Notch gene homolog 1 (Drosophila)

 詳細情報を見る

同義遺伝子名

Notch1, p300, Motch, Mis6, Notch gene homolog 1 (Drosophila), Tan1, Notch 1, Neurogenic locus notch homolog protein 1 precursor, Motch A, 9930111A19Rik, mT14, lin-12

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:93.80 小脳:92.10 脳幹:- 脳梁:- 松果体:- 末梢神経:152.90 脊柱:- 網膜:192.90 目:98.80 動脈:84.40 静脈:- リンパ節:226.80 末梢血:86.30 脾臓:158 胸腺:286.50 骨髄:- 脂肪:- 骨:125.20 皮膚:126.70
GeneChip 大脳:7.66 小脳:7.66 脳幹:- 脳梁:- 松果体:- 末梢神経:8.32 脊柱:7.99 網膜:8.84 目:8.62 動脈:- 静脈:8.35 リンパ節:9.01 末梢血:- 脾臓:9.08 胸腺:- 骨髄:8.93 脂肪:8.76 骨:8.70 皮膚:10.33
CAGE 大脳:2.35 小脳:- 脳幹:2.31 脳梁:- 松果体:- 末梢神経:- 脊柱:2.45 網膜:- 目:- 動脈:2.76 静脈:- リンパ節:2.54 末梢血:- 脾臓:2.37 胸腺:3.54 骨髄:- 脂肪:- 骨:2.97 皮膚:3.92
RNA-seq 大脳:2.23 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:43.60 胎盤:- 前立腺:30.90 卵巣:11.50 精巣:14.80 心臓:37.20 骨格筋:35.50 食道:- 胃:- 腸:73.90 結腸:35.20     肝臓:27.20        肺:80.30    膀胱:66.20 腎臓:16.10 下垂体:- 甲状腺:112.50 副腎:1273.30 膵臓:103.20 乳腺:97.90 唾液腺:-
GeneChip 子宮:8.98 胎盤:6.68 前立腺:8.56 卵巣:8.36 精巣:5.96 心臓:8.74 骨格筋:7.91 食道:- 胃:8.15 腸:8.06 結腸:- 肝臓:7.93 肺:10.55 膀胱:9.65 腎臓:7.48 下垂体:7.60 甲状腺:- 副腎:8.26 膵臓:8.03 乳腺:9.07 唾液腺:8.60
CAGE 子宮:2.98 胎盤:1.72 前立腺:2.94 卵巣:2.51 精巣:0.45 心臓:- 骨格筋:- 食道:- 胃:1.07 腸:2.03 結腸:2.46     肝臓:2.87    肺:3.81 膀胱:3.71 腎臓:- 下垂体:2.25 甲状腺:- 副腎:2.61 膵臓:2.66 乳腺:3.02 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.34 食道:- 胃:- 腸:- 結腸:-     肝臓:1.68        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_008714
Gene ID 18128
Unigene ID Mm.290610
Probe set ID 1418634_at  [Mouse430_2]
Ensembl ID ENSMUSG00000026923

オーソログ対応遺伝子

ヒト[1]  NM_017617
ラット[2]  NM_001105721

染色体

-

遺伝子ファミリー (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0042640  anagen
GO:0001525  angiogenesis
GO:0003180  aortic valve morphogenesis
GO:0060842  arterial endothelial cell differentiation
GO:0048708  astrocyte differentiation
GO:0003162  atrioventricular node development
GO:0003181  atrioventricular valve morphogenesis
GO:0009912  auditory receptor cell fate commitment
GO:0007409  axonogenesis
GO:0048754  branching morphogenesis of a tube
GO:0003209  cardiac atrium morphogenesis
GO:0003207  cardiac chamber formation
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0003214  cardiac left ventricle morphogenesis
GO:0060038  cardiac muscle cell proliferation
GO:0055008  cardiac muscle tissue morphogenesis
GO:0003213  cardiac right atrium morphogenesis
GO:0003219  cardiac right ventricle formation
GO:0060411  cardiac septum morphogenesis
GO:0060948  cardiac vascular smooth muscle cell development
GO:0003208  cardiac ventricle morphogenesis
GO:0030154  cell differentiation
GO:0045165  cell fate commitment
GO:0001708  cell fate specification
GO:0003273  cell migration involved in endocardial cushion formation
GO:0071372  cellular response to follicle-stimulating hormone stimulus
GO:0007386  compartment specification
GO:0060982  coronary artery morphogenesis
GO:0003169  coronary vein morphogenesis
GO:0007368  determination of left/right symmetry
GO:0009790  embryonic development
GO:0035116  embryonic hindlimb morphogenesis
GO:0030326  embryonic limb morphogenesis
GO:0060956  endocardial cell differentiation
GO:0003203  endocardial cushion morphogenesis
GO:0003157  endocardium development
GO:0003160  endocardium morphogenesis
GO:0007492  endoderm development
GO:0008544  epidermis development
GO:0001837  epithelial to mesenchymal transition
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0030900  forebrain development
GO:0007440  foregut morphogenesis
GO:0010001  glial cell differentiation
GO:0003241  growth involved in heart morphogenesis
GO:0031069  hair follicle morphogenesis
GO:0007507  heart development
GO:0001947  heart looping
GO:0006959  humoral immune response
GO:0001701  in utero embryonic development
GO:0002437  inflammatory response to antigenic stimulus
GO:0030216  keratinocyte differentiation
GO:0070986  left/right axis specification
GO:0001889  liver development
GO:0030324  lung development
GO:0014031  mesenchymal cell development
GO:0003192  mitral valve formation
GO:0007275  multicellular organismal development
GO:0030514  negative regulation of BMP signaling pathway
GO:0045955  negative regulation of calcium ion-dependent exocytosis
GO:0043086  negative regulation of catalytic activity
GO:0060548  negative regulation of cell death
GO:0045596  negative regulation of cell differentiation
GO:0090051  negative regulation of cell migration involved in sprouting angiogenesis
GO:0008285  negative regulation of cell proliferation
GO:0010812  negative regulation of cell-substrate adhesion
GO:0060253  negative regulation of glial cell proliferation
GO:0045662  negative regulation of myoblast differentiation
GO:0010832  negative regulation of myotube differentiation
GO:0050768  negative regulation of neurogenesis
GO:0045665  negative regulation of neuron differentiation
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0030279  negative regulation of ossification
GO:0045668  negative regulation of osteoblast differentiation
GO:0046533  negative regulation of photoreceptor cell differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0021915  neural tube development
GO:0030182  neuron differentiation
GO:0048663  neuron fate commitment
GO:0007219  Notch signaling pathway
GO:0002051  osteoblast fate commitment
GO:0003344  pericardium morphogenesis
GO:0043065  positive regulation of apoptosis
GO:0048711  positive regulation of astrocyte differentiation
GO:0030513  positive regulation of BMP signaling pathway
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045603  positive regulation of endothelial cell differentiation
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010718  positive regulation of epithelial to mesenchymal transition
GO:0045687  positive regulation of glial cell differentiation
GO:0046427  positive regulation of JAK-STAT cascade
GO:0045618  positive regulation of keratinocyte differentiation
GO:0002052  positive regulation of neuroblast proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007221  positive regulation of transcription of Notch receptor target
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0060740  prostate gland epithelium morphogenesis
GO:0003184  pulmonary valve morphogenesis
GO:0003264  regulation of cardioblast proliferation
GO:0030334  regulation of cell migration
GO:0042127  regulation of cell proliferation
GO:0050793  regulation of developmental process
GO:0050678  regulation of epithelial cell proliferation
GO:0060768  regulation of epithelial cell proliferation involved in prostate gland development
GO:0010468  regulation of gene expression
GO:0050767  regulation of neurogenesis
GO:0003270  regulation of second heart field cardioblast proliferation by Notch signaling pathway
GO:0014807  regulation of somitogenesis
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0003256  regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006355  regulation of transcription, DNA-dependent
GO:0032495  response to muramyl dipeptide
GO:0060528  secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0048103  somatic stem cell division
GO:0007283  spermatogenesis
GO:0002040  sprouting angiogenesis
GO:0006351  transcription, DNA-dependent
GO:0035148  tube lumen formation
GO:0060979  vasculogenesis involved in coronary vascular morphogenesis
GO:0060843  venous endothelial cell differentiation
GO:0060412  ventricular septum morphogenesis
GO:0003222  ventricular trabecular myocardium morphogenesis

Cellular Component

GO:0001669  acrosomal vesicle
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005794  Golgi apparatus
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0016020  membrane
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0003682  chromatin binding
GO:0031490  chromatin DNA binding
GO:0019899  enzyme binding
GO:0004857  enzyme inhibitor activity
GO:0046872  metal ion binding
GO:0005515  protein binding
GO:0004872  receptor activity
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity