protein arginine methyltransferase 2

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Synonym

HRMT1L1, HMT1, MGC111373, PRMT2, protein arginine methyltransferase 2, Protein arginine N-methyltransferase 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:220.40 cerebellum:88.20 brain stem:- corpus callosum/glia:145.80 pineal gland:296.70 peripheral nerve:153.40 spine:112.30 retina:- eye:241 artery/aorta:359.70 vein:199.90 lymphnode:111.20 peripheral blood:182.20 spleen:56.70 thymus:64.40 bone marrow:98.40 adipose:40.30 bone:166.30 skin:129.60
GeneChip cerebrum:7.63 cerebellum:7.01 brain stem:8.10 corpus callosum/glia:7.85 pineal gland:- peripheral nerve:7.70 spine:8.17 retina:- eye:- artery/aorta:7.34 vein:6.71 lymphnode:7.05 peripheral blood:- spleen:7.17 thymus:7.15 bone marrow:6.99 adipose:7.01 bone:- skin:6.85
CAGE cerebrum:4.70 cerebellum:- brain stem:4.89 corpus callosum/glia:4.84 pineal gland:4.76 peripheral nerve:- spine:5.63 retina:- eye:- artery/aorta:4.88 vein:4.10 lymphnode:3.99 peripheral blood:- spleen:4.09 thymus:3.73 bone marrow:- adipose:3.87 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.28 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:118.50 placenta:123.90 prostate:157.70 ovary:111.80 testis:21.60 heart:357.60 muscle:20.10 esophagus:- stomach:63.70 intestine:129.60 colon:59.40     liver/hepato:42.20        lung:171.10    bladder:251.20 kidney:156 pituitary:- thyroid/parathyroid:163.70 adrenal gland:50.80 pancreas:151.10 breast:223 salivary:-
GeneChip uterus:7.33 placenta:7.06 prostate:7.44 ovary:7.64 testis:6.48 heart:6.55 muscle:6.10 esophagus:6.73 stomach:6.88 intestine:6.65 colon:6.92 liver/hepato:5.96 lung:7.03 bladder:- kidney:6.91 pituitary:6.69 thyroid/parathyroid:7.02 adrenal gland:6.52 pancreas:6.25 breast:7.19 salivary:6.77
CAGE uterus:4.37 placenta:4.02 prostate:4.32 ovary:4.09 testis:3.59 heart:4.07 muscle:3.26 esophagus:4.04 stomach:- intestine:3.89 colon:3.91     liver/hepato:3.08    lung:4.21 bladder:4.00 kidney:3.99 pituitary:4.31 thyroid/parathyroid:3.72 adrenal gland:- pancreas:3.42 breast:4.63 salivary:3.93
RNA-seq uterus:- placenta:- prostate:2.19 ovary:3.30 testis:1.01 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.75        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.00 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_001535
Gene ID 3275
Unigene ID Hs.154163
Probe set ID 202098_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000160310
GTEx ID ENSG00000160310

Orthologous Gene

Mouse[4]  NM_001077638, NM_133182
Rat[1]  NM_001025144, NM_133182

Chromosomal Region

21q22.3  [48,055,079  -  48,085,036]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8125298
8619474
8889548
9110174
9196002
9545638
10830953
11513728
12039952
12477932
14667819
14702039
15146197
15489334
16189514
16344560
16368877
16616919
16648481
17587566
19101556
19161160
19405910
21820040
21851090
21963094
21988832
22093364
22179613
23455924

Gene Ontology  (GO ID)

Biological Process

GO:0048588  developmental cell growth
GO:0034969  histone arginine methylation
GO:0016571  histone methylation
GO:0032088  negative regulation of NF-kappaB transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0035246  peptidyl-arginine N-methylation
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006479  protein amino acid methylation
GO:0060765  regulation of androgen receptor signaling pathway
GO:0007165  signal transduction

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005634  nucleus
GO:0035189  Rb-E2F complex

Molecular Function

GO:0050681  androgen receptor binding
GO:0030331  estrogen receptor binding
GO:0042054  histone methyltransferase activity
GO:0008469  histone-arginine N-methyltransferase activity
GO:0042975  peroxisome proliferator activated receptor binding
GO:0033142  progesterone receptor binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0016274  protein-arginine N-methyltransferase activity
GO:0042974  retinoic acid receptor binding
GO:0004871  signal transducer activity
GO:0046966  thyroid hormone receptor binding
GO:0003713  transcription coactivator activity