interleukin 6

詳細情報を見る

同義遺伝子名

IL-6, Il-6, Interleukin-6 precursor, Interleukin HP-1, interleukin 6, B-cell hybridoma growth factor, Il6

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:36.50 小脳:18.40 脳幹:31.80 脳梁:- 松果体:- 末梢神経:38.20 脊柱:- 網膜:- 目:22.80 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:3.52 小脳:3.65 脳幹:- 脳梁:- 松果体:- 末梢神経:3.74 脊柱:3.60 網膜:3.61 目:3.92 動脈:- 静脈:4.08 リンパ節:3.69 末梢血:- 脾臓:3.85 胸腺:- 骨髄:3.96 脂肪:3.49 骨:4.12 皮膚:3.80
CAGE 大脳:0 小脳:- 脳幹:0.14 脳梁:- 松果体:- 末梢神経:- 脊柱:0.17 網膜:- 目:- 動脈:0 静脈:- リンパ節:1.78 末梢血:- 脾臓:0.16 胸腺:0 骨髄:- 脂肪:- 骨:0 皮膚:0.15
RNA-seq nodata
EST 子宮:- 胎盤:13.80 前立腺:- 卵巣:- 精巣:14.80 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:3.41 胎盤:3.61 前立腺:3.70 卵巣:3.65 精巣:3.68 心臓:3.79 骨格筋:3.69 食道:- 胃:3.59 腸:3.55 結腸:- 肝臓:3.73 肺:3.94 膀胱:3.60 腎臓:3.47 下垂体:3.65 甲状腺:- 副腎:3.60 膵臓:3.80 乳腺:3.58 唾液腺:4.06
CAGE 子宮:0.31 胎盤:0.33 前立腺:0 卵巣:0.13 精巣:0 心臓:- 骨格筋:- 食道:- 胃:0 腸:0 結腸:0     肝臓:0    肺:0 膀胱:0 腎臓:- 下垂体:0 甲状腺:- 副腎:0.14 膵臓:0 乳腺:0 唾液腺:-
RNA-seq nodata

IDs

Refseq ID NM_031168
Gene ID 16193
Unigene ID Mm.101909
Probe set ID 1450297_at  [Mouse430_2]
Ensembl ID ENSMUSG00000025746

オーソログ対応遺伝子

ヒト[1]  NM_000600
ラット [0]  

染色体

-

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1312474
1318227
1324224
1350248
1371079
1373998
1375756
1382446
1402392
1472283
1552482
1577194
1587308
1601170
1611993
1628813
1628826
1649220
1729694
1794049
1794058
1851139
1889804
1889815
2106569
2243807
2302197
2466396
2563387
2565278
2575221
2592764
2798426
2948184
2965020
3262059
3262872
3263439
3264160
7490100
7507352
7508917
7513199
7513204
7515712
7522168
7524893
7536685
7538528
7567467
7590746
7599173
7670492
7719983
7720571
7750122
7759110
7768607
7769130
7780034
7790819
7826951
7850809
7851897
7867561
7890367
7895162
7919654
7919658
7930875
7931061
7953712
7959747
7959868
7964164
7972007
7974717
8043507
8043948
8043949
8050491
8054487
8081873
8100556
8127368
8131749
8138038
8148154
8160012
8177505
8207122
8283046
8307620
8313907
8376770
8418070
8464030
8499659
8521822
8536793
8551238
8575820
8613694
8631753
8649829
8666800
8666893
8670868
8675203
8676061
8676083
8698502
8703029
8757508
8757858
8770556
8836549
8879230
8910279
8911153
8920166
8940342
8960823
9000479
9000540
9034153
9039941
9058758
9069127
9075932
9084435
9165025
9168824
9169772
9169855
9227345
9237710
9240457
9277378
9278335
9281358
9284811
9284817
9307269
9344502
9351462
9353074
9359411
9379832
9403069
9417815
9430546
9435302
9462869
9463396
9466312
9493504
9566762
9603480
9605877
9637508
9645618
9653168
9659221
9675420
9688988
9693973
9708822
9730900
9769156
9780277
9806851
9815267
9839821
9850165
9854025
9862349
9862671
9875345
9892616
9916891
9918916
9933112
9950766
10028917
10215902
10229817
10341234
10349636
10383128
10383613
10397473
10415153
10438933
10447717
10452974
10465257
10482564
10496318
10521784
10528216
10534116
10549626
10566878
10568881
10613740
10623431
10648128
10651996
10684643
10698075
10708451
10712626
10733552
10793074
10799601
10843805
10845903
10861297
10899153
10922080
10943842
10945466
10979125
11006436
11016935
11018077
11034416
11034996
11035735
11042159
11045959
11073809
11076861
11091275
11099471
11106580
11114976
11120777
11180114
11182244
11208530
11217851
11241200
11275690
11277977
11369703
11395027
11416016
11441071
11441074
11477542
11494166
11500099
11507020
11520454
11536174
11553589
11602623
11698278
11710994
11770048
11781184
11781288
11781360
11784794
11786910
11791174
11801681
11803046
11805288
11812493
11829488
11847480
11867592
11869683
11883745
11884027
11884029
11884396
11886848
11894098
11895333
11923871
11994291
12054913
12060750
12070012
12077263
12093872
12097416
12126646
12133972
12150983
12151646
12161103
12171912
12177065
12207010
12209330
12219085
12223557
12358740
12370360
12393639
12438448
12446574
12456808
12466851
12477932
12496437
12505667
12507769
12509437
12519742
12532024
12533608
12538435
12557750
12560330
12594267
12643284
12648490
12665506
12668153
12676746
12679717
12697697
12705907
12707321
12754505
12754507
12759566
12773301
12773503
12775331
12781987
12829028
12842862
12850812
12855817
12917264
12925700
12939594
12946594
12952969
12957371
12957791
12958147
12960349
12964032
14500666
14568951
14573621
14578297
14583241
14597766
14632648
14634061
14635056
14645573
14659593
14691481
14699015
14701687
14707102
14741447
14755335
14760941
14764608
14764707
14767066
14966572
14976041
14985352
14988384
14999682
15001458
15044588
15064729
15099921
15100312
15124018
15128857
15155665
15159136
15162832
15187118
15188379
15191552
15191885
15192150
15195698
15219849
15221959
15240714
15241416
15254764
15265638
15271886
15289466
15292196
15313196
15314695
15315756
15339938
15356132
15358102
15358232
15364614
15367390
15467358
15475383
15501797
15501801
15514851
15516495
15519344
15520045
15546395
15557373
15558055
15558059
15570035
15581736
15581737
15585847
15588510
15588696
15613028
15616592
15639639
15647834
15664785
15668925
15681696
15684062
15688401
15692051
15717324
15728480
15743795
15761498
15763341
15763541
15800492
15802498
15814701
15825075
15826936
15831701
15845478
15845623
15862160
15863613
15880761
15899942
15905327
15905495
15905628
15908405
15910760
15940362
15947070
15956054
15976028
15989949
16022585
16023831
16026997
16040151
16046706
16052598
16081806
16085472
16095565
16129814
16141072
16141073
16141396
16143138
16192425
16236719
16254126
16275384
16284237
16285960
16291589
16293680
16310049
16318580
16323703
16365445
16388483
16397521
16418171
16423921
16455769
16466693
16489506
16493033
16493060
16513824
16554296
16567518
16571868
16581004
16602821
16611629
16651528
16670325
16670770
16677721
16707807
16710471
16717113
16718380
16763563
16785562
16791879
16809219
16815711
16843000
16844679
16844762
16894357
16914507
16925466
16939807
16943298
16981137
16990136
16996249
17003332
17010015
17050710
17056539
17056560
17065508
17077645
17082315
17082570
17086187
17089190
17101148
17109471
17109863
17114246
17114459
17133451
17141199
17142776
17144903
17150369
17151194
17178916
17182564
17182684
17187052
17190745
17192276
17213200
17220181
17227914
17229673
17236833
17255200
17255318
17256754
17272771
17277142
17314284
17322283
17324158
17340223
17383969
17391979
17400600
17404849
17409491
17412346
17433708
17438336
17467814
17475827
17476359
17481608
17487773
17493959
17506816
17510220
17513714
17513718
17525280
17531241
17532082
17546038
17557918
17573464
17575466
17581537
17581588
17581589
17591434
17591976
17599806
17601518
17606866
17609432
17615159
17615358
17639077
17640882
17641006
17646407
17669273
17674319
17675251
17678624
17683066
17688975
17693256
17697009
17712049
17716906
17716980
17724375
17724432
17728706
17823890
17825250
17885684
17911113
17919941
17919942
17920057
17921078
17932568
17933551
17947654
17961512
17962626
17967442
17973207
17975158
17981790
17989316
17994024
18000830
18040755
18042545
18056837
18056981
18059272
18059318
18070744
18073505
18083102
18085494
18089828
18096870
18097045
18097062
18156493
18165179
18177723
18192501
18210237
18217411
18233961
18236210
18261938
18264109
18287966
18296709
18311788
18313231
18322171
18322221
18322234
18337485
18353866
18359888
18362111
18365876
18367337
18372239
18378582
18389078
18390697
18406623
18423196
18426864
18426983
18431520
18434191
18437347
18450421
18451609
18453602
18454155
18458097
18471413
18480244
18490655
18490708
18490717
18492848
18504307
18516037
18516038
18522647
18523259
18524936
18535177
18535667
18535671
18546146
18559975
18565597
18566365
18566419
18566435
18573898
18581322
18586382
18586856
18596724
18599325
18606643
18606667
18606685
18606688
18607538
18617512
18618311
18619543
18619964
18621544
18636046
18641356
18641358
18641637
18665050
18683503
18710929
18714032
18719127
18722365
18763316
18776134
18778200
18779348
18782771
18792410
18796617
18799889
18803240
18803824
18805458
18819004
18831917
18832718
18834949
18835196
18848474
18927263
18929410
18942706
18945671
18948191
18950689
18955501
18973601
18991854
19006694
19020307
19029903
19050105
19071214
19074180
19084112
19084435
19091984
19097069
19109195
19109197
19110542
19122641
19136564
19139170
19139201
19168699
19168721
19173740
19177625
19181387
19185844
19185845
19204109
19204324
19224206
19224760
19228664
19234091
19234175
19243473
19258035
19258660
19265263
19277492
19284588
19289507
19299019
19299453
19307557
19327545
19329554
19342884
19357252
19363165
19378383
19404405
19414775
19420002
19426550
19436757
19443690
19460787
19461124
19470750
19471100
19477016
19490366
19491392
19494314
19494331
19496170
19500387
19524707
19538487
19541630
19542449
19553536
19564350
19564351
19566825
19578789
19581928
19587013
19587788
19589542
19592651
19597000
19602992
19608614
19635913
19643985
19644888
19648929
19666510
19668221
19681796
19701194
19712053
19734905
19735291
19745193
19750482
19758168
19767842
19773091
19782405
19786067
19786548
19801514
19806220
19808254
19808647
19812355
19815878
19821485
19822443
19825975
19833167
19834028
19879324
19890042
19902173
19902429
19907005
19918056
19920349
19926874
19936233
19950212
19955044
19955433
19965598
20002448
20007527
20007530
20008137
20012010
20016056
20018623
20031163
20035621
20042455
20042579
20042582
20042666
20052801
20056085
20056108
20060814
20082310
20083652
20083654
20083665
20083667
20089698
20089716
20093401
20101093
20123961
20130114
20130211
20138782
20141834
20151299
20185820
20189822
20212509
20221584
20221673
20350813
20351305
20354107
20360400
20368703
20372827
20381429
20386569
20394076
20401626
20406809
20411234
20415720
20458283
20465571
20466823
20479237
20483735
20483921
20489168
20519643
20554759
20564347
20578264
20584975
20601599
20610570
20610641
20620996
20652679
20653471
20671912
20675594
20682912
20690183
20691261
20697374
20697689
20732383
20733031
20733201
20738764
20811044
20816090
20826731
20832339
20849821
20864798
20870936
20870942
20876350
20876575
20889504
20929542
20931558
20934884
20945380
20974218
20974942
20980632
21041732
21041952
21048959
21054849
21055089
21083649
21093318
21098042
21098094
21106853
21115736
21127061
21129806
21131162
21131172
21145762
21145830
21148317
21148472
21148800
21151872
21169556
21187450
21195166
21195346
21198751
21220456
21224226
21228224
21248260
21256159
21257958
21264293
21266900
21267068
21270264
21285312
21289639
21297079
21307291
21321532
21326608
21332025
21334079
21352507
21354910
21371434
21393247
21394214
21398615
21418148
21419662
21422245
21423809
21430223
21439396
21439958
21449942
21454528
21459325
21474672
21478097
21478151
21481788
21494547
21502744
21518876
21519345
21529825
21536657
21537082
21551364
21564350
21586125
21593380
21595886
21595956
21606248
21617699
21622681
21632071
21633411
21640704
21642586
21664343
21690252
21690373
21697358
21703414
21705340
21710691
21725996
21736830
21742851
21771795
21799119
21799929
21802163
21825016
21835648
21865055
21880664
21881585
21890220
21898505
21918192
21930594
21940443
21944889
21948081
21960530
21976681
21983868
21984337
21986000
21990364
21991887
21996012
21999714
22000153
22025555
22031852
22034510
22037645
22044313
22044916
22050227
22054060
22062222
22068875
22075248
22081022
22094259
22101131
22102721
22128916
22129063
22130158
22135163
22154464
22156492
22179317
22184721
22205605
22212899
22231518
22249203
22252554
22262690
22264787
22268122
22278939
22281010
22284955
22291094
22294047
22304915
22316079
22319003
22326556
22328203
22342156
22344519
22351769
22364742
22405769
22424785
22467660
22469696
22489868
22490805
22492561
22519587
22533966
22536401
22547695
22560297
22574112
22596222
22609298
22611157
22623033
22633286
22634167
22648519
22653620
22660275
22666517
22669242
22669509
22673618
22675201
22679491
22682244
22684844
22706344
22715999
22716658
22745377
22753938
22761278
22764777
22772723
22777957
22791336
22798669
22819759
22825686
22829762
22836752
22837198
22837383
22844518
22848390
22848425
22854263
22855834
22884451
22904305
22919324
22921334
22932797
22940293
22966985
22980031
22980983
22985907
22995520
23010503
23022409
23027872
23037942
23045607
23046379
23064268
23085146
23114963
23134512
23136556
23145171
23169140
23177319
23184091
23184935
23184950
23200827
23201430
23209286
23213461
23213481
23221344
23225885
23230288
23234871
23240005
23241882
23254193
23255360
23267024
23272241
23277488
23281399
23297399
23319739
23321674
23322593
23322734
23348396
23359591
23364351
23377201
23408169
23414303
23416685
23426178
23435784
23444404
23445618
23447690
23449935
23460747
23462222
23484075
23489698
23499905
23504518
23509362
23509933
23517603
23520506
23520517
23520526
23525184
23527226
23528820
23534555
23536772
23537804
23542345
23564454
23577207
23589622
23593346
23613464
23630359
23636453
23637926
23643536
23661644
23664832
23673000
23685554
23690222
23696660
23732361
23761105
23763486
23766515
23772033
23776175
23788765
23791647
23791889
23797667
23799152
23806095
23815102
23817085
23822633
23825949
23827828
23830919
23836031
23836059
23840908
23843519
23846700
23850243
23857287
23857584
23867565
23877071
23883516
23892723
23906629
23922826
23944357
23948300
23948778
23954701
23966393
23988623
23990363
23996485
24012418
24015235
24028747
24051241
24052031
24053646
24067382
24078687
24088994
24097820
24120137
24121404
24140628
24144034
24166778
24185641
24209760
24231354
24244024
24248597
24260500
24312665
24337386
24337738
24352037
24357729
24362892
24376270
24379058
24381131
24412616
24421314
24431229
24442436
24478088
24517026
24532586
24550390
24605680
24647961
24658075
24659688
24681566
24738290

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006953  acute-phase response
GO:0060445  branching involved in salivary gland morphogenesis
GO:0016049  cell growth
GO:0045454  cell redox homeostasis
GO:0070301  cellular response to hydrogen peroxide
GO:0019221  cytokine-mediated signaling pathway
GO:0042832  defense response to protozoan
GO:0051607  defense response to virus
GO:0031018  endocrine pancreas development
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0070091  glucagon secretion
GO:0002384  hepatic immune response
GO:0006955  immune response
GO:0006954  inflammatory response
GO:0070102  interleukin-6-mediated signaling pathway
GO:0046716  muscle homeostasis
GO:0043066  negative regulation of apoptosis
GO:0043154  negative regulation of caspase activity
GO:0008285  negative regulation of cell proliferation
GO:0045079  negative regulation of chemokine biosynthetic process
GO:0032966  negative regulation of collagen biosynthetic process
GO:0050710  negative regulation of cytokine secretion
GO:0045721  negative regulation of gluconeogenesis
GO:0046888  negative regulation of hormone secretion
GO:0048635  negative regulation of muscle organ development
GO:0006469  negative regulation of protein kinase activity
GO:0031175  neuron projection development
GO:0001781  neutrophil apoptosis
GO:0002675  positive regulation of acute inflammatory response
GO:0050871  positive regulation of B cell activation
GO:0008284  positive regulation of cell proliferation
GO:0032722  positive regulation of chemokine production
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0010628  positive regulation of gene expression
GO:0051024  positive regulation of immunoglobulin secretion
GO:0032755  positive regulation of interleukin-6 production
GO:0046427  positive regulation of JAK-STAT cascade
GO:0043410  positive regulation of MAPKKK cascade
GO:0045666  positive regulation of neuron differentiation
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0042102  positive regulation of T cell proliferation
GO:0045630  positive regulation of T-helper 2 cell differentiation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045727  positive regulation of translation
GO:0051971  positive regulation of transmission of nerve impulse
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042981  regulation of apoptosis
GO:0042127  regulation of cell proliferation
GO:0008360  regulation of cell shape
GO:0045188  regulation of circadian sleep/wake cycle, non-REM sleep
GO:0010574  regulation of vascular endothelial growth factor production
GO:0051384  response to glucocorticoid stimulus
GO:0009611  response to wounding
GO:0042110  T cell activation

Cellular Component

GO:0009897  external side of plasma membrane
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005896  interleukin-6 receptor complex

Molecular Function

GO:0005125  cytokine activity
GO:0008083  growth factor activity
GO:0005138  interleukin-6 receptor binding
GO:0005515  protein binding
GO:0005102  receptor binding