3-hydroxy-3-methylglutaryl-Coenzyme A reductase

同義遺伝子名

Red, 3-hydroxy-3-methylglutaryl-CoA reductase, Hmgcr, MGC103269, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMG-CoAR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

nodata

GeneChip

大脳:7.67

小脳:6.45

脳幹:-

脳梁:-

松果体:-

末梢神経:8.57

脊柱:7.34

網膜:6.62

目:6.47

動脈:-

静脈:6.89

リンパ節:7.08

末梢血:-

脾臓:6.49

胸腺:-

骨髄:7.04

脂肪:5.99

骨:6.83

皮膚:8.10

CAGE

大脳:3.84

小脳:-

脳幹:3.95

脳梁:-

松果体:-

末梢神経:-

脊柱:4.05

網膜:-

目:-

動脈:2.61

静脈:-

リンパ節:3.30

末梢血:-

脾臓:3.24

胸腺:3.85

骨髄:-

脂肪:-

骨:3.69

皮膚:3.69

RNA-seq

大脳:8.48

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

nodata

GeneChip

子宮:6.13

胎盤:7.69

前立腺:5.96

卵巣:7.91

精巣:7.19

心臓:4.79

骨格筋:5.25

食道:-

胃:7.75

腸:8.42

結腸:-

肝臓:7.93

肺:6.98

膀胱:6.36

腎臓:7.70

下垂体:7.04

甲状腺:-

副腎:6.69

膵臓:5.49

乳腺:5.71

唾液腺:5.08

CAGE

子宮:3.51

胎盤:3.69

前立腺:2.59

卵巣:3.74

精巣:4.53

心臓:-

骨格筋:-

食道:-

胃:3.85

腸:4.05

結腸:3.92

肝臓:4.90

肺:3.32

膀胱:3.11

腎臓:-

下垂体:3.70

甲状腺:-

副腎:3.44

膵臓:2.33

乳腺:3.17

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.28

食道:-

胃:-

腸:-

結腸:-

肝臓:6.40

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_008255
Gene ID	15357
Unigene ID	-
Probe set ID	1427229_at [Mouse430_2]
Ensembl ID	ENSMUSG00000021670

オーソログ対応遺伝子

ヒト[4]	NM_000859, NM_001130996
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR004554	Hydroxymethylglutaryl-CoA reductase, class I, catalytic
IPR002202	Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0015936	coenzyme A metabolic process
GO:0009790	embryonic development
GO:0008299	isoprenoid biosynthetic process
GO:0006629	lipid metabolic process
GO:0043066	negative regulation of apoptosis
GO:0043407	negative regulation of MAP kinase activity
GO:0010664	negative regulation of striated muscle cell apoptosis
GO:0045908	negative regulation of vasodilation
GO:0055114	oxidation reduction
GO:0010666	positive regulation of cardiac muscle cell apoptosis
GO:0008284	positive regulation of cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0051262	protein tetramerization
GO:0006694	steroid biosynthetic process
GO:0008202	steroid metabolic process
GO:0016126	sterol biosynthetic process
GO:0006743	ubiquinone metabolic process
GO:0008542	visual learning

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral to membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0016020	membrane
GO:0005778	peroxisomal membrane

Molecular Function

GO:0050662	coenzyme binding
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0042282	hydroxymethylglutaryl-CoA reductase activity
GO:0050661	NADP or NADPH binding
GO:0070402	NADPH binding
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function