neurotrophic tyrosine kinase, receptor, type 2

詳細情報を見る

同義遺伝子名

GP145-TrkB/GP95-TrkB, BDNF/NT-3 growth factors receptor precursor, Trk-B, C030027L06Rik, Ntrk2, AI848316, Trkb, TrkB tyrosine kinase, neurotrophic tyrosine kinase, receptor, type 2, Neurotrophic tyrosine kinase receptor type 2, trkB, Tkrb

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:451.50 小脳:644.70 脳幹:444.90 脳梁:- 松果体:- 末梢神経:76.40 脊柱:283.70 網膜:225 目:45.60 動脈:337.60 静脈:- リンパ節:- 末梢血:- 脾臓:13.20 胸腺:- 骨髄:- 脂肪:- 骨:12.50 皮膚:71.30
GeneChip 大脳:6.66 小脳:4.90 脳幹:- 脳梁:- 松果体:- 末梢神経:4.99 脊柱:5.88 網膜:4.12 目:4.10 動脈:- 静脈:4.29 リンパ節:3.81 末梢血:- 脾臓:3.83 胸腺:- 骨髄:3.76 脂肪:5.29 骨:3.88 皮膚:4.20
CAGE 大脳:5.35 小脳:- 脳幹:5.56 脳梁:- 松果体:- 末梢神経:- 脊柱:5.37 網膜:- 目:- 動脈:4.80 静脈:- リンパ節:1.98 末梢血:- 脾臓:0.41 胸腺:1.75 骨髄:- 脂肪:- 骨:1.97 皮膚:3.25
RNA-seq 大脳:52.37 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:43.60 胎盤:41.40 前立腺:- 卵巣:23 精巣:- 心臓:18.60 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:9.10        肺:-    膀胱:66.20 腎臓:- 下垂体:51.70 甲状腺:112.50 副腎:- 膵臓:159.50 乳腺:71.80 唾液腺:-
GeneChip 子宮:4 胎盤:3.94 前立腺:3.98 卵巣:4.44 精巣:3.92 心臓:4.14 骨格筋:4.30 食道:- 胃:3.93 腸:3.88 結腸:- 肝臓:4.18 肺:4.07 膀胱:4.04 腎臓:4.24 下垂体:4.81 甲状腺:- 副腎:4.16 膵臓:4.31 乳腺:4.40 唾液腺:4.12
CAGE 子宮:3.30 胎盤:2.12 前立腺:2.43 卵巣:3.26 精巣:0.45 心臓:- 骨格筋:- 食道:- 胃:1.35 腸:0.58 結腸:0.57     肝臓:1.45    肺:2.03 膀胱:2.50 腎臓:- 下垂体:4.54 甲状腺:- 副腎:2.46 膵臓:2.56 乳腺:3.05 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.34 食道:- 胃:- 腸:- 結腸:-     肝臓:0        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_008745
Gene ID 18212
Unigene ID Mm.130054
Probe set ID 1420837_at  [Mouse430_2]
Ensembl ID ENSMUSG00000055254

オーソログ対応遺伝子

ヒト[14]  NM_001007097, NM_001018064, NM_001018065, NM_001018066, NM_006180
ラット[3]  NM_001163168, NM_001163169, NM_012731, NM_001018066, NM_006180

染色体

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遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

1327010
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遺伝子オントロジー  (GO ID)

Biological Process

GO:0031547  brain-derived neurotrophic factor receptor signaling pathway
GO:0030154  cell differentiation
GO:0021954  central nervous system neuron development
GO:0021987  cerebral cortex development
GO:0007631  feeding behavior
GO:0014047  glutamate secretion
GO:0007612  learning
GO:0007616  long-term memory
GO:0060291  long-term synaptic potentiation
GO:0042490  mechanoreceptor differentiation
GO:0007275  multicellular organismal development
GO:0043524  negative regulation of neuron apoptosis
GO:0007399  nervous system development
GO:0007528  neuromuscular junction development
GO:0030182  neuron differentiation
GO:0001764  neuron migration
GO:0048709  oligodendrocyte differentiation
GO:0048935  peripheral nervous system neuron development
GO:0016310  phosphorylation
GO:0050772  positive regulation of axonogenesis
GO:0008284  positive regulation of cell proliferation
GO:0010628  positive regulation of gene expression
GO:0043410  positive regulation of MAPKKK cascade
GO:0010976  positive regulation of neuron projection development
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0051968  positive regulation of synaptic transmission, glutamatergic
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0050773  regulation of dendrite development
GO:0043408  regulation of MAPKKK cascade
GO:0019222  regulation of metabolic process
GO:0046928  regulation of neurotransmitter secretion
GO:0051896  regulation of protein kinase B signaling cascade
GO:0032314  regulation of Rac GTPase activity
GO:0046548  retinal rod cell development
GO:0007169  transmembrane receptor protein tyrosine kinase signaling pathway
GO:0001570  vasculogenesis

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0009986  cell surface
GO:0005829  cytosol
GO:0030425  dendrite
GO:0043197  dendritic spine
GO:0005768  endosome
GO:0060076  excitatory synapse
GO:0030426  growth cone
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0005622  intracellular
GO:0016020  membrane
GO:0043679  nerve terminal
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane
GO:0048786  presynaptic active zone
GO:0043195  terminal button

Molecular Function

GO:0005524  ATP binding
GO:0048403  brain-derived neurotrophic factor binding
GO:0060175  brain-derived neurotrophic factor receptor activity
GO:0046875  ephrin receptor binding
GO:0016301  kinase activity
GO:0043121  neurotrophin binding
GO:0005030  neurotrophin receptor activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0004672  protein kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups
GO:0004714  transmembrane receptor protein tyrosine kinase activity