eukaryotic translation initiation factor 2-alpha kinase 2

同義遺伝子名

4732414G15Rik, Serine/threonine-protein kinase TIK, Interferon-inducible RNA-dependent protein kinase, PKR, IFN- type I-induced and dsRNA-activated kinase, Prkr, eIF-2 alpha, 2310047A08Rik, AI467567, AI747578, dsRNA-activated kinase, Tik, P1/eIF-2A protein kinase, Protein kinase RNA-activated, Eif2ak2, p68 kinase, Pkr

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:8.70

小脳:-

脳幹:31.80

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:84.40

静脈:-

リンパ節:-

末梢血:28.80

脾臓:144.80

胸腺:9.90

骨髄:-

脂肪:-

骨:12.50

皮膚:31.70

GeneChip

大脳:6.13

小脳:6.37

脳幹:-

脳梁:-

松果体:-

末梢神経:6.74

脊柱:6.25

網膜:6.08

目:6.27

動脈:-

静脈:6.52

リンパ節:7.45

末梢血:-

脾臓:7.02

胸腺:-

骨髄:7.74

脂肪:6.53

骨:7.04

皮膚:7.36

CAGE

大脳:1.53

小脳:-

脳幹:1.98

脳梁:-

松果体:-

末梢神経:-

脊柱:2.15

網膜:-

目:-

動脈:3.60

静脈:-

リンパ節:4.51

末梢血:-

脾臓:3.60

胸腺:2.76

骨髄:-

脂肪:-

骨:3.73

皮膚:2.76

RNA-seq

大脳:1.12

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:27.60

前立腺:30.90

卵巣:-

精巣:-

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:-

肺:10

膀胱:-

腎臓:-

下垂体:25.80

甲状腺:-

副腎:-

膵臓:-

乳腺:45.70

唾液腺:54

GeneChip

子宮:7.41

胎盤:7.12

前立腺:6.40

卵巣:6.91

精巣:5.81

心臓:6.62

骨格筋:6.39

食道:-

胃:6.49

腸:6.96

結腸:-

肝臓:6.51

肺:6.59

膀胱:6.88

腎臓:6.26

下垂体:6.67

甲状腺:-

副腎:6.85

膵臓:6.47

乳腺:6.82

唾液腺:7.29

CAGE

子宮:4.01

胎盤:3.21

前立腺:2.77

卵巣:3.09

精巣:2.51

心臓:-

骨格筋:-

食道:-

胃:3.17

腸:4.08

結腸:3.59

肝臓:3.02

肺:3.46

膀胱:3.08

腎臓:-

下垂体:3.05

甲状腺:-

副腎:3.18

膵臓:2.03

乳腺:3.75

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.22

食道:-

胃:-

腸:-

結腸:-

肝臓:3.39

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_011163
Gene ID	19106
Unigene ID	Mm.378990
Probe set ID	1422006_at [Mouse430_2]
Ensembl ID	ENSMUSG00000024079

オーソログ対応遺伝子

ヒト[5]	NM_001135651, NM_001135652, NM_002759
ラット[5]	NM_001135651, NM_001135652, NM_002759

染色体

遺伝子ファミリー (Interpro ID)

IPR001159	Double-stranded RNA binding
IPR014720	Double-stranded RNA-binding-like
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0000186	activation of MAPKK activity
GO:0051607	defense response to virus
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0045087	innate immune response
GO:0033689	negative regulation of osteoblast proliferation
GO:0017148	negative regulation of translation
GO:0045071	negative regulation of viral genome replication
GO:0016310	phosphorylation
GO:0043065	positive regulation of apoptosis
GO:0032722	positive regulation of chemokine production
GO:0001819	positive regulation of cytokine production
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0006355	regulation of transcription, DNA-dependent
GO:0032496	response to lipopolysaccharide
GO:0009636	response to toxin
GO:0009615	response to virus
GO:0033197	response to vitamin E
GO:0006351	transcription, DNA-dependent
GO:0006412	translation
GO:0006413	translational initiation
GO:0006926	virus-infected cell apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm

Molecular Function

GO:0005524	ATP binding
GO:0003725	double-stranded RNA binding
GO:0016301	kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0003723	RNA binding
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0003743	translation initiation factor activity

eukaryotic translation initiation factor 2-alpha kinase 2

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function