branched chain ketoacid dehydrogenase kinase

 jump to detail

Synonym

BCKDK, BCKDHKIN, branched chain ketoacid dehydrogenase kinase, Branched-chain alpha-ketoacid dehydrogenase kinase, BCKD-kinase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:71.10 cerebellum:75.60 brain stem:- corpus callosum/glia:116.60 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:117.50 artery/aorta:60 vein:66.60 lymphnode:50.60 peripheral blood:182.20 spleen:56.70 thymus:77.30 bone marrow:- adipose:121 bone:102.40 skin:33.60
GeneChip cerebrum:6.13 cerebellum:5.82 brain stem:6.16 corpus callosum/glia:5.91 pineal gland:- peripheral nerve:6.33 spine:6.03 retina:- eye:- artery/aorta:6.63 vein:6.50 lymphnode:6.43 peripheral blood:- spleen:6.11 thymus:5.74 bone marrow:6.35 adipose:6.67 bone:- skin:6.85
CAGE cerebrum:4.03 cerebellum:- brain stem:3.64 corpus callosum/glia:3.55 pineal gland:3.79 peripheral nerve:- spine:3.94 retina:- eye:- artery/aorta:4.44 vein:3.88 lymphnode:4.12 peripheral blood:- spleen:3.78 thymus:3.18 bone marrow:- adipose:3.46 bone:- skin:-
RNA-seq cerebrum:1.17 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.16 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.18 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:102 prostate:33.80 ovary:149.10 testis:212 heart:102.20 muscle:160.70 esophagus:- stomach:85 intestine:194.40 colon:25.40     liver/hepato:95        lung:53.80    bladder:251.20 kidney:83.20 pituitary:- thyroid/parathyroid:- adrenal gland:253.90 pancreas:17.80 breast:65.10 salivary:656.80
GeneChip uterus:6.29 placenta:5.90 prostate:6.45 ovary:6.39 testis:6.17 heart:6.81 muscle:7.29 esophagus:6.71 stomach:6.47 intestine:6.74 colon:6.45 liver/hepato:7.16 lung:6.45 bladder:- kidney:6.88 pituitary:5.88 thyroid/parathyroid:6.57 adrenal gland:6.80 pancreas:7.18 breast:6.86 salivary:7.79
CAGE uterus:3.60 placenta:3.52 prostate:3.57 ovary:3.68 testis:3.75 heart:4.62 muscle:5.04 esophagus:3.68 stomach:- intestine:3.72 colon:3.86     liver/hepato:4.86    lung:4.02 bladder:3.71 kidney:4.04 pituitary:3.37 thyroid/parathyroid:3.49 adrenal gland:- pancreas:5.06 breast:4.18 salivary:4.75
RNA-seq uterus:- placenta:- prostate:2.02 ovary:2.53 testis:1.28 heart:2.31 muscle:1.76 esophagus:- stomach:- intestine:- colon:1.26     liver/hepato:1.58        lung:0.79    bladder:- kidney:1.38 pituitary:- thyroid/parathyroid:2.13 adrenal gland:2.59 pancreas:- breast:1.83 salivary:-

Gene Information

IDs

Refseq ID NM_001122957
Gene ID 10295
Unigene ID Hs.513520
Probe set ID 202030_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000103507
GTEx ID ENSG00000103507

Orthologous Gene

Mouse[1]  NM_009739
Rat [0]  

Chromosomal Region

16p11.2  [31,117,428  -  31,123,888]

Gene Family (Interpro ID)

IPR003594  ATPase-like, ATP-binding domain
IPR004358  Signal transduction histidine kinase-related protein, C-terminal

Link to Pubmed  (Pubmed ID)

1377677
1889817
2403034
8889548
11839747
12023963
12477932
15489334
15604093
17000644
17353931
18985028
19913121
20628086
20811636
20877624
21832049
21890473
21988832
24654937
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0009083  branched chain family amino acid catabolic process
GO:0009063  cellular amino acid catabolic process
GO:0016310  phosphorylation

Cellular Component

GO:0005947  mitochondrial alpha-ketoglutarate dehydrogenase complex
GO:0005739  mitochondrion

Molecular Function

GO:0005524  ATP binding
GO:0016301  kinase activity
GO:0005515  protein binding
GO:0004674  protein serine/threonine kinase activity
GO:0047323  [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity