spleen tyrosine kinase

詳細情報を見る

同義遺伝子名

Spleen tyrosine kinase, spleen tyrosine kinase, Syk, Tyrosine-protein kinase SYK

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:6.90

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:95.50

脊柱:-

網膜:-

目:7.60

動脈:168.80

静脈:-

リンパ節:64.80

末梢血:115

脾臓:263.30

胸腺:148.20

骨髄:166.70

脂肪:-

骨:37.60

皮膚:31.70

GeneChip

大脳:5.41

小脳:5.36

脳幹:-

脳梁:-

松果体:-

末梢神経:5.13

脊柱:5.71

網膜:5.76

目:6.83

動脈:-

静脈:6.08

リンパ節:10.36

末梢血:-

脾臓:11.25

胸腺:-

骨髄:10.29

脂肪:7.15

骨:10.13

皮膚:6.09

CAGE

大脳:0.89

小脳:-

脳幹:0.94

脳梁:-

松果体:-

末梢神経:-

脊柱:1.23

網膜:-

目:-

動脈:2.98

静脈:-

リンパ節:5.07

末梢血:-

脾臓:4.70

胸腺:3.14

骨髄:-

脂肪:-

骨:4.46

皮膚:2.50

RNA-seq

大脳:1.05

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:14.80

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:35.20

肝臓:54.30

肺:50.20

膀胱:-

腎臓:24.20

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:26.10

唾液腺:-

GeneChip

子宮:6.97

胎盤:6.15

前立腺:5.90

卵巣:6.88

精巣:6.02

心臓:7.38

骨格筋:6.51

食道:-

胃:7.07

腸:8.21

結腸:-

肝臓:6.52

肺:7.81

膀胱:6.12

腎臓:5.65

下垂体:5.41

甲状腺:-

副腎:5.91

膵臓:6.16

乳腺:7.12

唾液腺:5.82

CAGE

子宮:2.10

胎盤:1.72

前立腺:1.35

卵巣:2.34

精巣:0.45

心臓:-

骨格筋:-

食道:-

胃:1.07

腸:1.96

結腸:2.37

肝臓:1.58

肺:3.72

膀胱:1.73

腎臓:-

下垂体:0.70

甲状腺:-

副腎:2.08

膵臓:2.66

乳腺:2.48

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.36

食道:-

胃:-

腸:-

結腸:-

肝臓:1.61

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_011518
Gene ID	20963
Unigene ID	Mm.375031
Probe set ID	1418261_at [Mouse430_2]
Ensembl ID	ENSMUSG00000021457

オーソログ対応遺伝子

ヒト[4]	NM_001135052, NM_001174167, NM_001174168, NM_003177
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR012234	Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0007257	activation of JUN kinase activity
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0050853	B cell receptor signaling pathway
GO:0043366	beta selection
GO:0048514	blood vessel morphogenesis
GO:0007166	cell surface receptor linked signal transduction
GO:0071226	cellular response to molecule of fungal origin
GO:0042742	defense response to bacterium
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007186	G-protein coupled receptor protein signaling pathway
GO:0045087	innate immune response
GO:0007229	integrin-mediated signaling pathway
GO:0002366	leukocyte activation during immune response
GO:0007159	leukocyte adhesion
GO:0019370	leukotriene biosynthetic process
GO:0001945	lymph vessel development
GO:0002281	macrophage activation during immune response
GO:0002283	neutrophil activation during immune response
GO:0030593	neutrophil chemotaxis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0016310	phosphorylation
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0045579	positive regulation of B cell differentiation
GO:0045780	positive regulation of bone resorption
GO:0050850	positive regulation of calcium-mediated signaling
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0050715	positive regulation of cytokine secretion
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045401	positive regulation of interleukin-3 biosynthetic process
GO:0043306	positive regulation of mast cell degranulation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0050776	regulation of immune response
GO:0043313	regulation of neutrophil degranulation
GO:0050764	regulation of phagocytosis
GO:0010543	regulation of platelet activation
GO:0032928	regulation of superoxide release
GO:0001820	serotonin secretion
GO:0002554	serotonin secretion by platelet

Cellular Component

GO:0019815	B cell receptor complex
GO:0005737	cytoplasm
GO:0031410	cytoplasmic vesicle
GO:0032009	early phagosome
GO:0016020	membrane
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0042101	T cell receptor complex

Molecular Function

GO:0005524	ATP binding
GO:0005178	integrin binding
GO:0016301	kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004713	protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

spleen tyrosine kinase

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function