RhoA/RAC/CDC42 exchange factor

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Synonym

p63RhoGEF, GEFT, RAC/CDC42 exchange factor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:24.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip nodata
CAGE cerebrum:4.45 cerebellum:- brain stem:3.08 corpus callosum/glia:2.75 pineal gland:3.29 peripheral nerve:- spine:3.49 retina:- eye:- artery/aorta:4.55 vein:2.97 lymphnode:2.07 peripheral blood:- spleen:2.60 thymus:0.28 bone marrow:- adipose:2.59 bone:- skin:-
RNA-seq cerebrum:1.74 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.17 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.38 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:173.20 placenta:7.30 prostate:22.50 ovary:37.30 testis:13 heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:25.40     liver/hepato:-        lung:14.70    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:- salivary:-
GeneChip nodata
CAGE uterus:4.03 placenta:1.76 prostate:4.05 ovary:3.33 testis:2.85 heart:3.13 muscle:2.35 esophagus:3.78 stomach:- intestine:2.69 colon:3.83     liver/hepato:1.29    lung:2.63 bladder:4.41 kidney:2.08 pituitary:3.07 thyroid/parathyroid:1.87 adrenal gland:- pancreas:2.26 breast:3.73 salivary:2.39
RNA-seq uterus:- placenta:- prostate:1.70 ovary:1.73 testis:1.71 heart:0.49 muscle:0.09 esophagus:- stomach:- intestine:- colon:2.22     liver/hepato:0.00        lung:0.53    bladder:- kidney:0.25 pituitary:- thyroid/parathyroid:0.45 adrenal gland:1.63 pancreas:- breast:1.14 salivary:-

Gene Information

IDs

Refseq ID NM_182947
Gene ID 115557
Unigene ID Hs.61581
Probe set ID -
Ensembl ID ENSG00000240771
GTEx ID ENSG00000240771

Orthologous Gene

Mouse[4]  NM_001166413, NM_028027
Rat[4]  NM_001166413, NM_028027

Chromosomal Region

12q13.3  [58,003,963  -  58,017,959]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology

Link to Pubmed  (Pubmed ID)

11861769
12477932
12547822
15069594
15322108
15632174
16314529
16496360
18096806
18851832
18936096
20739613
21663592
21832057
21885830
22147804
23380069
23884432

Gene Ontology  (GO ID)

Biological Process

GO:0035023  regulation of Rho protein signal transduction

Cellular Component

GO:0005829  cytosol
GO:0030016  myofibril
GO:0005886  plasma membrane
GO:0030017  sarcomere

Molecular Function

GO:0005543  phospholipid binding
GO:0005089  Rho guanyl-nucleotide exchange factor activity