endothelial-specific receptor tyrosine kinase

同義遺伝子名

Tie2, mTIE2, CD202b antigen, Angiopoietin-1 receptor precursor, p140 TEK, HYK, Hyk, Cd202b, Tunica interna endothelial cell kinase, Tek, Tie-2, Tyrosine-protein kinase receptor TIE-2, endothelial-specific receptor tyrosine kinase, Tyrosine-protein kinase receptor TEK, STK1

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

nodata

GeneChip

大脳:6.61

小脳:6.39

脳幹:-

脳梁:-

松果体:-

末梢神経:6.23

脊柱:6.65

網膜:5.51

目:6.34

動脈:-

静脈:9.22

リンパ節:7.13

末梢血:-

脾臓:6.62

胸腺:-

骨髄:6.55

脂肪:8.52

骨:7.38

皮膚:7.39

CAGE

大脳:2.36

小脳:-

脳幹:2.77

脳梁:-

松果体:-

末梢神経:-

脊柱:2.70

網膜:-

目:-

動脈:3.97

静脈:-

リンパ節:2.43

末梢血:-

脾臓:2.18

胸腺:1.35

骨髄:-

脂肪:-

骨:2.19

皮膚:2.82

RNA-seq

大脳:1.59

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

nodata

GeneChip

子宮:8.42

胎盤:7.87

前立腺:6.67

卵巣:8.15

精巣:5.44

心臓:9.22

骨格筋:8.21

食道:-

胃:6.77

腸:6.37

結腸:-

肝臓:7.88

肺:11.88

膀胱:7.75

腎臓:8.40

下垂体:6.88

甲状腺:-

副腎:9.72

膵臓:6.82

乳腺:7.85

唾液腺:5.67

CAGE

子宮:2.70

胎盤:3.19

前立腺:1.84

卵巣:2.83

精巣:0.45

心臓:-

骨格筋:-

食道:-

胃:1.91

腸:1.60

結腸:1.93

肝臓:3.04

肺:5.38

膀胱:3.02

腎臓:-

下垂体:2.66

甲状腺:-

副腎:3.97

膵臓:2.56

乳腺:2.76

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:2.47

食道:-

胃:-

腸:-

結腸:-

肝臓:2.41

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_013690
Gene ID	21687
Unigene ID	-
Probe set ID	1418788_at [Mouse430_2]
Ensembl ID	ENSMUSG00000006386

オーソログ対応遺伝子

ヒト[2]	NM_000459
ラット[1]	NM_001105737

染色体

遺伝子ファミリー (Interpro ID)

IPR000742	EGF-like, type 3
IPR003961	Fibronectin, type III
IPR008957	Fibronectin, type III-like fold
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0016337	cell-cell adhesion
GO:0007160	cell-matrix adhesion
GO:0001935	endothelial cell proliferation
GO:0007507	heart development
GO:0060347	heart trabecula formation
GO:0030097	hemopoiesis
GO:0016525	negative regulation of angiogenesis
GO:0043066	negative regulation of apoptosis
GO:0001569	patterning of blood vessels
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0016310	phosphorylation
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0010595	positive regulation of endothelial cell migration
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0051894	positive regulation of focal adhesion formation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0043552	positive regulation of phosphoinositide 3-kinase activity
GO:0014068	positive regulation of phosphoinositide 3-kinase cascade
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0010740	positive regulation of protein kinase cascade
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0051259	protein oligomerization
GO:0045765	regulation of angiogenesis
GO:0030334	regulation of cell migration
GO:0001936	regulation of endothelial cell proliferation
GO:0032878	regulation of establishment or maintenance of cell polarity
GO:0043627	response to estrogen stimulus
GO:0032526	response to retinoic acid
GO:0002040	sprouting angiogenesis
GO:0034446	substrate adhesion-dependent cell spreading
GO:0048014	Tie receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0001570	vasculogenesis

Cellular Component

GO:0005884	actin filament
GO:0016324	apical plasma membrane
GO:0009925	basal plasma membrane
GO:0016323	basolateral plasma membrane
GO:0030054	cell junction
GO:0009986	cell surface
GO:0005911	cell-cell junction
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005576	extracellular region
GO:0016021	integral to membrane
GO:0005887	integral to plasma membrane
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005902	microvillus
GO:0005886	plasma membrane
GO:0001725	stress fiber

Molecular Function

GO:0005524	ATP binding
GO:0019838	growth factor binding
GO:0016301	kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0004714	transmembrane receptor protein tyrosine kinase activity

endothelial-specific receptor tyrosine kinase

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function