mitogen-activated protein kinase kinase kinase 1

同義遺伝子名

MAPK/ERK kinase kinase 1, Mekk, MAPKKK1, Mekk1, MEK kinase 1, Mitogen-activated protein kinase kinase kinase 1, mitogen activated protein kinase kinase kinase 1, Map3k1, MEKK1, MEKK 1

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:60.80

小脳:92.10

脳幹:63.60

脳梁:-

松果体:-

末梢神経:57.30

脊柱:-

網膜:-

目:91.20

動脈:-

静脈:-

リンパ節:32.40

末梢血:43.10

脾臓:-

胸腺:108.70

骨髄:51.30

脂肪:-

骨:125.20

皮膚:87.10

GeneChip

大脳:5.09

小脳:5.17

脳幹:-

脳梁:-

松果体:-

末梢神経:6.40

脊柱:4.89

網膜:7.51

目:7.81

動脈:-

静脈:6.12

リンパ節:8.17

末梢血:-

脾臓:8.28

胸腺:-

骨髄:7.40

脂肪:6.73

骨:7.50

皮膚:7.89

CAGE

大脳:2.10

小脳:-

脳幹:1.90

脳梁:-

松果体:-

末梢神経:-

脊柱:1.55

網膜:-

目:-

動脈:2.74

静脈:-

リンパ節:3.44

末梢血:-

脾臓:3.73

胸腺:3.45

骨髄:-

脂肪:-

骨:3.64

皮膚:3.81

RNA-seq

大脳:0.97

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:87.20

胎盤:69

前立腺:-

卵巣:68.90

精巣:88.70

心臓:55.80

骨格筋:106.50

食道:-

胃:32.70

腸:-

結腸:35.20

肝臓:27.20

肺:70.30

膀胱:132.40

腎臓:8.10

下垂体:51.70

甲状腺:-

副腎:-

膵臓:225.20

乳腺:124.10

唾液腺:-

GeneChip

子宮:6.85

胎盤:7.01

前立腺:6.75

卵巣:7.23

精巣:5.01

心臓:6.35

骨格筋:5.57

食道:-

胃:6.65

腸:6.80

結腸:-

肝臓:6.03

肺:6.56

膀胱:6.80

腎臓:6.60

下垂体:5.71

甲状腺:-

副腎:7.19

膵臓:6.54

乳腺:7.27

唾液腺:8.69

CAGE

子宮:3.20

胎盤:2.88

前立腺:2.51

卵巣:3.17

精巣:2.19

心臓:-

骨格筋:-

食道:-

胃:1.75

腸:3.04

結腸:2.92

肝臓:2.06

肺:3.17

膀胱:2.92

腎臓:-

下垂体:2.22

甲状腺:-

副腎:3.35

膵臓:3.27

乳腺:3.42

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.49

食道:-

胃:-

腸:-

結腸:-

肝臓:1.32

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_011945
Gene ID	26401
Unigene ID	Mm.159185
Probe set ID	1424850_at [Mouse430_2]
Ensembl ID	ENSMUSG00000021754

オーソログ対応遺伝子

ヒト[1]	NM_005921
ラット[2]	NM_053887

染色体

遺伝子ファミリー (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain
IPR007527	Zinc finger, SWIM-type

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

GO:0007256	activation of JNKK activity
GO:0007257	activation of JUN kinase activity
GO:0000186	activation of MAPKK activity
GO:0008637	apoptotic mitochondrial changes
GO:0043010	camera-type eye development
GO:0007254	JNK cascade
GO:0000165	MAPKKK cascade
GO:0032232	negative regulation of actin filament bundle formation
GO:0018105	peptidyl-serine phosphorylation
GO:0016310	phosphorylation
GO:0030838	positive regulation of actin filament polymerization
GO:0043065	positive regulation of apoptosis
GO:0043507	positive regulation of JUN kinase activity
GO:0043406	positive regulation of MAP kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050434	positive regulation of viral transcription
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0051259	protein oligomerization
GO:0000209	protein polyubiquitination
GO:0042787	protein ubiquitination during ubiquitin-dependent protein catabolic process
GO:0030334	regulation of cell migration
GO:0006970	response to osmotic stress
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0042060	wound healing

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane

Molecular Function

GO:0005524	ATP binding
GO:0042802	identical protein binding
GO:0008432	JUN kinase binding
GO:0008545	JUN kinase kinase activity
GO:0004706	JUN kinase kinase kinase activity
GO:0016301	kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0046872	metal ion binding
GO:0051019	mitogen-activated protein kinase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0004674	protein serine/threonine kinase activity
GO:0046625	sphingolipid binding
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0004842	ubiquitin-protein ligase activity
GO:0008270	zinc ion binding

mitogen-activated protein kinase kinase kinase 1

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function