leucine-rich repeat kinase 2

詳細情報を見る

同義遺伝子名

AW561911, Gm927, D630001M17Rik, 9330188B09Rik, leucine-rich repeat kinase 2, Lrrk2, cI-46, 4921513O20Rik

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:-

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

GeneChip

大脳:7.15

小脳:7.16

脳幹:-

脳梁:-

松果体:-

末梢神経:7.47

脊柱:6.08

網膜:4.80

目:5.68

動脈:-

静脈:6.05

リンパ節:8.15

末梢血:-

脾臓:8.50

胸腺:-

骨髄:7.92

脂肪:5.66

骨:7.80

皮膚:4.95

CAGE

大脳:3.02

小脳:-

脳幹:2.48

脳梁:-

松果体:-

末梢神経:-

脊柱:2.57

網膜:-

目:-

動脈:2.41

静脈:-

リンパ節:4.87

末梢血:-

脾臓:3.73

胸腺:1.90

骨髄:-

脂肪:-

骨:3.57

皮膚:2.40

RNA-seq

大脳:4.13

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:-

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

GeneChip

子宮:4.93

胎盤:4.70

前立腺:4.78

卵巣:5.80

精巣:6.38

心臓:6.42

骨格筋:5.67

食道:-

胃:4.92

腸:5.09

結腸:-

肝臓:4.62

肺:8.87

膀胱:6.27

腎臓:9.22

下垂体:5.79

甲状腺:-

副腎:6.24

膵臓:5.27

乳腺:5.52

唾液腺:4.59

CAGE

子宮:1.98

胎盤:1.49

前立腺:1.35

卵巣:2.88

精巣:1.89

心臓:-

骨格筋:-

食道:-

胃:0.67

腸:1.29

結腸:1.40

肝臓:1.38

肺:4.44

膀胱:2.99

腎臓:-

下垂体:2.50

甲状腺:-

副腎:2.74

膵臓:1.61

乳腺:1.73

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.32

食道:-

胃:-

腸:-

結腸:-

肝臓:1.15

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_025730
Gene ID	66725
Unigene ID	Mm.375584
Probe set ID	1431394_a_at [Mouse430_2]
Ensembl ID	ENSMUSG00000036273

オーソログ対応遺伝子

ヒト[1]	NM_198578
ラット [0]

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

GO:0000187	activation of MAPK activity
GO:0000186	activation of MAPKK activity
GO:0006914	autophagy
GO:0008340	determination of adult lifespan
GO:0006184	GTP catabolic process
GO:0048312	intracellular distribution of mitochondria
GO:0000165	MAPKKK cascade
GO:0034260	negative regulation of GTPase activity
GO:0007406	negative regulation of neuroblast proliferation
GO:0014043	negative regulation of neuron maturation
GO:0007528	neuromuscular junction development
GO:0070997	neuron death
GO:0021772	olfactory bulb development
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0016310	phosphorylation
GO:0010508	positive regulation of autophagy
GO:0010942	positive regulation of cell death
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0043068	positive regulation of programmed cell death
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0031398	positive regulation of protein ubiquitination
GO:0046777	protein amino acid autophosphorylation
GO:0006468	protein amino acid phosphorylation
GO:0040012	regulation of locomotion
GO:0042391	regulation of membrane potential
GO:0006979	response to oxidative stress
GO:0007264	small GTPase mediated signal transduction
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb

Cellular Component

GO:0030424	axon
GO:0043025	cell soma
GO:0005737	cytoplasm
GO:0030425	dendrite
GO:0032839	dendrite cytoplasm
GO:0032473	external side of mitochondrial outer membrane
GO:0005622	intracellular
GO:0043231	intracellular membrane-bounded organelle
GO:0016020	membrane
GO:0045121	membrane raft
GO:0005739	mitochondrion
GO:0043005	neuron projection
GO:0005886	plasma membrane
GO:0045202	synapse
GO:0008021	synaptic vesicle
GO:0005802	trans-Golgi network

Molecular Function

GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0034211	GTP-dependent protein kinase activity
GO:0005096	GTPase activator activity
GO:0003924	GTPase activity
GO:0042802	identical protein binding
GO:0016301	kinase activity
GO:0004708	MAP kinase kinase activity
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0017048	Rho GTPase binding
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0015631	tubulin binding

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR013753	Ras
IPR001806	Ras GTPase
IPR003579	Ras small GTPase, Rab type
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR005225	Small GTP-binding protein
IPR020851	Small GTPase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

leucine-rich repeat kinase 2

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function