platelet derived growth factor, B polypeptide

詳細情報を見る

同義遺伝子名

PDGF-B, Pdgfb, platelet derived growth factor, B polypeptide, Sis, c-sis, PDGF-2, Platelet-derived growth factor beta polypeptide, PDGF B-chain, Platelet-derived growth factor B chain precursor

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:3.50 小脳:- 脳幹:31.80 脳梁:- 松果体:515.60 末梢神経:38.20 脊柱:- 網膜:- 目:7.60 動脈:- 静脈:- リンパ節:97.20 末梢血:- 脾臓:26.30 胸腺:19.80 骨髄:- 脂肪:- 骨:12.50 皮膚:-
GeneChip 大脳:6.14 小脳:5.82 脳幹:- 脳梁:- 松果体:- 末梢神経:5.63 脊柱:6.14 網膜:5.19 目:5.81 動脈:- 静脈:5.68 リンパ節:6.02 末梢血:- 脾臓:5.81 胸腺:- 骨髄:5.87 脂肪:6.58 骨:5.82 皮膚:6.48
CAGE 大脳:2.16 小脳:- 脳幹:2.24 脳梁:- 松果体:- 末梢神経:- 脊柱:2.42 網膜:- 目:- 動脈:2.63 静脈:- リンパ節:1.98 末梢血:- 脾臓:2.27 胸腺:1.85 骨髄:- 脂肪:- 骨:2.09 皮膚:2.03
RNA-seq 大脳:4.46 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:43.60 胎盤:55.20 前立腺:- 卵巣:11.50 精巣:- 心臓:18.60 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:20.10    膀胱:- 腎臓:- 下垂体:- 甲状腺:112.50 副腎:- 膵臓:- 乳腺:32.60 唾液腺:108
GeneChip 子宮:5.92 胎盤:7.47 前立腺:5.99 卵巣:6.19 精巣:5.42 心臓:7.30 骨格筋:6.91 食道:- 胃:6.12 腸:5.51 結腸:- 肝臓:6.03 肺:7.94 膀胱:6.10 腎臓:6.57 下垂体:5.71 甲状腺:- 副腎:5.84 膵臓:6.85 乳腺:6.56 唾液腺:5.60
CAGE 子宮:2.30 胎盤:3.35 前立腺:1.02 卵巣:2.45 精巣:0 心臓:- 骨格筋:- 食道:- 胃:2.52 腸:1.49 結腸:2.16     肝臓:1.22    肺:4.24 膀胱:2.05 腎臓:- 下垂体:2.42 甲状腺:- 副腎:3.27 膵臓:2.33 乳腺:2.80 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:3.33 食道:- 胃:- 腸:- 結腸:-     肝臓:1.54        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_011057
Gene ID 18591
Unigene ID Mm.144089
Probe set ID 1450413_at  [Mouse430_2]
Ensembl ID ENSMUSG00000000489

オーソログ対応遺伝子

ヒト[6]  NM_002608, NM_033016
ラット[2]  NM_031524, NM_033016

染色体

-

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1324805
1340209
1354638
1358803
1386365
1592235
1879607
2045107
2155144
2212004
2458212
2566557
2882510
2885263
2892786
2900461
2984666
2985974
2996133
3471390
6093261
6291150
6304883
6306471
6308764
6328284
6594688
7587381
7588258
7588749
7590346
7590746
7622571
7640655
7649812
7664667
7720681
7743923
7760819
7774558
7892260
7958863
8012111
8094075
8104059
8199414
8258699
8302575
8314081
8318539
8364887
8401507
8406449
8432535
8432540
8463278
8482578
8597630
8660379
8662221
8689409
8900172
8901196
8908201
8954727
8988177
9027489
9211853
9226373
9271678
9339365
9367982
9374392
9560246
9693135
9734598
9812194
10349636
10362801
10375497
10384052
10419690
10438878
10591541
10652433
10700190
10806482
10926756
10980138
11042159
11076861
11217851
11239463
11264163
11331305
11337941
11439183
11811556
11855867
11925102
11940581
12037011
12169633
12176888
12351455
12368212
12381667
12466851
12477932
12528182
12588999
12651897
12897053
14514732
14522834
14561699
14610273
14644167
14745002
14963008
14966296
14988091
14996938
15073150
15084468
15183724
15239958
15254974
15322537
15489334
15580568
15640362
15735680
15838875
15844178
15907784
15919073
15965785
16104380
16107612
16127167
16141072
16141073
16456542
16470244
16641085
16644864
16723717
16807374
16831408
16842882
16869712
17141159
17289920
17296941
17438529
17545544
17560563
17573777
17724602
18070924
18180311
18194151
18213577
18213589
18272846
18441206
18460333
18508041
18559345
18594512
18606782
18663143
18765673
18799693
18804439
18922925
19048116
19146952
19165863
19219070
19429912
19605488
19619540
19734317
19734356
19896531
19998489
20035058
20048339
20133221
20230750
20299672
20364125
20452974
20501841
20506153
20619341
20643125
20687910
20939912
20944627
21089075
21173261
21200430
21216974
21267068
21421844
21550017
21593423
21606590
21673305
21677750
21677873
21693521
21878906
21978952
22138754
22264326
22369999
22387002
22516201
22560297
22627278
22730381
22880002
22885106
22975322
23213481
23426945
23477786
23525041
23529017
23570836
23750244
23831851
23913003
24472833

遺伝子オントロジー  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0032147  activation of protein kinase activity
GO:0032148  activation of protein kinase B activity
GO:0007596  blood coagulation
GO:0048514  blood vessel morphogenesis
GO:0060445  branching involved in salivary gland morphogenesis
GO:0060947  cardiac vascular smooth muscle cell differentiation
GO:0060326  cell chemotaxis
GO:0030031  cell projection assembly
GO:0071363  cellular response to growth factor stimulus
GO:0071506  cellular response to mycophenolic acid
GO:0001892  embryonic placenta development
GO:0060664  epithelial cell proliferation involved in salivary gland morphogenesis
GO:0007507  heart development
GO:0002548  monocyte chemotaxis
GO:0007275  multicellular organismal development
GO:0030336  negative regulation of cell migration
GO:0010512  negative regulation of phosphatidylinositol biosynthetic process
GO:0010544  negative regulation of platelet activation
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0045908  negative regulation of vasodilation
GO:0018105  peptidyl-serine phosphorylation
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0050918  positive chemotaxis
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0051781  positive regulation of cell division
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0050921  positive regulation of chemotaxis
GO:0045737  positive regulation of cyclin-dependent protein kinase activity
GO:0045740  positive regulation of DNA replication
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0045743  positive regulation of fibroblast growth factor receptor signaling pathway
GO:0048146  positive regulation of fibroblast proliferation
GO:0003104  positive regulation of glomerular filtration
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0045840  positive regulation of mitosis
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0043552  positive regulation of phosphoinositide 3-kinase activity
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0031954  positive regulation of protein amino acid autophosphorylation
GO:0014911  positive regulation of smooth muscle cell migration
GO:0048661  positive regulation of smooth muscle cell proliferation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0045907  positive regulation of vasoconstriction
GO:0006468  protein amino acid phosphorylation
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0009611  response to wounding
GO:0006929  substrate-bound cell migration
GO:0007179  transforming growth factor beta receptor signaling pathway

Cellular Component

GO:0016323  basolateral plasma membrane
GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0016020  membrane

Molecular Function

GO:0042056  chemoattractant activity
GO:0005518  collagen binding
GO:0008083  growth factor activity
GO:0048407  platelet-derived growth factor binding
GO:0005161  platelet-derived growth factor receptor binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity
GO:0016176  superoxide-generating NADPH oxidase activator activity