Janus kinase 2

詳細情報を見る

同義遺伝子名

Fd17, Jak2, C81284, JAK-2, AI504024, Janus kinase 2, Tyrosine-protein kinase JAK2

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:38.20 小脳:18.40 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:32.10 目:91.20 動脈:- 静脈:- リンパ節:54 末梢血:158.10 脾臓:79 胸腺:128.40 骨髄:38.50 脂肪:- 骨:25 皮膚:23.80
GeneChip 大脳:8.53 小脳:8.20 脳幹:- 脳梁:- 松果体:- 末梢神経:7.69 脊柱:7.58 網膜:8.73 目:8.81 動脈:- 静脈:9.15 リンパ節:10.23 末梢血:- 脾臓:9.92 胸腺:- 骨髄:9.83 脂肪:8.38 骨:9.90 皮膚:8.81
CAGE 大脳:3.02 小脳:- 脳幹:3.10 脳梁:- 松果体:- 末梢神経:- 脊柱:3.31 網膜:- 目:- 動脈:3.26 静脈:- リンパ節:4.25 末梢血:- 脾臓:4.10 胸腺:3.93 骨髄:- 脂肪:- 骨:4.05 皮膚:3.37
RNA-seq 大脳:1.65 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:27.60 前立腺:61.80 卵巣:137.90 精巣:7.40 心臓:- 骨格筋:35.50 食道:- 胃:- 腸:- 結腸:17.60     肝臓:-        肺:40.20    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:19.60 唾液腺:54
GeneChip 子宮:10.42 胎盤:8.48 前立腺:8.28 卵巣:8.99 精巣:5.83 心臓:7.95 骨格筋:8.73 食道:- 胃:8.79 腸:9.51 結腸:- 肝臓:7.57 肺:8.79 膀胱:8.94 腎臓:8.18 下垂体:8.45 甲状腺:- 副腎:8.56 膵臓:7.61 乳腺:8.78 唾液腺:8.40
CAGE 子宮:4.88 胎盤:3.40 前立腺:3.02 卵巣:3.60 精巣:1.34 心臓:- 骨格筋:- 食道:- 胃:3.29 腸:4.54 結腸:4.44     肝臓:3.09    肺:3.81 膀胱:3.49 腎臓:- 下垂体:3.21 甲状腺:- 副腎:3.07 膵臓:3.04 乳腺:3.25 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:3.38 食道:- 胃:- 腸:- 結腸:-     肝臓:2.21        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_001048177
Gene ID 16452
Unigene ID Mm.275839
Probe set ID 1421066_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024789

オーソログ対応遺伝子

ヒト[2]  NM_004972
ラット [0]  

染色体

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遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1281307
1581631
1620548
1848670
2466296
2482828
7499280
7499845
7534285
7535773
7539296
7542761
7544789
7607555
7613027
7657660
7775438
7782332
7889566
7893599
8022486
8034026
8063772
8208550
8272873
8343951
8378315
8593242
8611693
8662243
8889548
8918879
8923468
8934548
8943354
9038232
9119818
9154835
9202126
9247268
9342212
9343427
9363897
9446644
9548458
9573010
9590173
9590174
9624169
9638363
9869640
9889194
10200816
10349636
10374907
10526570
10600756
10679268
10725249
10757801
10781830
10842184
10842319
10872802
10872831
10918061
10922068
10931824
11042159
11076861
11114734
11217851
11360203
11489994
11536325
11679576
11779507
11821424
11875116
11881154
11944994
11970898
11980901
12007403
12040017
12106016
12147240
12351625
12370296
12388746
12393587
12393730
12426001
12456798
12466851
12477932
12488507
12551917
12594853
12686512
12691918
12704203
12748279
12920237
12921784
12952963
14522994
14525952
14610273
14729671
14759523
14996842
14998905
15007095
15012602
15016718
15102475
15121872
15143188
15156153
15169911
15292206
15354294
15358195
15475610
15522878
15640156
15659653
15677447
15688008
15705783
15746188
15790774
15793561
15815685
15899943
15923602
15988755
16025117
16084495
16141072
16141073
16230418
16254141
16280321
16365288
16478879
16563502
16602821
16670266
16705159
16705160
16804112
16824542
16847321
16887119
16914724
16959875
17024180
17078929
17128263
17183644
17290288
17317861
17404288
17519353
17543594
17547694
17550976
17726017
17728251
17761766
17823504
17981124
18033315
18079966
18158285
18160720
18216297
18216868
18239084
18326042
18424709
18430728
18464116
18480424
18485152
18499741
18515659
18636744
18653779
18682290
18692472
18718905
18835816
18854310
19075017
19103753
19234114
19250698
19261614
19281795
19287004
19289461
19293402
19318353
19341767
19361784
19494234
19500160
19508864
19538478
19571317
19638583
19638629
19789710
19835845
19884384
19887489
19888448
20028972
20068132
20197548
20231889
20304997
20360640
20363735
20372968
20425335
20440769
20472827
20489053
20541703
20568122
20592027
20639901
20663870
20669261
20696946
20724918
20940045
20974963
20979137
21102457
21149549
21151131
21209203
21255641
21267068
21268070
21347402
21354995
21362419
21364286
21393331
21420414
21423214
21557940
21572044
21633967
21726629
21802163
21808064
21885612
21941370
22051730
22065597
22124464
22131881
22144185
22234689
22275361
22281400
22286129
22369852
22378845
22384256
22402124
22508938
22546852
22627765
22740348
22837531
22892029
22972935
22999860
22999939
23047097
23223021
23264594
23300995
23340136
23389690
23407880
23435120
23487027
23502961
23526587
23533276
23544085
23548897
23558526
23581279
23590807
23630962
23747947
23750118
23782652
23838182
23863895
23926298
24013029
24069548
24085768
24086539
24169825
24237791
24469804
24486434
24531222
24608040
24692758

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0042977  activation of JAK2 kinase activity
GO:0000186  activation of MAPKK activity
GO:0031103  axon regeneration
GO:0030154  cell differentiation
GO:0016568  chromatin modification
GO:0019221  cytokine-mediated signaling pathway
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0030218  erythrocyte differentiation
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0060396  growth hormone receptor signaling pathway
GO:0009755  hormone-mediated signaling pathway
GO:0034050  host programmed cell death induced by symbiont
GO:0008631  induction of apoptosis by oxidative stress
GO:0045087  innate immune response
GO:0060333  interferon-gamma-mediated signaling pathway
GO:0007259  JAK-STAT cascade
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0031959  mineralocorticoid receptor signaling pathway
GO:0030099  myeloid cell differentiation
GO:0043066  negative regulation of apoptosis
GO:0008285  negative regulation of cell proliferation
GO:0022408  negative regulation of cell-cell adhesion
GO:0043392  negative regulation of DNA binding
GO:0045822  negative regulation of heart contraction
GO:0043524  negative regulation of neuron apoptosis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0016310  phosphorylation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0050867  positive regulation of cell activation
GO:0045597  positive regulation of cell differentiation
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0010811  positive regulation of cell-substrate adhesion
GO:0043388  positive regulation of DNA binding
GO:0060399  positive regulation of growth hormone receptor signaling pathway
GO:0050729  positive regulation of inflammatory response
GO:0032024  positive regulation of insulin secretion
GO:0032731  positive regulation of interleukin-1 beta production
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0032516  positive regulation of phosphoprotein phosphatase activity
GO:0033160  positive regulation of protein import into nucleus, translocation
GO:0051091  positive regulation of transcription factor activity
GO:0032760  positive regulation of tumor necrosis factor production
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523  positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0050727  regulation of inflammatory response
GO:0046677  response to antibiotic
GO:0033194  response to hydroperoxide
GO:0070671  response to interleukin-12
GO:0032496  response to lipopolysaccharide
GO:0006979  response to oxidative stress
GO:0034612  response to tumor necrosis factor
GO:0007165  signal transduction
GO:0007262  STAT protein nuclear translocation
GO:0033209  tumor necrosis factor-mediated signaling pathway
GO:0007260  tyrosine phosphorylation of STAT protein
GO:0042508  tyrosine phosphorylation of Stat1 protein
GO:0042503  tyrosine phosphorylation of Stat3 protein
GO:0042506  tyrosine phosphorylation of Stat5 protein

Cellular Component

GO:0005901  caveola
GO:0005737  cytoplasm
GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0016020  membrane
GO:0045121  membrane raft
GO:0016363  nuclear matrix
GO:0005634  nucleus

Molecular Function

GO:0033130  acetylcholine receptor binding
GO:0005524  ATP binding
GO:0005131  growth hormone receptor binding
GO:0020037  heme binding
GO:0042393  histone binding
GO:0043560  insulin receptor substrate binding
GO:0005143  interleukin-12 receptor binding
GO:0016301  kinase activity
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0000166  nucleotide binding
GO:0051428  peptide hormone receptor binding
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0008022  protein C-terminus binding
GO:0004672  protein kinase activity
GO:0019901  protein kinase binding
GO:0004713  protein tyrosine kinase activity
GO:0005102  receptor binding
GO:0042169  SH2 domain binding
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0031702  type 1 angiotensin receptor binding