ribosomal protein S6 kinase, 90kDa, polypeptide 6

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Synonym

RPS6KA6, Ribosomal S6 kinase 4, S6K-alpha 6, 90 kDa ribosomal protein S6 kinase 6, ribosomal protein S6 kinase, 90kDa, polypeptide 6, RSK4, p90-RSK 6, Ribosomal protein S6 kinase alpha-6, pp90RSK4, RSK-4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:3.74 cerebellum:3.77 brain stem:3.83 corpus callosum/glia:3.66 pineal gland:- peripheral nerve:3.82 spine:3.72 retina:- eye:- artery/aorta:3.95 vein:3.93 lymphnode:3.59 peripheral blood:- spleen:3.66 thymus:3.73 bone marrow:3.89 adipose:3.77 bone:- skin:4
CAGE cerebrum:0.91 cerebellum:- brain stem:0.51 corpus callosum/glia:0.43 pineal gland:1.72 peripheral nerve:- spine:0.32 retina:- eye:- artery/aorta:0.47 vein:0.18 lymphnode:0.12 peripheral blood:- spleen:0.17 thymus:0.28 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:1.13 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.43 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.22 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:- prostate:- ovary:- testis:17.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:3.76 placenta:3.80 prostate:3.74 ovary:3.88 testis:3.73 heart:3.72 muscle:3.96 esophagus:3.84 stomach:3.56 intestine:3.72 colon:3.84 liver/hepato:3.58 lung:3.57 bladder:- kidney:3.78 pituitary:4.11 thyroid/parathyroid:3.92 adrenal gland:3.77 pancreas:3.77 breast:3.66 salivary:3.60
CAGE uterus:0.66 placenta:0.16 prostate:0.66 ovary:0.68 testis:0.47 heart:0.20 muscle:0.05 esophagus:0.18 stomach:- intestine:0.66 colon:0.79     liver/hepato:0.14    lung:0.18 bladder:0.26 kidney:0.98 pituitary:1.55 thyroid/parathyroid:1.50 adrenal gland:- pancreas:0.94 breast:0 salivary:0.62
RNA-seq uterus:- placenta:- prostate:1.16 ovary:1.28 testis:1.37 heart:0.21 muscle:0.11 esophagus:- stomach:- intestine:- colon:1.12     liver/hepato:0.27        lung:0.57    bladder:- kidney:2.34 pituitary:- thyroid/parathyroid:2.32 adrenal gland:0.40 pancreas:- breast:0.33 salivary:-

Gene Information

IDs

Refseq ID NM_014496
Gene ID 27330
Unigene ID Hs.368153
Probe set ID 220738_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000072133
GTEx ID ENSG00000072133

Orthologous Gene

Mouse[1]  NM_025949
Rat [0]  

Chromosomal Region

Xq21.1  [83,318,984  -  83,442,933]

Gene Family (Interpro ID)

IPR000961  AGC-kinase, C-terminal
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

10644430
11160957
12477932
12832467
14702039
15042092
15632195
15772651
16169070
16865262
17314274
17709345
18029348
18628456
19584160
19679225
21239520
21372219
21384559
21832049
21875487
21890473
21900206
21963094
21987572
22020623
22297070
22939624
22939629
23635776
23942078
24250222
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0007417  central nervous system development
GO:0006978  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0045992  negative regulation of embryonic development
GO:0070373  negative regulation of ERK1 and ERK2 cascade
GO:0007243  protein kinase cascade
GO:0007165  signal transduction
GO:0007268  synaptic transmission

Cellular Component

GO:0005829  cytosol
GO:0005654  nucleoplasm

Molecular Function

GO:0005524  ATP binding
GO:0000287  magnesium ion binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity