ヒト[4]	NM_001005862, NM_004448
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0007166	cell surface receptor linked signal transduction
GO:0060209	estrus
GO:0010001	glial cell differentiation
GO:0007507	heart development
GO:0008045	motor axon guidance
GO:0042552	myelination
GO:0043066	negative regulation of apoptosis
GO:0033088	negative regulation of immature T cell proliferation in the thymus
GO:0007399	nervous system development
GO:0007528	neuromuscular junction development
GO:0007422	peripheral nervous system development
GO:0014065	phosphoinositide 3-kinase cascade
GO:0016310	phosphorylation
GO:0045785	positive regulation of cell adhesion
GO:0030307	positive regulation of cell growth
GO:0008284	positive regulation of cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPKKK cascade
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0046579	positive regulation of Ras protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0045943	positive regulation of transcription from RNA polymerase I promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0045727	positive regulation of translation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0032886	regulation of microtubule-based process
GO:0006355	regulation of transcription, DNA-dependent
GO:0048678	response to axon injury
GO:0007165	signal transduction
GO:0048485	sympathetic nervous system development
GO:0006351	transcription, DNA-dependent
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060	wound healing

Cellular Component

GO:0016324	apical plasma membrane
GO:0009925	basal plasma membrane
GO:0016323	basolateral plasma membrane
GO:0005737	cytoplasm
GO:0010008	endosome membrane
GO:0016021	integral to membrane
GO:0043219	lateral loop
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005902	microvillus
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0045211	postsynaptic membrane
GO:0043235	receptor complex

Molecular Function

GO:0005524	ATP binding
GO:0001948	glycoprotein binding
GO:0019838	growth factor binding
GO:0051879	Hsp90 protein binding
GO:0042802	identical protein binding
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0046982	protein heterodimerization activity
GO:0004672	protein kinase activity
GO:0019903	protein phosphatase binding
GO:0004713	protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0004888	transmembrane receptor activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0031625	ubiquitin protein ligase binding

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function