Werner syndrome homolog (human)

 詳細情報を見る

同義遺伝子名

Wrn, AI846146, Werner syndrome ATP-dependent helicase homolog, Werner syndrome homolog (human)

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:12.20 小脳:- 脳幹:31.80 脳梁:- 松果体:- 末梢神経:57.30 脊柱:- 網膜:- 目:38 動脈:- 静脈:- リンパ節:64.80 末梢血:28.80 脾臓:39.50 胸腺:79 骨髄:- 脂肪:- 骨:- 皮膚:-
GeneChip 大脳:5.38 小脳:5.09 脳幹:- 脳梁:- 松果体:- 末梢神経:5.68 脊柱:5.43 網膜:4.92 目:5.31 動脈:- 静脈:6.51 リンパ節:7.16 末梢血:- 脾臓:6.93 胸腺:- 骨髄:8.61 脂肪:6.07 骨:8.10 皮膚:5.92
CAGE 大脳:2.22 小脳:- 脳幹:2.31 脳梁:- 松果体:- 末梢神経:- 脊柱:2.42 網膜:- 目:- 動脈:3.29 静脈:- リンパ節:4.22 末梢血:- 脾臓:4.07 胸腺:3.90 骨髄:- 脂肪:- 骨:4.21 皮膚:3.15
RNA-seq 大脳:1.00 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:27.60 前立腺:92.60 卵巣:23 精巣:36.90 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:9.10        肺:40.20    膀胱:- 腎臓:- 下垂体:51.70 甲状腺:- 副腎:- 膵臓:37.50 乳腺:19.60 唾液腺:-
GeneChip 子宮:5.98 胎盤:6.62 前立腺:5.92 卵巣:6.07 精巣:7.82 心臓:5.12 骨格筋:4.81 食道:- 胃:5.89 腸:6.45 結腸:- 肝臓:5.83 肺:6.05 膀胱:6.02 腎臓:5.99 下垂体:5.98 甲状腺:- 副腎:5.89 膵臓:6.21 乳腺:5.92 唾液腺:5.40
CAGE 子宮:2.95 胎盤:2.94 前立腺:3.02 卵巣:3.24 精巣:2.51 心臓:- 骨格筋:- 食道:- 胃:1.75 腸:2.19 結腸:3.10     肝臓:2.90    肺:3.44 膀胱:3.08 腎臓:- 下垂体:3.00 甲状腺:- 副腎:3.05 膵臓:2.90 乳腺:2.70 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:1.32 食道:- 胃:- 腸:- 結腸:-     肝臓:1.70        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_011721
Gene ID 22427
Unigene ID Mm.228805
Probe set ID 1450163_a_at  [Mouse430_2]
Ensembl ID ENSMUSG00000031583

オーソログ対応遺伝子

ヒト[1]  NM_000553
ラット[1]  NM_000553

染色体

8A4  [34,344,856  -  34,495,999]

遺伝子ファミリー (Interpro ID)

IPR002562  3'-5' exonuclease
IPR014001  DEAD-like helicase, N-terminal
IPR004589  DNA helicase, ATP-dependent, RecQ type
IPR014021  Helicase, superfamily 1/2, ATP-binding domain
IPR012337  Polynucleotidyl transferase, ribonuclease H fold

Link to Pubmed  (Pubmed ID)

8602509
8889548
9143515
9618508
9681877
9789047
10349636
10757074
10757812
10782115
10806190
10871373
10922068
11042159
11076861
11087671
11217851
11280729
11301316
11420665
11756244
11863428
12242664
12466851
12477932
12707040
12803543
12944467
14595844
14610273
15235603
15367665
15642393
15743673
16141072
16141073
16195394
16264192
16330174
16769258
16785251
17229737
18295300
18588880
18799693
19896421
20708636
21123451
21267068
21464516
22301954
22753033

遺伝子オントロジー  (GO ID)

Biological Process

GO:0006200  ATP catabolic process
GO:0006284  base-excision repair
GO:0007569  cell aging
GO:0044237  cellular metabolic process
GO:0071480  cellular response to gamma radiation
GO:0009267  cellular response to starvation
GO:0032508  DNA duplex unwinding
GO:0006259  DNA metabolic process
GO:0006310  DNA recombination
GO:0006281  DNA repair
GO:0006260  DNA replication
GO:0000731  DNA synthesis during DNA repair
GO:0006302  double-strand break repair
GO:0008152  metabolic process
GO:0010259  multicellular organismal aging
GO:0006139  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0032066  nucleolus to nucleoplasm transport
GO:0051345  positive regulation of hydrolase activity
GO:0042981  regulation of apoptosis
GO:0040009  regulation of growth rate
GO:0031297  replication fork processing
GO:0001302  replicative cell aging
GO:0006974  response to DNA damage stimulus
GO:0006979  response to oxidative stress
GO:0010225  response to UV-C
GO:0000723  telomere maintenance

Cellular Component

GO:0005813  centrosome
GO:0005622  intracellular
GO:0032389  MutLalpha complex
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0043138  3'-5' DNA helicase activity
GO:0008408  3'-5' exonuclease activity
GO:0005524  ATP binding
GO:0043140  ATP-dependent 3'-5' DNA helicase activity
GO:0004003  ATP-dependent DNA helicase activity
GO:0008026  ATP-dependent helicase activity
GO:0016887  ATPase activity
GO:0000405  bubble DNA binding
GO:0003824  catalytic activity
GO:0003677  DNA binding
GO:0003678  DNA helicase activity
GO:0004527  exonuclease activity
GO:0009378  four-way junction helicase activity
GO:0051880  G-quadruplex DNA binding
GO:0004386  helicase activity
GO:0016787  hydrolase activity
GO:0000287  magnesium ion binding
GO:0030145  manganese ion binding
GO:0046872  metal ion binding
GO:0004518  nuclease activity
GO:0003676  nucleic acid binding
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0032403  protein complex binding
GO:0042803  protein homodimerization activity
GO:0000403  Y-form DNA binding