MAD homolog 4 (Drosophila)

詳細情報を見る

同義遺伝子名

Smad 4, Mothers against DPP homolog 4, DPC4, Dpc4, D18Wsu70e, SMAD 4, Deletion target in pancreatic carcinoma 4 homolog, Mothers against decapentaplegic homolog 4, MAD homolog 4 (Drosophila), Smad4, Madh4

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:48.60 小脳:128.90 脳幹:444.90 脳梁:- 松果体:- 末梢神経:57.30 脊柱:141.90 網膜:96.40 目:98.80 動脈:84.40 静脈:- リンパ節:129.60 末梢血:71.90 脾臓:65.80 胸腺:138.30 骨髄:115.40 脂肪:1276.30 骨:62.60 皮膚:47.50
GeneChip 大脳:9.48 小脳:9.63 脳幹:- 脳梁:- 松果体:- 末梢神経:9.02 脊柱:8.53 網膜:10.88 目:10.63 動脈:- 静脈:10.28 リンパ節:10.03 末梢血:- 脾臓:9.76 胸腺:- 骨髄:8.87 脂肪:9.43 骨:9.19 皮膚:10.10
CAGE 大脳:4.32 小脳:- 脳幹:4.10 脳梁:- 松果体:- 末梢神経:- 脊柱:3.96 網膜:- 目:- 動脈:4.36 静脈:- リンパ節:4.51 末梢血:- 脾臓:3.86 胸腺:4.58 骨髄:- 脂肪:- 骨:4.17 皮膚:4.76
RNA-seq 大脳:5.03 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:87.20 胎盤:41.40 前立腺:30.90 卵巣:68.90 精巣:29.60 心臓:55.80 骨格筋:71 食道:- 胃:- 腸:37 結腸:35.20     肝臓:45.30        肺:60.30    膀胱:66.20 腎臓:48.40 下垂体:155 甲状腺:- 副腎:848.90 膵臓:37.50 乳腺:120.80 唾液腺:54
GeneChip 子宮:9.98 胎盤:9.73 前立腺:10.31 卵巣:9.85 精巣:6.71 心臓:9.32 骨格筋:9.94 食道:- 胃:8.56 腸:10.02 結腸:- 肝臓:8.60 肺:9.68 膀胱:10.33 腎臓:8.79 下垂体:9.50 甲状腺:- 副腎:10.24 膵臓:9.38 乳腺:9.80 唾液腺:10.51
CAGE 子宮:4.61 胎盤:4.49 前立腺:4.98 卵巣:4.68 精巣:3.66 心臓:- 骨格筋:- 食道:- 胃:3.62 腸:5.00 結腸:5.05     肝臓:4.06    肺:4.73 膀胱:4.97 腎臓:- 下垂体:4.54 甲状腺:- 副腎:4.37 膵臓:4.53 乳腺:4.26 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:7.42 食道:- 胃:- 腸:- 結腸:-     肝臓:3.77        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_008540
Gene ID 17128
Unigene ID Mm.100399
Probe set ID 1422486_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024515

オーソログ対応遺伝子

ヒト[2]  NM_005359
ラット[1]  NM_019275

染色体

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遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

9166592
9288972
9328171
9393997
9420335
9506519
9520423
9529255
9702197
9811942
10030593
10341708
10349617
10349636
10376010
10400677
10511616
10626800
10636910
10670756
10708952
10708962
10725249
10773876
10922068
11042159
11076861
11106407
11163184
11169847
11195460
11197776
11217851
11231077
11788714
11809702
11850197
11857783
12096346
12145309
12270938
12374795
12414519
12421925
12426318
12432092
12466851
12477932
12520002
12524424
12543979
12557227
12584607
12588798
12672795
12753287
12782414
12842913
12857787
12861029
12896967
12943993
14502566
14551209
14559231
14570593
14597578
14610273
14633973
14635047
14651998
14656760
14662776
14691138
14760387
14764653
15135236
15215210
15226823
15260977
15282343
15292219
15342483
15459107
15464984
15525990
15610403
15618518
15657445
15737733
15741177
15830383
15883213
15899814
15923624
15925496
15963972
16023633
16115198
16123376
16141072
16141073
16151019
16170355
16195406
16201233
16204035
16288217
16288220
16330325
16477644
16513794
16518688
16556916
16602821
16650383
16735447
16767220
16791201
16849541
16869739
16887829
16890162
17059883
17072319
17114584
17142805
17151782
17159989
17168649
17177285
17182123
17213286
17226765
17300215
17339028
17349581
17353364
17369830
17429065
17452626
17467076
17493607
17550966
17568773
17585069
17596282
17638848
17698011
17724086
17804724
17823941
17869237
17916348
17964566
17997817
18024957
18045816
18069690
18079204
18087045
18089935
18095342
18171930
18184786
18212064
18268325
18287559
18315922
18334251
18353861
18385792
18446800
18539898
18566469
18585065
18602626
18618014
18692037
18694570
18695001
18783722
18794355
18799693
18804071
18974875
18981480
18986983
19002110
19073883
19170762
19204324
19224984
19251704
19361496
19366691
19369394
19385047
19401440
19451264
19521500
19556507
19578404
19580641
19582869
19597490
19603510
19661464
19703995
19733164
19737861
19793887
19793892
19796622
19834456
19836350
19837676
19841536
19849841
19865483
19888897
19901970
19926752
19959815
20019187
20059953
20196951
20211142
20231279
20238004
20371653
20412781
20427661
20454682
20498064
20573697
20621052
20689554
20727852
20735985
20852387
20877696
20889504
20933217
20941375
20969946
21089072
21145499
21194568
21267068
21273545
21289624
21300867
21330551
21376704
21397841
21471525
21490069
21493862
21571225
21596989
21677750
21721476
21724602
21728174
21731673
21822279
21881210
21900682
22036565
22045334
22046433
22048127
22115830
22121131
22208613
22282597
22341455
22366399
22370000
22371886
22418736
22438570
22442258
22469842
22498737
22542937
22560297
22644379
22689943
22772757
22888807
22932243
22945649
23034633
23090737
23103586
23201680
23221368
23406900
23459943
23595735
23603491
23610450
23610558
23620745
23648546
23816882
23818325
23830984
23973329
23999427
24006258
24048844
24076600
24095903
24108699
24127404
24223846
24257627
24307592
24334458
24384683
24501173
24553180

遺伝子オントロジー  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0003190  atrioventricular valve formation
GO:0007411  axon guidance
GO:0030509  BMP signaling pathway
GO:0003360  brainstem development
GO:0001658  branching involved in ureteric bud morphogenesis
GO:0003279  cardiac septum development
GO:0008283  cell proliferation
GO:0048589  developmental growth
GO:0060956  endocardial cell differentiation
GO:0007492  endoderm development
GO:0042118  endothelial cell activation
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0048859  formation of anatomical boundary
GO:0007369  gastrulation
GO:0001702  gastrulation with mouth forming second
GO:0001701  in utero embryonic development
GO:0001822  kidney development
GO:0007498  mesoderm development
GO:0060548  negative regulation of cell death
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0042177  negative regulation of protein catabolic process
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0014033  neural crest cell differentiation
GO:0048663  neuron fate commitment
GO:0060021  palate development
GO:0030513  positive regulation of BMP signaling pathway
GO:0003251  positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0010862  positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391  positive regulation of SMAD protein nuclear translocation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0051098  regulation of binding
GO:0042127  regulation of cell proliferation
GO:0051797  regulation of hair follicle development
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0006355  regulation of transcription, DNA-dependent
GO:0017015  regulation of transforming growth factor beta receptor signaling pathway
GO:0032909  regulation of transforming growth factor-beta2 production
GO:0001666  response to hypoxia
GO:0048733  sebaceous gland development
GO:0007183  SMAD protein complex assembly
GO:0060395  SMAD protein signal transduction
GO:0032525  somite rostral/caudal axis specification
GO:0048729  tissue morphogenesis
GO:0006351  transcription, DNA-dependent
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0032444  activin responsive factor complex
GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0005622  intracellular
GO:0005634  nucleus
GO:0043234  protein complex
GO:0071141  SMAD protein complex
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0005518  collagen binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0031005  filamin binding
GO:0070411  I-SMAD binding
GO:0042802  identical protein binding
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0070412  R-SMAD binding
GO:0043565  sequence-specific DNA binding
GO:0046332  SMAD binding
GO:0003700  transcription factor activity
GO:0030616  transforming growth factor beta receptor, common-partner cytoplasmic mediator activity