presenilin 1

詳細情報を見る

同義遺伝子名

Psnl1, Ad3h, PS1, Psen1, PS-1, presenilin-1, S182, Presenilin-1, Protein S182, presenilin 1

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:-

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:15.80

GeneChip

大脳:9.03

小脳:9

脳幹:-

脳梁:-

松果体:-

末梢神経:9.41

脊柱:9.37

網膜:8.71

目:9.11

動脈:-

静脈:9.58

リンパ節:9.59

末梢血:-

脾臓:9.31

胸腺:-

骨髄:9.61

脂肪:9.10

骨:9.46

皮膚:10

CAGE

大脳:3.80

小脳:-

脳幹:3.98

脳梁:-

松果体:-

末梢神経:-

脊柱:4.05

網膜:-

目:-

動脈:3.69

静脈:-

リンパ節:4.24

末梢血:-

脾臓:3.65

胸腺:3.72

骨髄:-

脂肪:-

骨:3.69

皮膚:4.25

RNA-seq

大脳:10.68

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:-

肺:10

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

GeneChip

子宮:9.48

胎盤:10.42

前立腺:9.83

卵巣:9.27

精巣:10.54

心臓:9.01

骨格筋:9.28

食道:-

胃:10.24

腸:10.82

結腸:-

肝臓:9.07

肺:9.41

膀胱:9.81

腎臓:9.99

下垂体:10.15

甲状腺:-

副腎:9.12

膵臓:9.30

乳腺:9.32

唾液腺:10.03

CAGE

子宮:4.13

胎盤:4.45

前立腺:4.02

卵巣:3.86

精巣:6.13

心臓:-

骨格筋:-

食道:-

胃:4.00

腸:4.60

結腸:4.76

肝臓:3.74

肺:3.91

膀胱:4.17

腎臓:-

下垂体:4.27

甲状腺:-

副腎:3.73

膵臓:4.04

乳腺:3.89

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:3.75

食道:-

胃:-

腸:-

結腸:-

肝臓:4.84

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_008943
Gene ID	19164
Unigene ID	Mm.99811
Probe set ID	1421853_at [Mouse430_2]
Ensembl ID	ENSMUSG00000019969

オーソログ対応遺伝子

ヒト[4]	NM_000021, NM_007318
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR006639	Peptidase A22, presenilin signal peptide
IPR001108	Peptidase A22A, presenilin
IPR002031	Peptidase A22A, presenilin 1

遺伝子オントロジー (GO ID)

Biological Process

GO:0000186	activation of MAPKK activity
GO:0042987	amyloid precursor protein catabolic process
GO:0042640	anagen
GO:0006915	apoptosis
GO:0000045	autophagic vacuole formation
GO:0006914	autophagy
GO:0034205	beta-amyloid formation
GO:0050435	beta-amyloid metabolic process
GO:0001568	blood vessel development
GO:0007420	brain development
GO:0048854	brain morphogenesis
GO:0021870	Cajal-Retzius cell differentiation
GO:0070588	calcium ion transmembrane transport
GO:0006816	calcium ion transport
GO:0007155	cell adhesion
GO:0001708	cell fate specification
GO:0016337	cell-cell adhesion
GO:0006874	cellular calcium ion homeostasis
GO:0044267	cellular protein metabolic process
GO:0021795	cerebral cortex cell migration
GO:0021987	cerebral cortex development
GO:0015871	choline transport
GO:0021904	dorsal/ventral neural tube patterning
GO:0009790	embryonic development
GO:0030326	embryonic limb morphogenesis
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0050673	epithelial cell proliferation
GO:0030900	forebrain development
GO:0007507	heart development
GO:0001947	heart looping
GO:0002244	hemopoietic progenitor cell differentiation
GO:0015813	L-glutamate transport
GO:0007611	learning or memory
GO:0040011	locomotion
GO:0006509	membrane protein ectodomain proteolysis
GO:0007613	memory
GO:0006839	mitochondrial transport
GO:0002573	myeloid leukocyte differentiation
GO:0043066	negative regulation of apoptosis
GO:0050771	negative regulation of axonogenesis
GO:0007175	negative regulation of epidermal growth factor receptor activity
GO:0043524	negative regulation of neuron apoptosis
GO:0001933	negative regulation of protein amino acid phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0051444	negative regulation of ubiquitin-protein ligase activity
GO:0022008	neurogenesis
GO:0051402	neuron apoptosis
GO:0048666	neuron development
GO:0030182	neuron differentiation
GO:0001764	neuron migration
GO:0007220	Notch receptor processing
GO:0007219	Notch signaling pathway
GO:0043065	positive regulation of apoptosis
GO:0043085	positive regulation of catalytic activity
GO:0050820	positive regulation of coagulation
GO:0043406	positive regulation of MAP kinase activity
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0045860	positive regulation of protein kinase activity
GO:0001921	positive regulation of receptor recycling
GO:0009791	post-embryonic development
GO:0006486	protein amino acid glycosylation
GO:0051604	protein maturation
GO:0016485	protein processing
GO:0015031	protein transport
GO:0006508	proteolysis
GO:0007176	regulation of epidermal growth factor receptor activity
GO:0042325	regulation of phosphorylation
GO:0043393	regulation of protein binding
GO:0060075	regulation of resting membrane potential
GO:0048167	regulation of synaptic plasticity
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0006974	response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0035282	segmentation
GO:0048705	skeletal system morphogenesis
GO:0043589	skin morphogenesis
GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis
GO:0001756	somitogenesis
GO:0016080	synaptic vesicle targeting
GO:0002286	T cell activation during immune response
GO:0050852	T cell receptor signaling pathway
GO:0048538	thymus development

Cellular Component

GO:0016324	apical plasma membrane
GO:0030424	axon
GO:0005938	cell cortex
GO:0043025	cell soma
GO:0009986	cell surface
GO:0005813	centrosome
GO:0035253	ciliary rootlet
GO:0031410	cytoplasmic vesicle
GO:0030425	dendrite
GO:0043198	dendritic shaft
GO:0005783	endoplasmic reticulum
GO:0070765	gamma-secretase complex
GO:0005794	Golgi apparatus
GO:0030426	growth cone
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0005622	intracellular
GO:0000776	kinetochore
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0045121	membrane raft
GO:0043227	membrane-bounded organelle
GO:0005743	mitochondrial inner membrane
GO:0005739	mitochondrion
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0031965	nuclear membrane
GO:0005640	nuclear outer membrane
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0005791	rough endoplasmic reticulum
GO:0005790	smooth endoplasmic reticulum
GO:0030018	Z disc

Molecular Function

GO:0004190	aspartic-type endopeptidase activity
GO:0008013	beta-catenin binding
GO:0045296	cadherin binding
GO:0005262	calcium channel activity
GO:0004175	endopeptidase activity
GO:0016787	hydrolase activity
GO:0030165	PDZ domain binding
GO:0008233	peptidase activity
GO:0005515	protein binding

presenilin 1

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function