leukemia inhibitory factor

同義遺伝子名

Lif, Leukemia inhibitory factor precursor, LIF, Differentiation-stimulating factor, leukemia inhibitory factor, D factor

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:-

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:95.50

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:172.80

末梢血:14.40

脾臓:237

胸腺:9.90

骨髄:-

脂肪:-

骨:25

皮膚:7.90

GeneChip

大脳:4.20

小脳:4.20

脳幹:-

脳梁:-

松果体:-

末梢神経:4.26

脊柱:4.34

網膜:4.38

目:4.71

動脈:-

静脈:4.22

リンパ節:3.84

末梢血:-

脾臓:4.16

胸腺:-

骨髄:4.32

脂肪:4.12

骨:4.12

皮膚:4.09

CAGE

大脳:0

小脳:-

脳幹:0.07

脳梁:-

松果体:-

末梢神経:-

脊柱:0

網膜:-

目:-

動脈:0.14

静脈:-

リンパ節:1.28

末梢血:-

脾臓:0

胸腺:0

骨髄:-

脂肪:-

骨:0

皮膚:0.15

RNA-seq

大脳:0.76

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:35.20

肝臓:36.20

肺:-

膀胱:-

腎臓:-

下垂体:12.90

甲状腺:-

副腎:-

膵臓:37.50

乳腺:22.90

唾液腺:-

GeneChip

子宮:4.11

胎盤:4.40

前立腺:4.07

卵巣:3.89

精巣:4.50

心臓:4.34

骨格筋:4.04

食道:-

胃:4.23

腸:4.09

結腸:-

肝臓:4.34

肺:4.01

膀胱:4.36

腎臓:4.18

下垂体:4.24

甲状腺:-

副腎:4.05

膵臓:4.58

乳腺:4.35

唾液腺:4.28

CAGE

子宮:2.94

胎盤:0.37

前立腺:0

卵巣:0

精巣:0

心臓:-

骨格筋:-

食道:-

胃:0

腸:0.23

結腸:0.23

肝臓:0

肺:0.17

膀胱:0.18

腎臓:-

下垂体:0

甲状腺:-

副腎:0.14

膵臓:0

乳腺:0.12

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:0.60

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_008501
Gene ID	16878
Unigene ID	Mm.4964
Probe set ID	1421206_at [Mouse430_2]
Ensembl ID	ENSMUSG00000034394

オーソログ対応遺伝子

ヒト[1]	NM_002309
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR009079	Four-helical cytokine-like, core
IPR003624	Leukemia inhibitory factor
IPR001581	Leukemia inhibitory factor /oncostatin

遺伝子オントロジー (GO ID)

Biological Process

GO:0048708	astrocyte differentiation
GO:0001974	blood vessel remodeling
GO:0046697	decidualization
GO:0007566	embryo implantation
GO:0006955	immune response
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0048286	lung alveolus development
GO:0030324	lung development
GO:0060463	lung lobe morphogenesis
GO:0060426	lung vasculature development
GO:0060135	maternal process involved in female pregnancy
GO:0048644	muscle organ morphogenesis
GO:0016525	negative regulation of angiogenesis
GO:0008285	negative regulation of cell proliferation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0046888	negative regulation of hormone secretion
GO:0045835	negative regulation of meiosis
GO:0048666	neuron development
GO:0031100	organ regeneration
GO:0051461	positive regulation of adrenocorticotropin secretion
GO:0048711	positive regulation of astrocyte differentiation
GO:0008284	positive regulation of cell proliferation
GO:0045651	positive regulation of macrophage differentiation
GO:0043410	positive regulation of MAPKKK cascade
GO:0010976	positive regulation of neuron projection development
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595	regulation of cell differentiation
GO:0060041	retina development in camera-type eye
GO:0060708	spongiotrophoblast differentiation
GO:0048863	stem cell differentiation
GO:0019827	stem cell maintenance
GO:0060290	transdifferentiation
GO:0060707	trophoblast giant cell differentiation
GO:0042503	tyrosine phosphorylation of Stat3 protein

Cellular Component

GO:0005737	cytoplasm
GO:0005576	extracellular region
GO:0005615	extracellular space

Molecular Function

GO:0005125	cytokine activity
GO:0008083	growth factor activity
GO:0005146	leukemia inhibitory factor receptor binding
GO:0005102	receptor binding

leukemia inhibitory factor

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function