hypermethylated in cancer 2

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Synonym

KIAA1020, Hypermethylated in cancer 2 protein, Hic-2, ZBTB30, Hic-3, HRG22, hypermethylated in cancer 2, HIC1-related gene on chromosome 22, Zinc finger and BTB domain-containing protein 30, HIC2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:13 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:70.50 artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:18.90 thymus:64.40 bone marrow:- adipose:40.30 bone:- skin:-
GeneChip cerebrum:5.61 cerebellum:5.57 brain stem:5.56 corpus callosum/glia:5.40 pineal gland:- peripheral nerve:5.25 spine:5.27 retina:- eye:- artery/aorta:5.51 vein:5.90 lymphnode:5.62 peripheral blood:- spleen:5.40 thymus:5.55 bone marrow:5.66 adipose:5.52 bone:- skin:5.44
CAGE cerebrum:0.54 cerebellum:- brain stem:0 corpus callosum/glia:0 pineal gland:1.23 peripheral nerve:- spine:0.80 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0.06 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:0.44 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.98 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.94 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:32.80 prostate:- ovary:- testis:38.90 heart:89.40 muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:-        lung:4.90    bladder:- kidney:41.60 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:35.60 breast:18.60 salivary:-
GeneChip uterus:5.40 placenta:6.03 prostate:5.11 ovary:5.46 testis:5.67 heart:5.42 muscle:5.49 esophagus:5.62 stomach:5.57 intestine:5.50 colon:5.66 liver/hepato:5.55 lung:5.47 bladder:- kidney:5.60 pituitary:5.92 thyroid/parathyroid:5.64 adrenal gland:5.41 pancreas:5.62 breast:5.28 salivary:5.39
CAGE uterus:0.04 placenta:0 prostate:0 ovary:0 testis:0.07 heart:0 muscle:1.05 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0.08 pituitary:1.02 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.50 ovary:1.46 testis:2.40 heart:0.35 muscle:0.27 esophagus:- stomach:- intestine:- colon:0.59     liver/hepato:0.41        lung:0.64    bladder:- kidney:0.80 pituitary:- thyroid/parathyroid:0.71 adrenal gland:0.94 pancreas:- breast:0.60 salivary:-

Gene Information

IDs

Refseq ID NM_015094
Gene ID 23119
Unigene ID Hs.632767
Probe set ID 212965_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000169635
GTEx ID ENSG00000169635

Orthologous Gene

Mouse[2]  NM_178922
Rat[1]  NM_001105862

Chromosomal Region

22q11.21  [21,771,693  -  21,805,752]

Gene Family (Interpro ID)

IPR011333  BTB/POZ fold
IPR000210  BTB/POZ-like
IPR015880  Zinc finger, C2H2-like
IPR007087  Zinc finger, C2H2-type

Link to Pubmed  (Pubmed ID)

8889548
10470851
10591208
11554746
12052894
12168954
12477932
12944466
14702039
15146197
15461802
15489334
16169070
18029348
19838193
20139978
21832049
22990118

Gene Ontology  (GO ID)

Biological Process

GO:0045892  negative regulation of transcription, DNA-dependent
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005925  focal adhesion
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0003677  DNA binding
GO:0046872  metal ion binding
GO:0008022  protein C-terminus binding