insulin-like growth factor 1

詳細情報を見る

同義遺伝子名

Insulin-like growth factor I precursor, Igf1, Igf-I, IGF-I, C730016P09Rik, Igf-1, Somatomedin, insulin-like growth factor 1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:22.60 小脳:128.90 脳幹:- 脳梁:- 松果体:- 末梢神経:152.90 脊柱:- 網膜:- 目:114 動脈:168.80 静脈:- リンパ節:162 末梢血:14.40 脾臓:52.70 胸腺:98.80 骨髄:12.80 脂肪:212.70 骨:12.50 皮膚:39.60
GeneChip 大脳:5.82 小脳:5.59 脳幹:- 脳梁:- 松果体:- 末梢神経:6.06 脊柱:5.60 網膜:5.65 目:6.69 動脈:- 静脈:9.24 リンパ節:9.40 末梢血:- 脾臓:8.35 胸腺:- 骨髄:7.98 脂肪:10.17 骨:7.97 皮膚:6.85
CAGE 大脳:2.08 小脳:- 脳幹:2.64 脳梁:- 松果体:- 末梢神経:- 脊柱:2.79 網膜:- 目:- 動脈:5.24 静脈:- リンパ節:5.59 末梢血:- 脾臓:4.37 胸腺:3.95 骨髄:- 脂肪:- 骨:3.81 皮膚:4.82
RNA-seq 大脳:3.86 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:123.50 卵巣:57.50 精巣:36.90 心臓:74.40 骨格筋:106.50 食道:- 胃:32.70 腸:- 結腸:-     肝臓:380.10        肺:90.40    膀胱:66.20 腎臓:24.20 下垂体:- 甲状腺:- 副腎:- 膵臓:403.40 乳腺:55.50 唾液腺:-
GeneChip 子宮:9.85 胎盤:6.10 前立腺:7.17 卵巣:9.51 精巣:6.57 心臓:7.19 骨格筋:8.38 食道:- 胃:7.34 腸:5.89 結腸:- 肝臓:12.49 肺:7.95 膀胱:7.61 腎臓:6.53 下垂体:6.20 甲状腺:- 副腎:7.67 膵臓:10.67 乳腺:9.28 唾液腺:7.92
CAGE 子宮:6.16 胎盤:2.62 前立腺:4.59 卵巣:5.60 精巣:2.46 心臓:- 骨格筋:- 食道:- 胃:4.54 腸:2.96 結腸:3.55     肝臓:7.72    肺:3.43 膀胱:4.65 腎臓:- 下垂体:1.86 甲状腺:- 副腎:4.10 膵臓:6.21 乳腺:4.23 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:4.15 食道:- 胃:- 腸:- 結腸:-     肝臓:47.15        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_001111274
Gene ID 16000
Unigene ID Mm.268521
Probe set ID 1452014_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000020053

オーソログ対応遺伝子

ヒト[14]  NM_000618, NM_001111283, NM_001111284, NM_001111285
ラット[12]  NM_001082477, NM_001082478, NM_001082479, NM_178866

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1284245
1315903
1317321
1374351
1601577
1628813
1698554
1701096
1778592
1924386
1975791
2004558
2474537
2767428
3313091
3467309
3595538
3774549
7038514
7472488
7510770
7522842
7525256
7525829
7525909
7545402
7588220
7595602
7601910
7613482
7636260
7640658
7664676
7679139
7691099
7718235
7744859
7750499
7763295
7789774
7806275
7819129
7819439
7841657
7848824
7873877
7953654
8011322
8011324
8013342
8064697
8129927
8141806
8203509
8215036
8268655
8276243
8297798
8353175
8358865
8374208
8390853
8395365
8398121
8398122
8402901
8402902
8452930
8486363
8530040
8536631
8564845
8595902
8636401
8661704
8706788
8710922
8742817
8743987
8813730
8853393
8873975
8958230
8981482
8995241
9021140
9051257
9067931
9135074
9169087
9259189
9275078
9281335
9294108
9324049
9348175
9354418
9447922
9473344
9510969
9551868
9615234
9630227
9671658
9685224
9731712
9819431
9889200
9925986
9927325
9988218
9989803
10027293
10037786
10077676
10087299
10092114
10205143
10213459
10218945
10226789
10322637
10349636
10359843
10377413
10385438
10423295
10459853
10465256
10467223
10467238
10502456
10503715
10537134
10537147
10544175
10544181
10611509
10622417
10673454
10706738
10712011
10749124
10751206
10791764
10875273
10922068
10926090
10926756
10942631
10954733
11033447
11042159
11063034
11069951
11076861
11087842
11108252
11133160
11134182
11159375
11217851
11231069
11250928
11334415
11376627
11389552
11409899
11438121
11459808
11472836
11517160
11517161
11564695
11567053
11606442
11735249
11751931
11756339
11760848
11846487
11867450
11897712
11918215
11927606
11934830
11956170
11973363
11994404
12020946
12021187
12039068
12101187
12112378
12122065
12135605
12163409
12175647
12190109
12202493
12208536
12211426
12215457
12235108
12397630
12399417
12407098
12412805
12415260
12431371
12466851
12477932
12482503
12504277
12511852
12538586
12574418
12586770
12591604
12592384
12626499
12644296
12697712
12700634
12734191
12771153
12786966
12805218
12815703
12850279
12858577
12865332
12865502
12874218
12900931
12904469
12907608
12933651
12959969
12960002
14514630
14534298
14559999
14566968
14568566
14583653
14585811
14610273
14642651
14673173
14681479
14681493
14702113
14726438
14741342
14741375
14752777
14765976
14993222
15028529
15044591
15056934
15059953
15060147
15062551
15090033
15117747
15125842
15139287
15192078
15210967
15242989
15247258
15247278
15254679
15308683
15316031
15322112
15333746
15351513
15389530
15448167
15472070
15489334
15537892
15542029
15550386
15561943
15579642
15580568
15582152
15585589
15597051
15604210
15611085
15653674
15657392
15694135
15703188
15707970
15718052
15721138
15752742
15760467
15761030
15761851
15769793
15798188
15840636
15843550
15844178
15930167
15937872
15964559
15967802
15970625
16002520
16099410
16123158
16141072
16141073
16141355
16168397
16169744
16183214
16185287
16257281
16275752
16294267
16297183
16311053
16338473
16400188
16420467
16427371
16439513
16452166
16461770
16495447
16554406
16574995
16598383
16602821
16644298
16648296
16675518
16691571
16709615
16731792
16783635
16857753
16869890
16890611
16893423
16901968
16905376
16912042
16914747
16935839
16939393
16959842
17001448
17008389
17077188
17130467
17138659
17164836
17169417
17211878
17229811
17234973
17264161
17275062
17332154
17334835
17376816
17388800
17443310
17488198
17495119
17510462
17517131
17519362
17525368
17531350
17535874
17561816
17569567
17590360
17596519
17635806
17636024
17644814
17653731
17688880
17693256
17717052
17848918
17884945
17895382
17904393
17918153
17921143
17961524
17964260
17971008
17973971
17975158
17991321
18040896
18086533
18199585
18212051
18213577
18270299
18270301
18274454
18276757
18287559
18321982
18338791
18361482
18367086
18367630
18392786
18393560
18445879
18450962
18451161
18466921
18483250
18495459
18497448
18502759
18550407
18583416
18583422
18648544
18651291
18676006
18678349
18682576
18706390
18717815
18718566
18722179
18729805
18757483
18772608
18793116
18795097
18801449
18812464
18812566
18827067
18831980
18841528
18938165
18948844
18952711
18977203
19033454
19064939
19092722
19098425
19132750
19164599
19208758
19208815
19232325
19246485
19246539
19257833
19359179
19363488
19375133
19406747
19415693
19460757
19473988
19497975
19513790
19578119
19595440
19603014
19603528
19605562
19608653
19619004
19627267
19657059
19665542
19679072
19696100
19703413
19712103
19713527
19723289
19731048
19744960
19751099
19759331
19819949
19821771
19824875
19834007
19884348
19888832
19920132
19933931
19937471
20007461
20007694
20008164
20032059
20042609
20045394
20045424
20048072
20056750
20067789
20084055
20097678
20098959
20103605
20111592
20133429
20145127
20162728
20179101
20198387
20200935
20203337
20206269
20207740
20228261
20304951
20307585
20351102
20359476
20360006
20363874
20382057
20409609
20412061
20487000
20506299
20508974
20596079
20671230
20678571
20685873
20722057
20731752
20734455
20735370
20798132
20829391
20830296
20836088
20889618
20926579
20928887
20979700
21106878
21127009
21147879
21156168
21187969
21192914
21239445
21245137
21281823
21284987
21287577
21325354
21330367
21335474
21354104
21372140
21379568
21386911
21404709
21406500
21413931
21418509
21418519
21429986
21441569
21445249
21447628
21454706
21461751
21462085
21471200
21486933
21520275
21524689
21527499
21593196
21618536
21621517
21628395
21763763
21795402
21795542
21799924
21802327
21858045
21862615
21867536
21872589
21878662
22005015
22006370
22021391
22023218
22028467
22033112
22035642
22049075
22125316
22135164
22139534
22159122
22160926
22164296
22167021
22182837
22197584
22210772
22228770
22230888
22308338
22323595
22326222
22342795
22357625
22363814
22371576
22402333
22419082
22434656
22461702
22467218
22482728
22513648
22559791
22560297
22563064
22566614
22653556
22653858
22682244
22688304
22729283
22750159
22761311
22767591
22791713
22797923
22808460
22810305
22843623
22873171
22877754
22878411
22927645
22932784
22936724
22967900
23031221
23032105
23039828
23054195
23102937
23103586
23135700
23183171
23209448
23213481
23251442
23291913
23322734
23340251
23345244
23359486
23404854
23406214
23407451
23416526
23456957
23485865
23485973
23499423
23525041
23555635
23583271
23584732
23612968
23620587
23627689
23631823
23649836
23657003
23668415
23669345
23686362
23689346
23695213
23696648
23703152
23715728
23741292
23818291
23833202
23880139
23906066
23960076
23980075
23980167
24064357
24103846
24154525
24279352
24326453
24429066
24469459
24517230
24552398
24569593
24582811
24597654
24606898

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001974  blood vessel remodeling
GO:0048754  branching morphogenesis of a tube
GO:0048468  cell development
GO:0050650  chondroitin sulfate proteoglycan biosynthetic process
GO:0031017  exocrine pancreas development
GO:0010001  glial cell differentiation
GO:0048839  inner ear development
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0048286  lung alveolus development
GO:0030324  lung development
GO:0060463  lung lobe morphogenesis
GO:0060426  lung vasculature development
GO:0030879  mammary gland development
GO:0007613  memory
GO:0035264  multicellular organism growth
GO:0014896  muscle hypertrophy
GO:0045445  myoblast differentiation
GO:0051450  myoblast proliferation
GO:0014904  myotube cell development
GO:0060766  negative regulation of androgen receptor signaling pathway
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0008285  negative regulation of cell proliferation
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0090201  negative regulation of release of cytochrome c from mitochondria
GO:0034392  negative regulation of smooth muscle cell apoptosis
GO:0007399  nervous system development
GO:0048015  phosphoinositide-mediated signaling
GO:0042104  positive regulation of activated T cell proliferation
GO:0070886  positive regulation of calcineurin-NFAT signaling pathway
GO:0010613  positive regulation of cardiac muscle hypertrophy
GO:0030307  positive regulation of cell growth
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0045600  positive regulation of fat cell differentiation
GO:0048146  positive regulation of fibroblast proliferation
GO:0046326  positive regulation of glucose import
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0021940  positive regulation of granule cell precursor proliferation
GO:0043568  positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0045669  positive regulation of osteoblast differentiation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0046579  positive regulation of Ras protein signal transduction
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0090031  positive regulation of steroid hormone biosynthetic process
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0060527  prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060740  prostate gland epithelium morphogenesis
GO:0060736  prostate gland growth
GO:0060741  prostate gland stromal morphogenesis
GO:0030166  proteoglycan biosynthetic process
GO:0051924  regulation of calcium ion transport
GO:0042127  regulation of cell proliferation
GO:0032878  regulation of establishment or maintenance of cell polarity
GO:0001932  regulation of protein amino acid phosphorylation
GO:0051246  regulation of protein metabolic process
GO:0033143  regulation of steroid hormone receptor signaling pathway
GO:0006417  regulation of translation
GO:0014834  satellite cell maintenance involved in skeletal muscle regeneration
GO:0060509  Type I pneumocyte differentiation
GO:0060510  Type II pneumocyte differentiation
GO:0030104  water homeostasis

Cellular Component

GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005614  interstitial matrix

Molecular Function

GO:0008083  growth factor activity
GO:0005179  hormone activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005178  integrin binding
GO:0005515  protein binding
GO:0043539  protein serine/threonine kinase activator activity
GO:0005496  steroid binding