synuclein, alpha

同義遺伝子名

Snca, alpha-synuclein, Non-A4 component of amyloid precursor, NACP, synuclein, alpha, Alpha-synuclein, Non-A beta component of AD amyloid, alphaSYN

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:267.40

小脳:110.50

脳幹:190.70

脳梁:-

松果体:-

末梢神経:76.40

脊柱:-

網膜:321.40

目:-

動脈:-

静脈:-

リンパ節:21.60

末梢血:-

脾臓:52.70

胸腺:19.80

骨髄:-

脂肪:-

骨:12.50

皮膚:39.60

GeneChip

大脳:12.21

小脳:9.35

脳幹:-

脳梁:-

松果体:-

末梢神経:8.82

脊柱:9.54

網膜:6.99

目:6.66

動脈:-

静脈:11.23

リンパ節:5.23

末梢血:-

脾臓:10.29

胸腺:-

骨髄:13.06

脂肪:6.30

骨:12.88

皮膚:6.10

CAGE

大脳:4.54

小脳:-

脳幹:4.31

脳梁:-

松果体:-

末梢神経:-

脊柱:3.92

網膜:-

目:-

動脈:3.65

静脈:-

リンパ節:0.57

末梢血:-

脾臓:5.78

胸腺:1.06

骨髄:-

脂肪:-

骨:5.48

皮膚:1.94

RNA-seq

大脳:29.57

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:69

前立腺:30.90

卵巣:-

精巣:-

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:72.40

肺:20.10

膀胱:-

腎臓:-

下垂体:12.90

甲状腺:-

副腎:-

膵臓:-

乳腺:9.80

唾液腺:-

GeneChip

子宮:5.11

胎盤:9.33

前立腺:5.66

卵巣:5.58

精巣:5.23

心臓:9.28

骨格筋:5.95

食道:-

胃:5.79

腸:5.60

結腸:-

肝臓:5.91

肺:8.50

膀胱:5.34

腎臓:6.46

下垂体:6.21

甲状腺:-

副腎:7.08

膵臓:7.54

乳腺:6.19

唾液腺:6.98

CAGE

子宮:0.31

胎盤:2.80

前立腺:1.77

卵巣:0.76

精巣:0.45

心臓:-

骨格筋:-

食道:-

胃:0.67

腸:1.05

結腸:0

肝臓:1.89

肺:3.75

膀胱:1.92

腎臓:-

下垂体:2.10

甲状腺:-

副腎:1.70

膵臓:0.84

乳腺:1.50

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.26

食道:-

胃:-

腸:-

結腸:-

肝臓:0.82

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_009221
Gene ID	20617
Unigene ID	Mm.17484
Probe set ID	1418493_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000025889

オーソログ対応遺伝子

ヒト[16]	NM_000345, NM_001146054, NM_001146055, NM_007308
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR002460	Alpha-synuclein
IPR002462	Gamma-synuclein
IPR001058	Synuclein

遺伝子オントロジー (GO ID)

Biological Process

GO:0006919	activation of caspase activity
GO:0008344	adult locomotory behavior
GO:0048148	behavioral response to cocaine
GO:0071280	cellular response to copper ion
GO:0034599	cellular response to oxidative stress
GO:0042416	dopamine biosynthetic process
GO:0042417	dopamine metabolic process
GO:0006631	fatty acid metabolic process
GO:0060291	long-term synaptic potentiation
GO:0016044	membrane organization
GO:0001774	microglial cell activation
GO:0042775	mitochondrial ATP synthesis coupled electron transport
GO:0007006	mitochondrial membrane organization
GO:0043066	negative regulation of apoptosis
GO:0043154	negative regulation of caspase activity
GO:0045963	negative regulation of dopamine metabolic process
GO:0051585	negative regulation of dopamine uptake
GO:0045920	negative regulation of exocytosis
GO:0035067	negative regulation of histone acetylation
GO:0031115	negative regulation of microtubule polymerization
GO:0032769	negative regulation of monooxygenase activity
GO:0043524	negative regulation of neuron apoptosis
GO:0051622	negative regulation of norepinephrine uptake
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0001933	negative regulation of protein amino acid phosphorylation
GO:0051612	negative regulation of serotonin uptake
GO:0070495	negative regulation of thrombin receptor signaling pathway
GO:0032410	negative regulation of transporter activity
GO:0006638	neutral lipid metabolic process
GO:0055114	oxidation reduction
GO:0006644	phospholipid metabolic process
GO:0045807	positive regulation of endocytosis
GO:0060732	positive regulation of inositol phosphate biosynthetic process
GO:0001956	positive regulation of neurotransmitter secretion
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0001921	positive regulation of receptor recycling
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0050806	positive regulation of synaptic transmission
GO:0031648	protein destabilization
GO:0031623	receptor internalization
GO:0050812	regulation of acyl-CoA biosynthetic process
GO:0014059	regulation of dopamine secretion
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0014048	regulation of glutamate secretion
GO:0040012	regulation of locomotion
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0043030	regulation of macrophage activation
GO:0043523	regulation of neuron apoptosis
GO:0048168	regulation of neuronal synaptic plasticity
GO:0046928	regulation of neurotransmitter secretion
GO:0010517	regulation of phospholipase activity
GO:0042493	response to drug
GO:0034341	response to interferon-gamma
GO:0070555	response to interleukin-1
GO:0010040	response to iron(II) ion
GO:0032496	response to lipopolysaccharide
GO:0032026	response to magnesium ion
GO:0050808	synapse organization
GO:0007268	synaptic transmission
GO:0001963	synaptic transmission, dopaminergic
GO:0048488	synaptic vesicle endocytosis
GO:0048489	synaptic vesicle transport

Cellular Component

GO:0015629	actin cytoskeleton
GO:0030424	axon
GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0030659	cytoplasmic vesicle membrane
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0043205	fibril
GO:0005794	Golgi apparatus
GO:0030426	growth cone
GO:0016234	inclusion body
GO:0043231	intracellular membrane-bounded organelle
GO:0005739	mitochondrion
GO:0043679	nerve terminal
GO:0005640	nuclear outer membrane
GO:0005634	nucleus
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane
GO:0031092	platelet alpha granule membrane
GO:0005840	ribosome
GO:0005791	rough endoplasmic reticulum
GO:0045202	synapse
GO:0008021	synaptic vesicle
GO:0043195	terminal button

Molecular Function

GO:0043014	alpha-tubulin binding
GO:0050544	arachidonic acid binding
GO:0048487	beta-tubulin binding
GO:0005509	calcium ion binding
GO:0043027	caspase inhibitor activity
GO:0005507	copper ion binding
GO:0045502	dynein binding
GO:0019899	enzyme binding
GO:0008198	ferrous iron binding
GO:0042393	histone binding
GO:0030544	Hsp70 protein binding
GO:0042802	identical protein binding
GO:0019894	kinesin binding
GO:0000287	magnesium ion binding
GO:0046872	metal ion binding
GO:0008017	microtubule binding
GO:0016491	oxidoreductase activity
GO:0043274	phospholipase binding
GO:0005543	phospholipid binding
GO:0051219	phosphoprotein binding
GO:0019904	protein domain specific binding
GO:0047485	protein N-terminus binding
GO:0048156	tau protein binding
GO:0008270	zinc ion binding

synuclein, alpha

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function