sphingosine kinase 1

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同義遺伝子名

sphingosine kinase 1, Sphk1, 1110006G24Rik

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:- 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:7.90
GeneChip 大脳:5.01 小脳:4.93 脳幹:- 脳梁:- 松果体:- 末梢神経:5.38 脊柱:5.09 網膜:4.95 目:5.13 動脈:- 静脈:6.63 リンパ節:5.04 末梢血:- 脾臓:5.92 胸腺:- 骨髄:9.05 脂肪:5.50 骨:8.25 皮膚:8.13
CAGE 大脳:0.81 小脳:- 脳幹:0.47 脳梁:- 松果体:- 末梢神経:- 脊柱:0.44 網膜:- 目:- 動脈:0.36 静脈:- リンパ節:0.23 末梢血:- 脾臓:2.80 胸腺:0.82 骨髄:- 脂肪:- 骨:2.53 皮膚:2.01
RNA-seq 大脳:1.61 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:37.20 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:-        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-
GeneChip 子宮:7.88 胎盤:7.15 前立腺:5.23 卵巣:6.45 精巣:5.30 心臓:5.13 骨格筋:5.16 食道:- 胃:5.10 腸:5.41 結腸:- 肝臓:5.51 肺:7.89 膀胱:6.26 腎臓:5.63 下垂体:4.83 甲状腺:- 副腎:4.53 膵臓:6.47 乳腺:5.37 唾液腺:5.13
CAGE 子宮:2.16 胎盤:3.15 前立腺:0.20 卵巣:1.31 精巣:0.45 心臓:- 骨格筋:- 食道:- 胃:1.07 腸:1.49 結腸:1.19     肝臓:0.64    肺:2.48 膀胱:1.20 腎臓:- 下垂体:0.29 甲状腺:- 副腎:0.47 膵臓:0.84 乳腺:0.93 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.21 食道:- 胃:- 腸:- 結腸:-     肝臓:0.65        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_025367
Gene ID 20698
Unigene ID Mm.209448
Probe set ID 1451596_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000061878

オーソログ対応遺伝子

ヒト[4]  NM_001142601, NM_001142602, NM_021972, NM_182965
ラット[1]  NM_133386, NM_001142602, NM_021972, NM_182965

染色体

-

遺伝子ファミリー (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

遺伝子オントロジー  (GO ID)

Biological Process

GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0001568  blood vessel development
GO:0007420  brain development
GO:0019722  calcium-mediated signaling
GO:0019371  cyclooxygenase pathway
GO:0006954  inflammatory response
GO:0046834  lipid phosphorylation
GO:0043066  negative regulation of apoptosis
GO:0016310  phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0030307  positive regulation of cell growth
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0048146  positive regulation of fibroblast proliferation
GO:0045931  positive regulation of mitotic cell cycle
GO:0010976  positive regulation of neuron projection development
GO:0001956  positive regulation of neurotransmitter secretion
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0031398  positive regulation of protein ubiquitination
GO:0045987  positive regulation of smooth muscle contraction
GO:0032651  regulation of interleukin-1 beta production
GO:0010803  regulation of tumor necrosis factor-mediated signaling pathway
GO:0006670  sphingosine metabolic process

Cellular Component

GO:0030424  axon
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0043005  neuron projection
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0008021  synaptic vesicle

Molecular Function

GO:0005524  ATP binding
GO:0005516  calmodulin binding
GO:0017050  D-erythro-sphingosine kinase activity
GO:0004143  diacylglycerol kinase activity
GO:0003677  DNA binding
GO:0016301  kinase activity
GO:0000287  magnesium ion binding
GO:0000166  nucleotide binding
GO:0051721  protein phosphatase 2A binding
GO:0008481  sphinganine kinase activity
GO:0016740  transferase activity