MAD homolog 3 (Drosophila)

詳細情報を見る

同義遺伝子名

Smad 3, mMad3, Madh3, Mothers against decapentaplegic homolog 3, Smad3, MAD homolog 3 (Drosophila), Mothers against DPP homolog 3, Mad3, SMAD 3, AU022421

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:1.70 小脳:36.80 脳幹:- 脳梁:- 松果体:- 末梢神経:19.10 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:12.50 皮膚:-
GeneChip 大脳:6.15 小脳:6.10 脳幹:- 脳梁:- 松果体:- 末梢神経:5.08 脊柱:5.52 網膜:4.82 目:4.75 動脈:- 静脈:5.81 リンパ節:5.98 末梢血:- 脾臓:5.83 胸腺:- 骨髄:6.01 脂肪:5.93 骨:5.28 皮膚:5.15
CAGE 大脳:2.77 小脳:- 脳幹:1.93 脳梁:- 松果体:- 末梢神経:- 脊柱:2.35 網膜:- 目:- 動脈:2.93 静脈:- リンパ節:2.33 末梢血:- 脾臓:2.54 胸腺:2.99 骨髄:- 脂肪:- 骨:3.21 皮膚:2.82
RNA-seq 大脳:5.88 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:472.90 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:6.01 胎盤:6.71 前立腺:5.52 卵巣:6.20 精巣:5.33 心臓:5.73 骨格筋:8.54 食道:- 胃:5.68 腸:5.99 結腸:- 肝臓:5.62 肺:6.26 膀胱:6.89 腎臓:6.15 下垂体:6.22 甲状腺:- 副腎:5.07 膵臓:6.12 乳腺:6.73 唾液腺:4.92
CAGE 子宮:3.12 胎盤:2.81 前立腺:2.14 卵巣:3.45 精巣:1.71 心臓:- 骨格筋:- 食道:- 胃:2.26 腸:2.49 結腸:2.92     肝臓:2.60    肺:3.14 膀胱:4.02 腎臓:- 下垂体:2.73 甲状腺:- 副腎:3.35 膵臓:3.64 乳腺:3.66 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:4.67 食道:- 胃:- 腸:- 結腸:-     肝臓:1.96        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_016769
Gene ID 17127
Unigene ID Mm.73205
Probe set ID 1450472_s_at  [Mouse430_2]
Ensembl ID ENSMUSG00000032402

オーソログ対応遺伝子

ヒト[16]  NM_001145102, NM_001145103, NM_001145104, NM_005902
ラット [0]  

染色体

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遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

8774881
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0032924  activin receptor signaling pathway
GO:0007050  cell cycle arrest
GO:0045216  cell-cell junction organization
GO:0048589  developmental growth
GO:0048701  embryonic cranial skeleton morphogenesis
GO:0048617  embryonic foregut morphogenesis
GO:0009880  embryonic pattern specification
GO:0007492  endoderm development
GO:0019049  evasion of host defenses by virus
GO:0007369  gastrulation
GO:0001947  heart looping
GO:0006955  immune response
GO:0002520  immune system development
GO:0001701  in utero embryonic development
GO:0070306  lens fiber cell differentiation
GO:0001889  liver development
GO:0001707  mesoderm formation
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0050728  negative regulation of inflammatory response
GO:0045930  negative regulation of mitotic cell cycle
GO:0045668  negative regulation of osteoblast differentiation
GO:0033689  negative regulation of osteoblast proliferation
GO:0001933  negative regulation of protein amino acid phosphorylation
GO:0042177  negative regulation of protein catabolic process
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0002076  osteoblast development
GO:0001649  osteoblast differentiation
GO:0048340  paraxial mesoderm morphogenesis
GO:0060039  pericardium development
GO:0010694  positive regulation of alkaline phosphatase activity
GO:0030501  positive regulation of bone mineralization
GO:0030335  positive regulation of cell migration
GO:0032332  positive regulation of chondrocyte differentiation
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0051894  positive regulation of focal adhesion formation
GO:0032731  positive regulation of interleukin-1 beta production
GO:0050927  positive regulation of positive chemotaxis
GO:0051496  positive regulation of stress fiber formation
GO:0042993  positive regulation of transcription factor import into nucleus
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032916  positive regulation of transforming growth factor-beta3 production
GO:0050821  protein stabilization
GO:0051098  regulation of binding
GO:0050678  regulation of epithelial cell proliferation
GO:0050776  regulation of immune response
GO:0016202  regulation of striated muscle tissue development
GO:0006355  regulation of transcription, DNA-dependent
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0032909  regulation of transforming growth factor-beta2 production
GO:0001666  response to hypoxia
GO:0001501  skeletal system development
GO:0007183  SMAD protein complex assembly
GO:0001756  somitogenesis
GO:0042110  T cell activation
GO:0030878  thyroid gland development
GO:0006366  transcription from RNA polymerase II promoter
GO:0006351  transcription, DNA-dependent
GO:0060290  transdifferentiation
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0006810  transport

Cellular Component

GO:0005737  cytoplasm
GO:0005622  intracellular
GO:0005637  nuclear inner membrane
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0043234  protein complex
GO:0043235  receptor complex
GO:0071141  SMAD protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0031490  chromatin DNA binding
GO:0070410  co-SMAD binding
GO:0005518  collagen binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0019899  enzyme binding
GO:0046872  metal ion binding
GO:0019902  phosphatase binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0019901  protein kinase binding
GO:0070412  R-SMAD binding
GO:0043565  sequence-specific DNA binding
GO:0046332  SMAD binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding
GO:0005160  transforming growth factor beta receptor binding
GO:0030618  transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0043130  ubiquitin binding
GO:0031625  ubiquitin protein ligase binding
GO:0008270  zinc ion binding