mitogen-activated protein kinase kinase 1

同義遺伝子名

Mek1, MAP kinase kinase 1, MAPK/ERK kinase 1, Prkmk1, ERK activator kinase 1, MAPKK1, MEK1, mitogen activated protein kinase kinase 1, MAPKK 1, MEKK1, Map2k1

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:194.50

小脳:-

脳幹:254.20

脳梁:-

松果体:-

末梢神経:210.20

脊柱:-

網膜:128.60

目:121.60

動脈:-

静脈:-

リンパ節:172.80

末梢血:43.10

脾臓:144.80

胸腺:98.80

骨髄:38.50

脂肪:-

骨:62.60

皮膚:87.10

GeneChip

大脳:11.34

小脳:10.23

脳幹:-

脳梁:-

松果体:-

末梢神経:10.32

脊柱:9.89

網膜:9.55

目:9

動脈:-

静脈:9.29

リンパ節:9.82

末梢血:-

脾臓:9.93

胸腺:-

骨髄:9.25

脂肪:9.18

骨:9.23

皮膚:8.43

CAGE

大脳:4.71

小脳:-

脳幹:4.53

脳梁:-

松果体:-

末梢神経:-

脊柱:4.33

網膜:-

目:-

動脈:3.69

静脈:-

リンパ節:4.09

末梢血:-

脾臓:3.73

胸腺:3.41

骨髄:-

脂肪:-

骨:3.94

皮膚:3.54

RNA-seq

大脳:38.10

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:174.50

胎盤:193.30

前立腺:30.90

卵巣:252.80

精巣:36.90

心臓:260.40

骨格筋:71

食道:-

胃:32.70

腸:-

結腸:105.70

肝臓:-

肺:100.40

膀胱:132.40

腎臓:64.50

下垂体:25.80

甲状腺:-

副腎:-

膵臓:46.90

乳腺:81.60

唾液腺:-

GeneChip

子宮:9.27

胎盤:10.60

前立腺:9.01

卵巣:9.33

精巣:6.40

心臓:9.02

骨格筋:9.77

食道:-

胃:10.51

腸:10.35

結腸:-

肝臓:9.32

肺:9.37

膀胱:9.63

腎臓:8.94

下垂体:9.85

甲状腺:-

副腎:9.11

膵臓:8.77

乳腺:9.21

唾液腺:8.43

CAGE

子宮:4.05

胎盤:4.40

前立腺:3.58

卵巣:3.72

精巣:2.05

心臓:-

骨格筋:-

食道:-

胃:4.28

腸:4.41

結腸:4.38

肝臓:3.97

肺:3.81

膀胱:3.82

腎臓:-

下垂体:4.01

甲状腺:-

副腎:3.87

膵臓:2.66

乳腺:3.68

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:13.98

食道:-

胃:-

腸:-

結腸:-

肝臓:6.76

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_008927
Gene ID	26395
Unigene ID	Mm.248907
Probe set ID	1416351_at [Mouse430_2]
Ensembl ID	ENSMUSG00000004936

オーソログ対応遺伝子

ヒト[1]	NM_002755
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

遺伝子オントロジー (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0007050	cell cycle arrest
GO:0048870	cell motility
GO:0008283	cell proliferation
GO:0048313	Golgi inheritance
GO:0030216	keratinocyte differentiation
GO:0060711	labyrinthine layer development
GO:0000165	MAPKKK cascade
GO:0032402	melanosome transport
GO:0007067	mitosis
GO:0008285	negative regulation of cell proliferation
GO:0034111	negative regulation of homotypic cell-cell adhesion
GO:0030182	neuron differentiation
GO:0048812	neuron projection morphogenesis
GO:0016310	phosphorylation
GO:0060674	placenta blood vessel development
GO:0045597	positive regulation of cell differentiation
GO:0030335	positive regulation of cell migration
GO:0032320	positive regulation of Ras GTPase activity
GO:0046579	positive regulation of Ras protein signal transduction
GO:0032968	positive regulation of RNA elongation from RNA polymerase II promoter
GO:0006468	protein amino acid phosphorylation
GO:0051291	protein heterooligomerization
GO:0090170	regulation of Golgi inheritance
GO:0032872	regulation of stress-activated MAPK cascade
GO:0003056	regulation of vascular smooth muscle contraction
GO:0048678	response to axon injury
GO:0051384	response to glucocorticoid stimulus
GO:0006979	response to oxidative stress
GO:0047496	vesicle transport along microtubule

Cellular Component

GO:0033267	axon part
GO:0005938	cell cortex
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0030425	dendrite
GO:0032839	dendrite cytoplasm
GO:0005769	early endosome
GO:0005925	focal adhesion
GO:0005794	Golgi apparatus
GO:0005770	late endosome
GO:0005874	microtubule
GO:0005739	mitochondrion
GO:0005634	nucleus
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0004708	MAP kinase kinase activity
GO:0031435	mitogen-activated protein kinase kinase kinase binding
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0017016	Ras GTPase binding
GO:0004728	receptor signaling protein tyrosine phosphatase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

mitogen-activated protein kinase kinase 1

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function