FMS-like tyrosine kinase 4

詳細情報を見る

同義遺伝子名

Flt-4, AI323512, Flt4, Tyrosine-protein kinase receptor FLT4, VEGFR-3, FMS-like tyrosine kinase 4, VEGFR3, Chy

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:5.20 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:19.10 脊柱:- 網膜:- 目:7.60 動脈:- 静脈:- リンパ節:- 末梢血:14.40 脾臓:- 胸腺:9.90 骨髄:- 脂肪:- 骨:62.60 皮膚:-
GeneChip 大脳:5.13 小脳:5.22 脳幹:- 脳梁:- 松果体:- 末梢神経:5.20 脊柱:5.36 網膜:5.14 目:5.44 動脈:- 静脈:5.29 リンパ節:6.81 末梢血:- 脾臓:5.33 胸腺:- 骨髄:5.94 脂肪:5.31 骨:5.53 皮膚:5.18
CAGE 大脳:1.05 小脳:- 脳幹:1.21 脳梁:- 松果体:- 末梢神経:- 脊柱:1.28 網膜:- 目:- 動脈:2.38 静脈:- リンパ節:3.20 末梢血:- 脾臓:2.20 胸腺:0.95 骨髄:- 脂肪:- 骨:2.77 皮膚:1.50
RNA-seq 大脳:1.21 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:37.20 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:9.10        肺:-    膀胱:- 腎臓:- 下垂体:12.90 甲状腺:- 副腎:- 膵臓:18.80 乳腺:49 唾液腺:-
GeneChip 子宮:5.29 胎盤:6.23 前立腺:5.37 卵巣:5.12 精巣:5.51 心臓:5.92 骨格筋:5.47 食道:- 胃:5.46 腸:5.35 結腸:- 肝臓:6.10 肺:5.82 膀胱:5.27 腎臓:5.43 下垂体:5.44 甲状腺:- 副腎:5.32 膵臓:6 乳腺:5.34 唾液腺:5.47
CAGE 子宮:2.64 胎盤:3.64 前立腺:1.56 卵巣:2.70 精巣:0 心臓:- 骨格筋:- 食道:- 胃:1.35 腸:2.13 結腸:1.72     肝臓:3.52    肺:3.18 膀胱:2.65 腎臓:- 下垂体:2.42 甲状腺:- 副腎:3.40 膵臓:0.84 乳腺:1.82 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.48 食道:- 胃:- 腸:- 結腸:-     肝臓:2.61        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_008029
Gene ID 14257
Unigene ID Mm.329100
Probe set ID 1421442_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020357

オーソログ対応遺伝子

ヒト[2]  NM_002020, NM_182925
ラット[1]  NM_053652, NM_182925

染色体

-

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0048514  blood vessel morphogenesis
GO:0001945  lymph vessel development
GO:0001946  lymphangiogenesis
GO:0043066  negative regulation of apoptosis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0016310  phosphorylation
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046330  positive regulation of JNK cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0090037  positive regulation of protein kinase C signaling cascade
GO:0010575  positive regulation vascular endothelial growth factor production
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0060312  regulation of blood vessel remodeling
GO:0002040  sprouting angiogenesis
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway
GO:0001944  vasculature development

Cellular Component

GO:0005737  cytoplasm
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0019838  growth factor binding
GO:0016301  kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0019903  protein phosphatase binding
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity
GO:0005021  vascular endothelial growth factor receptor activity