transcription factor 7-like 2, T-cell specific, HMG-box

詳細情報を見る

同義遺伝子名

mTcf-4E, Transcription factor 7-like 2, mTcf-4B, Tcf7l2, TCF4E, Tcf-4, TCF4B, TCF-4, T-cell-specific transcription factor 4, mTCF-4, HMG box transcription factor 4

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:137.20 小脳:18.40 脳幹:444.90 脳梁:- 松果体:257.80 末梢神経:19.10 脊柱:- 網膜:32.10 目:38 動脈:337.60 静脈:- リンパ節:54 末梢血:301.90 脾臓:- 胸腺:128.40 骨髄:12.80 脂肪:425.40 骨:37.60 皮膚:23.80
GeneChip 大脳:5.50 小脳:5.01 脳幹:- 脳梁:- 松果体:- 末梢神経:5.03 脊柱:5.40 網膜:5.73 目:5.68 動脈:- 静脈:5.73 リンパ節:5.19 末梢血:- 脾臓:5.43 胸腺:- 骨髄:4.92 脂肪:5.55 骨:5.27 皮膚:5.52
CAGE 大脳:3.11 小脳:- 脳幹:4.46 脳梁:- 松果体:- 末梢神経:- 脊柱:3.16 網膜:- 目:- 動脈:4.94 静脈:- リンパ節:4.81 末梢血:- 脾臓:4.06 胸腺:3.18 骨髄:- 脂肪:- 骨:3.41 皮膚:5.18
RNA-seq 大脳:2.64 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:13.80 前立腺:30.90 卵巣:- 精巣:7.40 心臓:74.40 骨格筋:- 食道:- 胃:294.60 腸:- 結腸:105.70     肝臓:-        肺:100.40    膀胱:132.40 腎臓:72.50 下垂体:116.30 甲状腺:112.50 副腎:- 膵臓:187.60 乳腺:84.90 唾液腺:54
GeneChip 子宮:5.50 胎盤:5.82 前立腺:5.85 卵巣:5.74 精巣:5.38 心臓:5.86 骨格筋:5.58 食道:- 胃:6 腸:6.77 結腸:- 肝臓:6.02 肺:5.53 膀胱:5.44 腎臓:5.65 下垂体:5.20 甲状腺:- 副腎:5.97 膵臓:5.57 乳腺:6.48 唾液腺:6.29
CAGE 子宮:4.17 胎盤:4.23 前立腺:4.85 卵巣:4.53 精巣:3.31 心臓:- 骨格筋:- 食道:- 胃:4.42 腸:4.89 結腸:5.26     肝臓:4.35    肺:4.26 膀胱:4.45 腎臓:- 下垂体:3.71 甲状腺:- 副腎:3.84 膵臓:4.41 乳腺:5.99 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.12 食道:- 胃:- 腸:- 結腸:-     肝臓:2.81        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_001142923
Gene ID 21416
Unigene ID Mm.139815
Probe set ID 1425229_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000024985

オーソログ対応遺伝子

ヒト[36]  NM_001146274, NM_001146283, NM_001146284, NM_001146285, NM_001146286, NM_001198525, NM_001198526, NM_001198527, NM_001198528, NM_001198529, NM_001198531, NM_030756
ラット [0]  

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

遺伝子オントロジー  (GO ID)

Biological Process

GO:0001568  blood vessel development
GO:0030282  bone mineralization
GO:0007050  cell cycle arrest
GO:0008283  cell proliferation
GO:0048557  embryonic digestive tract morphogenesis
GO:0030538  embryonic genitalia morphogenesis
GO:0048619  embryonic hindgut morphogenesis
GO:0060325  face morphogenesis
GO:0045444  fat cell differentiation
GO:0042593  glucose homeostasis
GO:0043570  maintenance of DNA repeat elements
GO:0048625  myoblast cell fate commitment
GO:0030514  negative regulation of BMP signaling pathway
GO:0045599  negative regulation of fat cell differentiation
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0046621  negative regulation of organ growth
GO:0043433  negative regulation of transcription factor activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0090090  negative regulation of Wnt receptor signaling pathway through beta-catenin
GO:0021915  neural tube development
GO:0042475  odontogenesis of dentine-containing tooth
GO:0014003  oligodendrocyte development
GO:0021983  pituitary gland development
GO:0043065  positive regulation of apoptosis
GO:0050679  positive regulation of epithelial cell proliferation
GO:0010909  positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0032024  positive regulation of insulin secretion
GO:0032092  positive regulation of protein binding
GO:0046827  positive regulation of protein export from nucleus
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0032350  regulation of hormone metabolic process
GO:0031641  regulation of myelination
GO:0048713  regulation of oligodendrocyte differentiation
GO:0048641  regulation of skeletal muscle tissue development
GO:0048660  regulation of smooth muscle cell proliferation
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0006355  regulation of transcription, DNA-dependent
GO:0009749  response to glucose stimulus
GO:0032252  secretory granule localization
GO:0043588  skin development
GO:0035019  somatic stem cell maintenance
GO:0006351  transcription, DNA-dependent
GO:0016055  Wnt receptor signaling pathway
GO:0060070  Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0070369  beta-catenin-TCF7L2 complex
GO:0005829  cytosol
GO:0000790  nuclear chromatin
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0032993  protein-DNA complex
GO:0005667  transcription factor complex

Molecular Function

GO:0070016  armadillo repeat domain binding
GO:0008013  beta-catenin binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0045295  gamma-catenin binding
GO:0035257  nuclear hormone receptor binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding