mitogen-activated protein kinase kinase kinase 10

 詳細情報を見る

同義遺伝子名

BC046514, Map3k10, serine/threonine kinase, BC028668, Mlk2, mitogen activated protein kinase kinase kinase 10, MKN28 derived nonreceptor_type, MKN28 kinase, mixed lineage kinase 2

発現データ

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類 の発現パターンを使用しています。

組織40分類別データ

脳 血 結
EST 大脳:34.70 小脳:55.30 脳幹:63.60 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:15.20 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:79 骨髄:- 脂肪:- 骨:12.50 皮膚:-
GeneChip nodata
CAGE 大脳:3.84 小脳:- 脳幹:3.76 脳梁:- 松果体:- 末梢神経:- 脊柱:3.52 網膜:- 目:- 動脈:2.24 静脈:- リンパ節:0.57 末梢血:- 脾臓:1.78 胸腺:1.80 骨髄:- 脂肪:- 骨:2.59 皮膚:2.31
RNA-seq 大脳:17.59 小脳:- 脳幹:- 脳梁:- 松果体:- 末梢神経:- 脊柱:- 網膜:- 目:- 動脈:- 静脈:- リンパ節:- 末梢血:- 脾臓:- 胸腺:- 骨髄:- 脂肪:- 骨:- 皮膚:-
殖 筋 消 肝 肺 腎 泌
EST 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:- 食道:- 胃:- 腸:- 結腸:-     肝臓:9.10        肺:20.10    膀胱:198.50 腎臓:8.10 下垂体:25.80 甲状腺:- 副腎:- 膵臓:- 乳腺:13.10 唾液腺:-
GeneChip nodata
CAGE 子宮:2.03 胎盤:2.07 前立腺:2.35 卵巣:2.42 精巣:3.92 心臓:- 骨格筋:- 食道:- 胃:1.91 腸:1.75 結腸:2.16     肝臓:2.23    肺:2.03 膀胱:2.64 腎臓:- 下垂体:2.75 甲状腺:- 副腎:2.73 膵臓:3.04 乳腺:2.51 唾液腺:-
RNA-seq 子宮:- 胎盤:- 前立腺:- 卵巣:- 精巣:- 心臓:- 骨格筋:6.18 食道:- 胃:- 腸:- 結腸:-     肝臓:1.93        肺:-    膀胱:- 腎臓:- 下垂体:- 甲状腺:- 副腎:- 膵臓:- 乳腺:- 唾液腺:-

詳細情報

IDs

Refseq ID NM_001081292
Gene ID 269881
Unigene ID Mm.389883
Probe set ID -
Ensembl ID ENSMUSG00000040390

オーソログ対応遺伝子

ヒト[1]  NM_002446
ラット [0]  

染色体

7A3  [28,441,394  -  28,459,617]

遺伝子ファミリー (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8889548
9890743
10349636
11042159
11076861
11217851
12466851
12477932
14610273
15062575
15489334
16141072
16141073
18287559
18414056
18855897
19801649
21267068
21979919
23954791

遺伝子オントロジー  (GO ID)

Biological Process

GO:0008219  cell death
GO:0043433  negative regulation of transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0016310  phosphorylation
GO:0043065  positive regulation of apoptosis
GO:0046330  positive regulation of JNK cascade
GO:0043507  positive regulation of JUN kinase activity
GO:0006468  protein amino acid phosphorylation
GO:0007224  smoothened signaling pathway

Cellular Component

GO:0005737  cytoplasm

Molecular Function

GO:0005524  ATP binding
GO:0043425  bHLH transcription factor binding
GO:0016301  kinase activity
GO:0004709  MAP kinase kinase kinase activity
GO:0000166  nucleotide binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0003714  transcription corepressor activity
GO:0016740  transferase activity
GO:0016772  transferase activity, transferring phosphorus-containing groups