MAD homolog 4 (Drosophila)

同義遺伝子名

Smad 4, Mothers against DPP homolog 4, DPC4, Dpc4, D18Wsu70e, SMAD 4, Deletion target in pancreatic carcinoma 4 homolog, Mothers against decapentaplegic homolog 4, MAD homolog 4 (Drosophila), Smad4, Madh4

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:48.60

小脳:128.90

脳幹:444.90

脳梁:-

松果体:-

末梢神経:57.30

脊柱:141.90

網膜:96.40

目:98.80

動脈:84.40

静脈:-

リンパ節:129.60

末梢血:71.90

脾臓:65.80

胸腺:138.30

骨髄:115.40

脂肪:1276.30

骨:62.60

皮膚:47.50

GeneChip

大脳:9.22

小脳:9.54

脳幹:-

脳梁:-

松果体:-

末梢神経:9.24

脊柱:8.51

網膜:9.20

目:9.69

動脈:-

静脈:10.10

リンパ節:9.88

末梢血:-

脾臓:9.75

胸腺:-

骨髄:8.82

脂肪:9.34

骨:9.06

皮膚:9.65

CAGE

大脳:4.32

小脳:-

脳幹:4.10

脳梁:-

松果体:-

末梢神経:-

脊柱:3.96

網膜:-

目:-

動脈:4.36

静脈:-

リンパ節:4.51

末梢血:-

脾臓:3.86

胸腺:4.58

骨髄:-

脂肪:-

骨:4.17

皮膚:4.76

RNA-seq

大脳:5.03

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:87.20

胎盤:41.40

前立腺:30.90

卵巣:68.90

精巣:29.60

心臓:55.80

骨格筋:71

食道:-

胃:-

腸:37

結腸:35.20

肝臓:45.30

肺:60.30

膀胱:66.20

腎臓:48.40

下垂体:155

甲状腺:-

副腎:848.90

膵臓:37.50

乳腺:120.80

唾液腺:54

GeneChip

子宮:10.03

胎盤:9.93

前立腺:10.38

卵巣:10.14

精巣:7.55

心臓:9.63

骨格筋:9.68

食道:-

胃:9.54

腸:10.29

結腸:-

肝臓:9.07

肺:9.70

膀胱:10.55

腎臓:9.21

下垂体:9.91

甲状腺:-

副腎:9.74

膵臓:8.69

乳腺:9.62

唾液腺:9.56

CAGE

子宮:4.61

胎盤:4.49

前立腺:4.98

卵巣:4.68

精巣:3.66

心臓:-

骨格筋:-

食道:-

胃:3.62

腸:5.00

結腸:5.05

肝臓:4.06

肺:4.73

膀胱:4.97

腎臓:-

下垂体:4.54

甲状腺:-

副腎:4.37

膵臓:4.53

乳腺:4.26

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:7.42

食道:-

胃:-

腸:-

結腸:-

肝臓:3.77

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_008540
Gene ID	17128
Unigene ID	Mm.100399
Probe set ID	1422485_at [Mouse430_2]
Ensembl ID	ENSMUSG00000024515

オーソログ対応遺伝子

ヒト[2]	NM_005359
ラット[1]	NM_019275

染色体

遺伝子ファミリー (Interpro ID)

IPR003619	MAD homology 1, Dwarfin-type
IPR013019	MAD homology, MH1
IPR001132	SMAD domain, Dwarfin-type
IPR017855	SMAD domain-like
IPR008984	SMAD/FHA domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0009952	anterior/posterior pattern formation
GO:0003190	atrioventricular valve formation
GO:0007411	axon guidance
GO:0030509	BMP signaling pathway
GO:0003360	brainstem development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0003279	cardiac septum development
GO:0008283	cell proliferation
GO:0048589	developmental growth
GO:0060956	endocardial cell differentiation
GO:0007492	endoderm development
GO:0042118	endothelial cell activation
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0048859	formation of anatomical boundary
GO:0007369	gastrulation
GO:0001702	gastrulation with mouth forming second
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0007498	mesoderm development
GO:0060548	negative regulation of cell death
GO:0030308	negative regulation of cell growth
GO:0008285	negative regulation of cell proliferation
GO:0042177	negative regulation of protein catabolic process
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0014033	neural crest cell differentiation
GO:0048663	neuron fate commitment
GO:0060021	palate development
GO:0030513	positive regulation of BMP signaling pathway
GO:0003251	positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	positive regulation of SMAD protein nuclear translocation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-dependent
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0051098	regulation of binding
GO:0042127	regulation of cell proliferation
GO:0051797	regulation of hair follicle development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-dependent
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0032909	regulation of transforming growth factor-beta2 production
GO:0001666	response to hypoxia
GO:0048733	sebaceous gland development
GO:0007183	SMAD protein complex assembly
GO:0060395	SMAD protein signal transduction
GO:0032525	somite rostral/caudal axis specification
GO:0048729	tissue morphogenesis
GO:0006351	transcription, DNA-dependent
GO:0007179	transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0032444	activin responsive factor complex
GO:0005813	centrosome
GO:0005737	cytoplasm
GO:0005622	intracellular
GO:0005634	nucleus
GO:0043234	protein complex
GO:0071141	SMAD protein complex
GO:0005667	transcription factor complex

Molecular Function

GO:0003682	chromatin binding
GO:0005518	collagen binding
GO:0003677	DNA binding
GO:0044212	DNA regulatory region binding
GO:0031005	filamin binding
GO:0070411	I-SMAD binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0070412	R-SMAD binding
GO:0043565	sequence-specific DNA binding
GO:0046332	SMAD binding
GO:0003700	transcription factor activity
GO:0030616	transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

MAD homolog 4 (Drosophila)

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function