Janus kinase 2

詳細情報を見る

同義遺伝子名

Fd17, Jak2, C81284, JAK-2, AI504024, Janus kinase 2, Tyrosine-protein kinase JAK2

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:38.20

小脳:18.40

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:32.10

目:91.20

動脈:-

静脈:-

リンパ節:54

末梢血:158.10

脾臓:79

胸腺:128.40

骨髄:38.50

脂肪:-

骨:25

皮膚:23.80

GeneChip

大脳:7.45

小脳:7.02

脳幹:-

脳梁:-

松果体:-

末梢神経:6.64

脊柱:7.19

網膜:6.28

目:6.33

動脈:-

静脈:8.21

リンパ節:9.20

末梢血:-

脾臓:8.82

胸腺:-

骨髄:8.91

脂肪:7.42

骨:8.97

皮膚:7.16

CAGE

大脳:3.02

小脳:-

脳幹:3.10

脳梁:-

松果体:-

末梢神経:-

脊柱:3.31

網膜:-

目:-

動脈:3.26

静脈:-

リンパ節:4.25

末梢血:-

脾臓:4.10

胸腺:3.93

骨髄:-

脂肪:-

骨:4.05

皮膚:3.37

RNA-seq

大脳:1.65

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:27.60

前立腺:61.80

卵巣:137.90

精巣:7.40

心臓:-

骨格筋:35.50

食道:-

胃:-

腸:-

結腸:17.60

肝臓:-

肺:40.20

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:19.60

唾液腺:54

GeneChip

子宮:9.53

胎盤:8.17

前立腺:7.11

卵巣:8.06

精巣:5.79

心臓:6.85

骨格筋:8.46

食道:-

胃:7.61

腸:8.33

結腸:-

肝臓:6.81

肺:7.75

膀胱:8.08

腎臓:6.74

下垂体:7.34

甲状腺:-

副腎:5.95

膵臓:6.44

乳腺:7.79

唾液腺:5.20

CAGE

子宮:4.88

胎盤:3.40

前立腺:3.02

卵巣:3.60

精巣:1.34

心臓:-

骨格筋:-

食道:-

胃:3.29

腸:4.54

結腸:4.44

肝臓:3.09

肺:3.81

膀胱:3.49

腎臓:-

下垂体:3.21

甲状腺:-

副腎:3.07

膵臓:3.04

乳腺:3.25

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:3.38

食道:-

胃:-

腸:-

結腸:-

肝臓:2.21

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_001048177
Gene ID	16452
Unigene ID	Mm.275839
Probe set ID	1421065_at [Mouse430_2]
Ensembl ID	ENSMUSG00000024789

オーソログ対応遺伝子

ヒト[2]	NM_004972
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

遺伝子オントロジー (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0042977	activation of JAK2 kinase activity
GO:0000186	activation of MAPKK activity
GO:0031103	axon regeneration
GO:0030154	cell differentiation
GO:0016568	chromatin modification
GO:0019221	cytokine-mediated signaling pathway
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0030218	erythrocyte differentiation
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0060396	growth hormone receptor signaling pathway
GO:0009755	hormone-mediated signaling pathway
GO:0034050	host programmed cell death induced by symbiont
GO:0008631	induction of apoptosis by oxidative stress
GO:0045087	innate immune response
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0007259	JAK-STAT cascade
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0031959	mineralocorticoid receptor signaling pathway
GO:0030099	myeloid cell differentiation
GO:0043066	negative regulation of apoptosis
GO:0008285	negative regulation of cell proliferation
GO:0022408	negative regulation of cell-cell adhesion
GO:0043392	negative regulation of DNA binding
GO:0045822	negative regulation of heart contraction
GO:0043524	negative regulation of neuron apoptosis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0016310	phosphorylation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptosis
GO:0050867	positive regulation of cell activation
GO:0045597	positive regulation of cell differentiation
GO:0030335	positive regulation of cell migration
GO:0008284	positive regulation of cell proliferation
GO:0010811	positive regulation of cell-substrate adhesion
GO:0043388	positive regulation of DNA binding
GO:0060399	positive regulation of growth hormone receptor signaling pathway
GO:0050729	positive regulation of inflammatory response
GO:0032024	positive regulation of insulin secretion
GO:0032731	positive regulation of interleukin-1 beta production
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0051091	positive regulation of transcription factor activity
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0007243	protein kinase cascade
GO:0050727	regulation of inflammatory response
GO:0046677	response to antibiotic
GO:0033194	response to hydroperoxide
GO:0070671	response to interleukin-12
GO:0032496	response to lipopolysaccharide
GO:0006979	response to oxidative stress
GO:0034612	response to tumor necrosis factor
GO:0007165	signal transduction
GO:0007262	STAT protein nuclear translocation
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0042508	tyrosine phosphorylation of Stat1 protein
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042506	tyrosine phosphorylation of Stat5 protein

Cellular Component

GO:0005901	caveola
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0016020	membrane
GO:0045121	membrane raft
GO:0016363	nuclear matrix
GO:0005634	nucleus

Molecular Function

GO:0033130	acetylcholine receptor binding
GO:0005524	ATP binding
GO:0005131	growth hormone receptor binding
GO:0020037	heme binding
GO:0042393	histone binding
GO:0043560	insulin receptor substrate binding
GO:0005143	interleukin-12 receptor binding
GO:0016301	kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0000166	nucleotide binding
GO:0051428	peptide hormone receptor binding
GO:0043548	phosphoinositide 3-kinase binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004713	protein tyrosine kinase activity
GO:0005102	receptor binding
GO:0042169	SH2 domain binding
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031702	type 1 angiotensin receptor binding

IPR019749	Band 4.1 domain
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020693	Tyrosine-protein kinase, non-receptor Jak2
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Janus kinase 2

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function