toll-like receptor 4

詳細情報を見る

同義遺伝子名

Tlr4, lipopolysaccharide response, CD284 antigen, toll-like receptor 4, Toll-like receptor 4 precursor, Ly87, Rasl2-8, Lps, Ran/M1

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

EST 大脳:8.70 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:47.30 網膜:- 目:- 動脈:168.80 静脈:- リンパ節:10.80 末梢血:28.80 脾臓:79 胸腺:19.80 骨髄:- 脂肪:- 骨:- 皮膚:31.70
GeneChip 大脳:3.80 小脳:3.99 脳幹:- 脳梁:- 松果体:- 末梢神経:4.53 脊柱:3.74 網膜:3.93 目:6.02 動脈:- 静脈:5.56 リンパ節:6.67 末梢血:- 脾臓:6.17 胸腺:- 骨髄:6.86 脂肪:5.82 骨:6.71 皮膚:4.57
CAGE 大脳:1.34 小脳:- 脳幹:1.36 脳梁:- 松果体:- 末梢神経:- 脊柱:1.38 網膜:- 目:- 動脈:3.89 静脈:- リンパ節:4.13 末梢血:- 脾臓:3.04 胸腺:2.03 骨髄:- 脂肪:- 骨:3.25 皮膚:2.92
RNA-seq 大脳:0.93 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:18.60 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:27.20        肺:30.10    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:9.40 乳腺:6.50 唾液腺:-
GeneChip 子宮:6.86 胎盤:5.90 前立腺:5.97 卵巣:6.05 精巣:3.87 心臓:6.64 骨格筋:5.01 食道:- 胃:6.09 腸:5.73 結腸:- 肝臓:4.08 肺:6.33 膀胱:6.45 腎臓:4.61 下垂体:4.61 甲状腺:- 副腎:4.72 膵臓:4.62 乳腺:6.16 唾液腺:5.34
CAGE 子宮:3.90 胎盤:3.56 前立腺:2.81 卵巣:3.35 精巣:0.99 心臓:- 骨格筋:- 食道:- 胃:2.66 腸:1.29 結腸:1.68     肝臓:2.16    肺:3.56 膀胱:3.44 腎臓:- 下垂体:2.66 甲状腺:- 副腎:2.60 膵臓:2.03 乳腺:3.73 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.98 食道:- 胃:- 腸:- 結腸:-     肝臓:1.38        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

IDs

Refseq ID NM_021297
Gene ID 21898
Unigene ID Mm.380491
Probe set ID 1418162_at  [Mouse430_2]
Ensembl ID ENSMUSG00000039005

オーソログ対応遺伝子

ヒト[1]  NM_138554
ラット [0]  

染色体

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遺伝子ファミリー (Interpro ID)

Link to Pubmed  (Pubmed ID)

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遺伝子オントロジー  (GO ID)

Biological Process

GO:0002218  activation of innate immune response
GO:0000187  activation of MAPK activity
GO:0007250  activation of NF-kappaB-inducing kinase activity
GO:0002322  B cell proliferation during immune response
GO:0071222  cellular response to lipopolysaccharide
GO:0071223  cellular response to lipoteichoic acid
GO:0042742  defense response to bacterium
GO:0050829  defense response to Gram-negative bacterium
GO:0032497  detection of lipopolysaccharide
GO:0007252  I-kappaB phosphorylation
GO:0006955  immune response
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0002758  innate immune response-activating signal transduction
GO:0032609  interferon-gamma production
GO:0060729  intestinal epithelial structure maintenance
GO:0006691  leukotriene metabolic process
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0042116  macrophage activation
GO:0045576  mast cell activation
GO:0002282  microglial cell activation during immune response
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0032689  negative regulation of interferon-gamma production
GO:0032700  negative regulation of interleukin-17 production
GO:0032707  negative regulation of interleukin-23 production
GO:0032715  negative regulation of interleukin-6 production
GO:0032720  negative regulation of tumor necrosis factor production
GO:0052033  pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity
GO:0043065  positive regulation of apoptosis
GO:0030890  positive regulation of B cell proliferation
GO:0032722  positive regulation of chemokine production
GO:0043388  positive regulation of DNA binding
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0050729  positive regulation of inflammatory response
GO:0032727  positive regulation of interferon-alpha production
GO:0045359  positive regulation of interferon-beta biosynthetic process
GO:0032728  positive regulation of interferon-beta production
GO:0032729  positive regulation of interferon-gamma production
GO:0045362  positive regulation of interleukin-1 biosynthetic process
GO:0032732  positive regulation of interleukin-1 production
GO:0032733  positive regulation of interleukin-10 production
GO:0045084  positive regulation of interleukin-12 biosynthetic process
GO:0032735  positive regulation of interleukin-12 production
GO:0045368  positive regulation of interleukin-13 biosynthetic process
GO:0045410  positive regulation of interleukin-6 biosynthetic process
GO:0032755  positive regulation of interleukin-6 production
GO:0045416  positive regulation of interleukin-8 biosynthetic process
GO:0032757  positive regulation of interleukin-8 production
GO:0046330  positive regulation of JNK cascade
GO:0050671  positive regulation of lymphocyte proliferation
GO:0060907  positive regulation of macrophage cytokine production
GO:0045348  positive regulation of MHC class II biosynthetic process
GO:0042346  positive regulation of NF-kappaB import into nucleus
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0045429  positive regulation of nitric oxide biosynthetic process
GO:0051770  positive regulation of nitric-oxide synthase biosynthetic process
GO:0070430  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050731  positive regulation of peptidyl-tyrosine phosphorylation
GO:0010572  positive regulation of platelet activation
GO:0032874  positive regulation of stress-activated MAPK cascade
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042535  positive regulation of tumor necrosis factor biosynthetic process
GO:0032760  positive regulation of tumor necrosis factor production
GO:0002537  production of nitric oxide during acute inflammatory response
GO:0050707  regulation of cytokine secretion
GO:0050727  regulation of inflammatory response
GO:0051930  regulation of sensory perception of pain
GO:0009617  response to bacterium
GO:0045471  response to ethanol
GO:0070542  response to fatty acid
GO:0032496  response to lipopolysaccharide
GO:0006979  response to oxidative stress
GO:0007165  signal transduction
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005737  cytoplasm
GO:0009897  external side of plasma membrane
GO:0016021  integral to membrane
GO:0005887  integral to plasma membrane
GO:0046696  lipopolysaccharide receptor complex
GO:0016020  membrane
GO:0045121  membrane raft
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0001530  lipopolysaccharide binding
GO:0001875  lipopolysaccharide receptor activity
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0004872  receptor activity
GO:0004888  transmembrane receptor activity