sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)

同義遺伝子名

Sir2, AA673258, Sirt1, Sir2alpha, Sir2l1, Sir2a, mSIR2a, SIR2L1, NAD-dependent deacetylase sirtuin-1, SIR2-like protein 1, SIR2alpha

正常組織・臓器 40分類
正常組織 (発生期含む)・初代培養細胞（FANTOM5 CAGE）

発現マップ on BodyParts3D

相対発現量を、人体 3D 画像にマップしたものです。Genechip 組織40分類の発現パターンを使用しています。

組織40分類別データ

脳

血

結

EST

大脳:12.20

小脳:55.30

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:45.60

動脈:-

静脈:-

リンパ節:-

末梢血:71.90

脾臓:65.80

胸腺:69.20

骨髄:-

脂肪:212.70

骨:-

皮膚:63.30

GeneChip

大脳:6.96

小脳:7.63

脳幹:-

脳梁:-

松果体:-

末梢神経:7.04

脊柱:6.06

網膜:8.69

目:8.07

動脈:-

静脈:7.48

リンパ節:8.48

末梢血:-

脾臓:8.12

胸腺:-

骨髄:8.99

脂肪:7.17

骨:8.71

皮膚:7.85

CAGE

大脳:2.76

小脳:-

脳幹:2.31

脳梁:-

松果体:-

末梢神経:-

脊柱:2.40

網膜:-

目:-

動脈:3.06

静脈:-

リンパ節:3.19

末梢血:-

脾臓:3.17

胸腺:3.18

骨髄:-

脂肪:-

骨:3.71

皮膚:3.12

RNA-seq

大脳:1.56

小脳:-

脳幹:-

脳梁:-

松果体:-

末梢神経:-

脊柱:-

網膜:-

目:-

動脈:-

静脈:-

リンパ節:-

末梢血:-

脾臓:-

胸腺:-

骨髄:-

脂肪:-

骨:-

皮膚:-

殖

筋

消

肝

肺

腎

泌

EST

子宮:-

胎盤:55.20

前立腺:61.80

卵巣:46

精巣:29.60

心臓:18.60

骨格筋:-

食道:-

胃:-

腸:-

結腸:-

肝臓:-

肺:40.20

膀胱:-

腎臓:24.20

下垂体:12.90

甲状腺:-

副腎:-

膵臓:-

乳腺:26.10

唾液腺:-

GeneChip

子宮:7.60

胎盤:7.75

前立腺:7.88

卵巣:8.04

精巣:7.98

心臓:7.29

骨格筋:7.17

食道:-

胃:7.11

腸:7.76

結腸:-

肝臓:7.10

肺:7.87

膀胱:7.65

腎臓:7.32

下垂体:7.42

甲状腺:-

副腎:8.31

膵臓:6.30

乳腺:7.43

唾液腺:6.97

CAGE

子宮:2.65

胎盤:2.67

前立腺:2.74

卵巣:2.98

精巣:3.77

心臓:-

骨格筋:-

食道:-

胃:2.60

腸:2.79

結腸:2.90

肝臓:2.70

肺:3.17

膀胱:2.81

腎臓:-

下垂体:2.58

甲状腺:-

副腎:2.84

膵臓:2.75

乳腺:2.54

唾液腺:-

RNA-seq

子宮:-

胎盤:-

前立腺:-

卵巣:-

精巣:-

心臓:-

骨格筋:1.28

食道:-

胃:-

腸:-

結腸:-

肝臓:2.67

肺:-

膀胱:-

腎臓:-

下垂体:-

甲状腺:-

副腎:-

膵臓:-

乳腺:-

唾液腺:-

IDs

Refseq ID	NM_001159590
Gene ID	93759
Unigene ID	Mm.351459
Probe set ID	1418640_at [Mouse430_2]
Ensembl ID	ENSMUSG00000020063

オーソログ対応遺伝子

ヒト[2]	NM_001142498, NM_012238
ラット[2]	NM_001142498, NM_012238

染色体

10B4 [62,781,753 - 62,844,452]

近くの遺伝子を探す
- -5kb から +5kb の範囲
- -10kb から +10kb の範囲

遺伝子ファミリー (Interpro ID)

IPR003000

NAD-dependent histone deacetylase, silent information regulator Sir2

遺伝子オントロジー (GO ID)

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptosis
GO:0030154	cell differentiation
GO:0001678	cellular glucose homeostasis
GO:0070301	cellular response to hydrogen peroxide
GO:0071456	cellular response to hypoxia
GO:0071479	cellular response to ionizing radiation
GO:0009267	cellular response to starvation
GO:0071356	cellular response to tumor necrosis factor
GO:0042632	cholesterol homeostasis
GO:0000183	chromatin silencing at rDNA
GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0008630	DNA damage response, signal transduction resulting in induction of apoptosis
GO:0000731	DNA synthesis during DNA repair
GO:0006343	establishment of chromatin silencing
GO:0055089	fatty acid homeostasis
GO:0016575	histone deacetylation
GO:0070932	histone H3 deacetylation
GO:0006344	maintenance of chromatin silencing
GO:0007275	multicellular organismal development
GO:0007517	muscle organ development
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0043066	negative regulation of apoptosis
GO:0030308	negative regulation of cell growth
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045599	negative regulation of fat cell differentiation
GO:0051097	negative regulation of helicase activity
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042326	negative regulation of phosphorylation
GO:0031393	negative regulation of prostaglandin biosynthetic process
GO:0051898	negative regulation of protein kinase B signaling cascade
GO:0032007	negative regulation of TOR signaling pathway
GO:0043433	negative regulation of transcription factor activity
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0001542	ovulation from ovarian follicle
GO:0018394	peptidyl-lysine acetylation
GO:0034983	peptidyl-lysine deacetylation
GO:0002821	positive regulation of adaptive immune response
GO:0043065	positive regulation of apoptosis
GO:0043280	positive regulation of caspase activity
GO:0008284	positive regulation of cell proliferation
GO:0010875	positive regulation of cholesterol efflux
GO:0031937	positive regulation of chromatin silencing
GO:0045739	positive regulation of DNA repair
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0016239	positive regulation of macroautophagy
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0001934	positive regulation of protein amino acid phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
GO:0006476	protein amino acid deacetylation
GO:0031648	protein destabilization
GO:0016567	protein ubiquitination
GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0070857	regulation of bile acid biosynthetic process
GO:0042127	regulation of cell proliferation
GO:0032071	regulation of endodeoxyribonuclease activity
GO:0010906	regulation of glucose metabolic process
GO:0007346	regulation of mitotic cell cycle
GO:0033158	regulation of protein import into nucleus, translocation
GO:0080134	regulation of response to stress
GO:0034391	regulation of smooth muscle cell apoptosis
GO:0006355	regulation of transcription, DNA-dependent
GO:0006974	response to DNA damage stimulus
GO:0032868	response to insulin stimulus
GO:0006979	response to oxidative stress
GO:0006364	rRNA processing
GO:0000012	single strand break repair
GO:0007283	spermatogenesis
GO:0006351	transcription, DNA-dependent
GO:0006642	triglyceride mobilization
GO:0050872	white fat cell differentiation

Cellular Component

GO:0000785	chromatin
GO:0005677	chromatin silencing complex
GO:0005737	cytoplasm
GO:0035098	ESC/E(Z) complex
GO:0005739	mitochondrion
GO:0000790	nuclear chromatin
GO:0005635	nuclear envelope
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin
GO:0005637	nuclear inner membrane
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0016605	PML body
GO:0033553	rDNA heterochromatin

Molecular Function

GO:0043425	bHLH transcription factor binding
GO:0019213	deacetylase activity
GO:0019899	enzyme binding
GO:0042393	histone binding
GO:0004407	histone deacetylase activity
GO:0043398	HLH domain binding
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0051019	mitogen-activated protein kinase binding
GO:0070403	NAD binding
GO:0017136	NAD-dependent histone deacetylase activity
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0034979	NAD-dependent protein deacetylase activity
GO:0002039	p53 binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0033558	protein deacetylase activity
GO:0019904	protein domain specific binding
GO:0003714	transcription corepressor activity

sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)

同義遺伝子名

発現データ

発現マップ on BodyParts3D

組織40分類別データ

詳細情報

IDs

オーソログ対応遺伝子

染色体

遺伝子ファミリー (Interpro ID)

Link to Pubmed (Pubmed ID)

遺伝子オントロジー (GO ID)

Biological Process

Cellular Component

Molecular Function