protein tyrosine phosphatase, non-receptor type 2

 詳細情報を見る

同義遺伝子名

Ptpt, Ptpn2, protein tyrosine phosphatase, non-receptor type 2, Protein-tyrosine phosphatase PTP-2, TC-PTP, AI325124, Tyrosine-protein phosphatase non-receptor type 2, MPTP

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:33 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:19.10 脊柱:- 網膜:128.60 目:60.80 動脈:- 静脈:- リンパ節:43.20 末梢血:143.80 脾臓:171.20 胸腺:128.40 骨髄:179.50 脂肪:- 骨:37.60 皮膚:63.30
GeneChip 大脳:8.17 小脳:8.71 脳幹:- 脳梁:- 松果体:- 末梢神経:7.35 脊柱:7.92 網膜:10.31 目:9.93 動脈:- 静脈:9.28 リンパ節:10.10 末梢血:- 脾臓:9.72 胸腺:- 骨髄:9.66 脂肪:8.92 骨:10.09 皮膚:9.52
CAGE 大脳:3.50 小脳:- 脳幹:2.98 脳梁:- 松果体:- 末梢神経:- 脊柱:2.98 網膜:- 目:- 動脈:3.49 静脈:- リンパ節:4.48 末梢血:- 脾臓:3.50 胸腺:3.62 骨髄:- 脂肪:- 骨:3.52 皮膚:3.37
RNA-seq 大脳:3.12 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:174.50 胎盤:165.70 前立腺:30.90 卵巣:91.90 精巣:66.50 心臓:93 骨格筋:- 食道:- 胃:65.50 腸:- 結腸:17.60     肝臓:18.10        肺:50.20    膀胱:- 腎臓:16.10 下垂体:25.80 甲状腺:- 副腎:- 膵臓:37.50 乳腺:75.10 唾液腺:-
GeneChip 子宮:9.23 胎盤:10.18 前立腺:8.98 卵巣:9.31 精巣:9.06 心臓:8.94 骨格筋:8.81 食道:- 胃:9.01 腸:9.46 結腸:- 肝臓:8.22 肺:8.81 膀胱:8.82 腎臓:8.59 下垂体:9.11 甲状腺:- 副腎:9.77 膵臓:8.27 乳腺:9.34 唾液腺:9.83
CAGE 子宮:3.60 胎盤:3.70 前立腺:3.32 卵巣:3.65 精巣:3.78 心臓:- 骨格筋:- 食道:- 胃:3.39 腸:3.42 結腸:3.45     肝臓:3.45    肺:3.38 膀胱:3.16 腎臓:- 下垂体:3.53 甲状腺:- 副腎:3.60 膵臓:2.66 乳腺:3.44 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:3.50 食道:- 胃:- 腸:- 結腸:-     肝臓:2.73        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_008977
Gene ID 19255
Unigene ID Mm.260433
Probe set ID 1438562_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024539

オーソログ対応遺伝子

ヒト[5]  NM_001207013, NM_002828, NM_080422, NM_080423
ラット [0]  

染色体

18E1  [67,825,165  -  67,884,249]

遺伝子ファミリー (Interpro ID)

IPR000242  Protein-tyrosine phosphatase, receptor/non-receptor type

Link to Pubmed  (Pubmed ID)

1283199
1731319
1733852
8267598
8534367
8875997
9271584
10349636
10922068
11042159
11076861
11217851
11907034
11909529
12138178
12171910
12466851
12477932
12520002
12612081
12847239
12904583
14600148
14610273
14726372
14744882
14966296
15489334
15592458
15632081
15696169
16141072
16141073
16198645
16602821
16705167
16971512
17210636
17234741
17967808
18775329
18799693
18819921
18948751
19474293
19727691
19755676
19930043
20059965
20111595
20421975
20473312
20484139
20924113
20940300
21216966
21267068
21435452
21677750
21968903
22000926
22080863
22124607
22252315
22590589
23135963
23166300
24040033
24442435
24445916

遺伝子オントロジー  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0016311  dephosphorylation
GO:0030218  erythrocyte differentiation
GO:0042593  glucose homeostasis
GO:0008286  insulin receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0050922  negative regulation of chemotaxis
GO:0042059  negative regulation of epidermal growth factor receptor signaling pathway
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0050728  negative regulation of inflammatory response
GO:0046627  negative regulation of insulin receptor signaling pathway
GO:0060336  negative regulation of interferon-gamma-mediated signaling pathway
GO:0070104  negative regulation of interleukin-6-mediated signaling pathway
GO:0010888  negative regulation of lipid storage
GO:0045650  negative regulation of macrophage differentiation
GO:0050860  negative regulation of T cell receptor signaling pathway
GO:0010804  negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0060339  negative regulation of type I interferon-mediated signaling pathway
GO:0042518  negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524  negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527  negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0045722  positive regulation of gluconeogenesis
GO:0006470  protein amino acid dephosphorylation
GO:0030217  T cell differentiation

Cellular Component

GO:0005737  cytoplasm
GO:0005783  endoplasmic reticulum
GO:0005793  ER-Golgi intermediate compartment
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0016787  hydrolase activity
GO:0005178  integrin binding
GO:0004726  non-membrane spanning protein tyrosine phosphatase activity
GO:0016791  phosphatase activity
GO:0004721  phosphoprotein phosphatase activity
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0004725  protein tyrosine phosphatase activity
GO:0030971  receptor tyrosine kinase binding
GO:0019905  syntaxin binding