SLIT-ROBO Rho GTPase activating protein 2

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Synonym

FNBP2, srGAP2, formin binding protein 2, KIAA0456, SLIT-ROBO Rho GTPase activating protein 2, srGAP3, SRGAP2, Formin-binding protein 2, SLIT-ROBO Rho GTPase-activating protein 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:105.50 cerebellum:340 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:122.70 spine:- retina:118.60 eye:70.50 artery/aorta:- vein:133.30 lymphnode:121.30 peripheral blood:18.20 spleen:56.70 thymus:77.30 bone marrow:39.40 adipose:40.30 bone:51.20 skin:33.60
GeneChip cerebrum:5.95 cerebellum:8.58 brain stem:6.37 corpus callosum/glia:6.23 pineal gland:- peripheral nerve:5.79 spine:5.90 retina:- eye:- artery/aorta:5.01 vein:4.99 lymphnode:5.36 peripheral blood:- spleen:6.08 thymus:5.43 bone marrow:5.25 adipose:5.28 bone:- skin:5.98
CAGE nodata
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:51 prostate:11.30 ovary:- testis:8.70 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:59.40     liver/hepato:52.80        lung:44    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:- breast:27.90 salivary:-
GeneChip uterus:5.32 placenta:6.06 prostate:4.80 ovary:5.78 testis:4.79 heart:4.94 muscle:4.73 esophagus:5.18 stomach:4.93 intestine:4.69 colon:4.75 liver/hepato:4.82 lung:5.66 bladder:- kidney:5.23 pituitary:4.77 thyroid/parathyroid:4.63 adrenal gland:5.92 pancreas:4.75 breast:5.28 salivary:4.47
CAGE nodata
RNA-seq uterus:- placenta:- prostate:0.01 ovary:2.14 testis:0.02 heart:0.13 muscle:0.13 esophagus:- stomach:- intestine:- colon:0.77     liver/hepato:1.19        lung:0.00    bladder:- kidney:0.72 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.75 pancreas:- breast:0.75 salivary:-

Gene Information

IDs

Refseq ID NM_015326
Gene ID 23380
Unigene ID Hs.497575
Probe set ID 213329_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000163486
GTEx ID ENSG00000163486

Orthologous Gene

Mouse[1]  NM_001081011
Rat [0]  

Chromosomal Region

1q32.1  [206,516,198  -  206,637,783]

Gene Family (Interpro ID)

IPR008936  Rho GTPase activation protein
IPR000198  RhoGAP

Link to Pubmed  (Pubmed ID)

8268792
9455484
11672528
12477932
12736724
14702039
15046868
15252450
15324660
16318909
17043677
17979178
19041431
19807924
19913121
20379614
20602751
20628086
20810653
21139048
21148482
21906983
21963094
22106086
22261722
22467852
22559943
22559944
22797925
23031429
23782070
23892896
24255178
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0051014  actin filament severing
GO:0007411  axon guidance
GO:0008283  cell proliferation
GO:0021816  extension of a leading process involved in cell locomotion in cerebral cortex radial glia guided migration
GO:0046847  filopodium assembly
GO:0003363  lamellipodium assembly involved in ameboidal cell migration
GO:0060548  negative regulation of cell death
GO:0048812  neuron projection morphogenesis
GO:0032855  positive regulation of Rac GTPase activity
GO:0051056  regulation of small GTPase mediated signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0034446  substrate adhesion-dependent cell spreading

Cellular Component

GO:0030054  cell junction
GO:0005829  cytosol
GO:0030027  lamellipodium
GO:0005634  nucleus
GO:0045335  phagocytic vesicle
GO:0005886  plasma membrane
GO:0014069  postsynaptic density
GO:0045211  postsynaptic membrane

Molecular Function

GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0030675  Rac GTPase activator activity
GO:0048365  Rac GTPase binding